PLX647

ChemicalBook > CAS DataBase List > PLX647

Product Name: PLX647
CAS No.: 873786-09-5
Chemical Name: PLX647
Synonyms: PLC647;PLX647;CS-1696;PLX 647;PLX-647;[5-[(1H-Pyrrolo[2,3-b]pyridin-3-yl)methyl]pyridin-2-yl](4-trifluoromethylbenzyl)amine;5-(1H-Pyrrolo[2,3-b]pyridin-3-ylmethyl)-N-[[4-(trifluoromethyl)phenyl]methyl]-2-pyridinamine;2-Pyridinamine, 5-(1H-pyrrolo[2,3-b]pyridin-3-ylmethyl)-N-[[4-(trifluoromethyl)phenyl]methyl]-
CBNumber: CB72667277
Molecular Formula: C21H17F3N4
Formula Weight: 382.38
MOL File: 873786-09-5.mol

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PLX647 Property

Density: 1.358±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: soluble20mg/mL, clear
form: powder
pka: 13.73±0.40(Predicted)
color: white to beige

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 36/37/39
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 18012
Product name: PLX647
Purity: ≥95%
Packaging: 5mg
Price: $97
Updated: 2024/03/01

Cayman Chemical

Product number: 18012
Product name: PLX647
Purity: ≥95%
Packaging: 10mg
Price: $184
Updated: 2024/03/01

Cayman Chemical

Product number: 18012
Product name: PLX647
Purity: ≥95%
Packaging: 25mg
Price: $433
Updated: 2024/03/01

Cayman Chemical

Product number: 18012
Product name: PLX647
Purity: ≥95%
Packaging: 50mg
Price: $768
Updated: 2024/03/01

TRC

Product number: P635003
Product name: PLX647
Packaging: 10mg
Price: $100
Updated: 2021/12/16

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PLX647 Chemical Properties,Usage,Production

Description

PLX647 is a dual inhibitor of the receptor tyrosine kinases FMS and KIT (IC₅₀s = 28 and 16 nM, respectively). It is selective for FMS and KIT but does inhibit FLT3 and KDR (IC₅₀s = 91 and 130 nM, respectively) in a panel of 400 kinases at a concentration of 1 μM. PLX647 inhibits proliferation of Ba/F3 cells expressing constitutively active FMS or KIT (IC₅₀s = 92 and 180 nM, respectively) as well as ligand-dependent growth of M-NFS-60 and M-07e cells that express endogenous FMS and KIT, respectively (IC₅₀s = 380 and 230 nM, respectively). It has no effect on HEK293T or HepG2 cells that lack FMS and KIT (IC₅₀ = >50 μM) or Ba/F3 cells overexpressing KDR (IC₅₀ = >5 μM). PLX647 also inhibits differentiation of human osteoclast precursor cells (IC₅₀ = 170 nM). In vivo, PLX647 (40 mg/kg) reduces TNF-α and IL-6 release in a rat model of LPS-induced cytokine release. It reduces mast cell degranulation in a mouse model of passive cutaneous anaphylaxis (PCA) and inhibits bone destruction and delays disease progression in a mouse model of collagen-induced arthritis (CIA). PLX647 also reverses bone osteolysis and allodynia in a syngeneic rat model of cancer-induced bone pain.

Uses

PLX647 is a novel tyrosine kinase (TK) inhibitor, which selectively targets c-Kit and c-Fms.

References

[1]. zhang c, ibrahim pn, zhang j, et al. design and pharmacology of a highly specific dual fms and kit kinase inhibitor. proc natl acad sci u s a, 2013, 110(14): 5689-5694.

PLX647 Preparation Products And Raw materials

Raw materials

Preparation Products

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873786-09-5, PLX647Related Search:

PLX-4720 PLX7904

PLX647

PLC647

5-(1H-Pyrrolo[2,3-b]pyridin-3-ylmethyl)-N-[[4-(trifluoromethyl)phenyl]methyl]-2-pyridinamine

2-Pyridinamine, 5-(1H-pyrrolo[2,3-b]pyridin-3-ylmethyl)-N-[[4-(trifluoromethyl)phenyl]methyl]-

PLX 647;PLX-647

CS-1696

[5-[(1H-Pyrrolo[2,3-b]pyridin-3-yl)methyl]pyridin-2-yl](4-trifluoromethylbenzyl)amine

873786-09-5

C21H17F3N4

Inhibitors