BVT 2733

ChemicalBook > CAS DataBase List > BVT 2733

Product Name: BVT 2733
CAS No.: 376640-41-4
Chemical Name: BVT 2733
Synonyms: BVT2733, >98%;BVT 2733(BVT.2733);BVT.2733 >=98% (HPLC);3-chloro-2-methyl-N-(4-(2-(4-methylpiperazin-1-yl)-2-oxoethyl)thiazol-2-yl)benzenesulfonamide;3-chloro-2-methyl-N-[4-[2-(4-methyl-1-piperazinyl)-2-oxoethyl]-2-thiazolyl]-benzenesulfonamide;BENZENESULFONAMIDE, 3-CHLORO-2-METHYL-N-[4-[2-(4-METHYL-1-PIPERAZINYL)-2-OXOETHYL]-2-THIAZOLYL]-;3-CHLORO-2-METHYL-N-[4-[2-(4-METHYLPIPERAZIN-1-YL)-2-OXOETHYL]-1,3-THIAZOL-2-YL]BENZENESULFONAMIDE;HFD,CIA,BVT-2733,J774.1,arthritis,macrophage,collagen,inhibit,BVT2733,BVT 2733,disease,adipocyte,Inhibitor,obesity
CBNumber: CB72667358
Molecular Formula: C17H21ClN4O3S2
Formula Weight: 428.96
MOL File: 376640-41-4.mol

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BVT 2733 Property

Boiling point:: 636.9±65.0 °C(Predicted)
Density: 1.427±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: ≥42.9 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
form: solid
pka: 6.36±0.10(Predicted)
color: Off-white to pink

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Safety

HS Code: 2935909099

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H302Harmful if swallowed

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1205
Product name: BVT.2733
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $118
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML1205
Product name: BVT.2733
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $370
Updated: 2024/03/01

Cayman Chemical

Product number: 22203
Product name: BVT 2733
Purity: ≥98%
Packaging: 5mg
Price: $90
Updated: 2024/03/01

Cayman Chemical

Product number: 22203
Product name: BVT 2733
Purity: ≥98%
Packaging: 10mg
Price: $171
Updated: 2024/03/01

Cayman Chemical

Product number: 22203
Product name: BVT 2733
Purity: ≥98%
Packaging: 25mg
Price: $400
Updated: 2024/03/01

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BVT 2733 Chemical Properties,Usage,Production

Uses

BVT 2733 is a selective inhibitor of 11β-hydroxysteroid dehydrogenase type 1.

Biological Activity

ki: 1 μm using 11-dehydrocorticosterone as substratebvt 2733 is a novel, small molecule, non-steroidal, and selective inhibitor of 11beta-hydroxysteroid dehydrogenase type 1 (11β-hsd1).11β-hsd1 has been reported to alter glucocorticoid hormone action in target tissues for insulin action and is suggested to play a key role in glucose homeostasis.

in vitro

bvt 2733 was identified as a novel type 1 selective inhibitor of murine 11β-hsd1 (ki 1 μmol/l), which did not inhibit mouse 11β-hsd type 2 at a concentration as high as 200 μmol/l (corresponding to a ki >33 μmol/l). therefore, the selectivity of bvt 2733 for the 11β-hsd type 1 enzyme over the type 2 enzyme was estimated to be at least 30-fold based on the ki values [1].

in vivo

in mice, bvt 2733 treatment could lower hepatic pepck and glucose-6-phosphatase mrna, serum insulin and blood glucose concentrations compared with vehicle treated mice. in contrast, hepatic 11beta-hydroxysteroid dehydrogenase type 1 mrna, liver function marker enzyme expression including alanine aminotransferase, aspartate aminotransferase and alkaline phosphatases, body weight as well as daily food intake were not changed by the treatment of bvt 2733 [1].

References

[1] alberts p,engblom l,edling n,forsgren m,klingstrm g,larsson c,rnquist-nii y,ohman b,abrahmsén l. selective inhibition of 11beta-hydroxysteroid dehydrogenase type 1 decreases blood glucose concentrations in hyperglycaemic mice. diabetologia.2002 nov;45(11):1528-32.

BVT 2733 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from BVT 2733 manufacturers

Career Henan Chemical Co

Product: 3-chloro-2-methyl-N-(4-(2-(4-methylpiperazin-1-yl)-2-oxoethyl)thiazol-2-yl)benzenesulfonamide 376640-41-4
Price: US $1.00/KG
Min. Order: 1KG
Purity: 95%~99%
Supply Ability: per week 100kg
Release date: 2019-09-05

376640-41-4, BVT 2733Related Search:

3-chloro-2-methyl-N-(4-(2-(4-methylpiperazin-1-yl)-2-oxoethyl)thiazol-2-yl)benzenesulfonamide

BVT 2733(BVT.2733)

BENZENESULFONAMIDE, 3-CHLORO-2-METHYL-N-[4-[2-(4-METHYL-1-PIPERAZINYL)-2-OXOETHYL]-2-THIAZOLYL]-

3-CHLORO-2-METHYL-N-[4-[2-(4-METHYLPIPERAZIN-1-YL)-2-OXOETHYL]-1,3-THIAZOL-2-YL]BENZENESULFONAMIDE

BVT2733, >98%

BVT.2733 >=98% (HPLC)

HFD,CIA,BVT-2733,J774.1,arthritis,macrophage,collagen,inhibit,BVT2733,BVT 2733,disease,adipocyte,Inhibitor,obesity

3-chloro-2-methyl-N-[4-[2-(4-methyl-1-piperazinyl)-2-oxoethyl]-2-thiazolyl]-benzenesulfonamide

376640-41-4

C17H21ClN4O3S2

Inhibitors