ChemicalBook > CAS DataBase List > kobe-2602

kobe-2602

Product Name
kobe-2602
CAS No.
454453-49-7
Chemical Name
kobe-2602
Synonyms
CS-1280;Kos2602;kobe2602;kobe 2602;kobe-2602;kobe2602, >96%;Kobe2602 ，S6527;Kobe 2602, >=98%;KOBE 2602; KOBE-2602;Kobe2602, 10 mM in DMSO
CBNumber
CB72667510
Molecular Formula
C14H9F4N5O4S
Formula Weight
419.31
MOL File
454453-49-7.mol
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kobe-2602 Property

Boiling point:
450.8±55.0 °C(Predicted)
Density 
1.691±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
insoluble in H2O; ≥17 mg/mL in DMSO; ≥17.53 mg/mL in EtOH with ultrasonic
form 
solid
pka
9.35±0.70(Predicted)
color 
Light yellow to brown
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
16262
Product name
Kobe 2602
Purity
≥98%
Packaging
10mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
16262
Product name
Kobe 2602
Purity
≥98%
Packaging
50mg
Price
$93
Updated
2024/03/01
Cayman Chemical
Product number
16262
Product name
Kobe 2602
Purity
≥98%
Packaging
100mg
Price
$153
Updated
2024/03/01
Cayman Chemical
Product number
16262
Product name
Kobe 2602
Purity
≥98%
Packaging
500mg
Price
$533
Updated
2024/03/01
TRC
Product number
D480435
Product name
2-[2,6-Dinitro-4-(trifluoromethyl)phenyl]-N-(4-fluorophenyl)hydrazinecarbothioamide
Packaging
1g
Price
$1320
Updated
2021/12/16
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kobe-2602 Chemical Properties,Usage,Production

Uses

2-[2,6-Dinitro-4-(trifluoromethyl)phenyl]-N-(4-fluorophenyl)hydrazinecarbothioamide is used in the preparation of pyrazolidine or pyrazole compounds which exhibit mild antimicrobial effects against various strains of bacteria.

Uses

Kobe 2602 is used in the preparation of pyrazolidine or pyrazole compounds which exhibit mild antimicrobial effects against various strains of bacteria.

Biological Activity

kobe2602 is a small-molecule inhibitor of ras with ki value of 149 μm [1].kobe2602 is a compound screened out by a computer-assisted search of about 160,000 compounds. it dose-dependently inhibited the binding of h-rasg12v to c-raf-1 in nih 3t3 cells with a rough ic50 value of 10 μm. 20 μm of kobe2602 effectively suppressed the phosphorylation of down-stream kinases of raf, including mek and erk. besides that, in nih 3t3 cells transfected with h-rasg12v, kobe2602 inhibited the colony formation with ic50 value of 1.4 μm. kobe2602 also showed effect on other cancer cells carrying activated ras oncogenes, such as panc-1(k-rasg12v), ht1080 (n-rasq61l) and hct116 (h-rasg13d). moreover, in mice bearing sw480 xenografts, administration of kobe2602 resulted in 40-50% inhibition of the tumor growth at dose of 80 mg/kg [1].

in vivo

Kobe2602 (80 mg/kg; p.o.; five consecutive days per week; for 17 days) exhibits antitumor activity on a xenograft of human colon carcinoma SW480 cells carrying the K-RasG12V gene[1].

Animal Model:Female athymic nude mice (6-8 wk old), with SW480 cells xenograft[1]
Dosage:80 mg/kg
Administration:Oral administration, five consecutive days per week, for 17 days
Result:Caused inhibition of the tumor growth.

References

[1] shima f, yoshikawa y, ye m, et al. in silico discovery of small-molecule ras inhibitors that display antitumor activity by blocking the ras–effector interaction. proceedings of the national academy of sciences, 2013, 110(20): 8182-8187.

kobe-2602 Preparation Products And Raw materials

Raw materials

Preparation Products

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kobe-2602 Suppliers

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View Lastest Price from kobe-2602 manufacturers

Career Henan Chemical Co
Product
KOBE-2602 454453-49-7
Price
US $1.00/ASSAYS
Min. Order
1ASSAYS
Purity
96%
Supply Ability
10kg
Release date
2019-09-04

454453-49-7, kobe-2602Related Search:


  • kobe 2602
  • kobe2602
  • kobe-2602
  • 2-[2,6-Dinitro-4-(trifluoroMethyl)phenyl]-N-(4-fluorophenyl)hydrazinecarbothioaMide
  • kobe-2602 2-[2,6-Dinitro-4-(trifluoromethyl)phenyl]-N-(4-fluorophenyl)hydrazinecarbothioamide
  • Kobe 2602, >=98%
  • kobe2602, >96%
  • CS-1280
  • KOBE 2602; KOBE-2602
  • Hydrazinecarbothioamide, 2-[2,6-dinitro-4-(trifluoromethyl)phenyl]-N-(4-fluorophenyl)-
  • H-Ras,Inhibitor,antiproliferative,Kobe-2602,carcinoma,Kobe 2602,Kobe2602,inhibit,Ras,Raf
  • Kos2602
  • Kobe2602, 10 mM in DMSO
  • Kobe2602 ，S6527
  • 454453-49-7
  • C14H9F4N5O4S
  • Inhibitors
  • Aromatics, Miscellaneous Reagents, Pharmaceuticals, Intermediates & Fine Chemicals