Benzonitrile, 4-[[(1R,2R)-2-[(3R)-3-aMino-1-piperidinyl]-2,3-dihydro-1H-inden-1-yl]oxy]-3-chloro-

Product Name: Benzonitrile, 4-[[(1R,2R)-2-[(3R)-3-aMino-1-piperidinyl]-2,3-dihydro-1H-inden-1-yl]oxy]-3-chloro-
CAS No.: 1333210-07-3
Chemical Name: Benzonitrile, 4-[[(1R,2R)-2-[(3R)-3-aMino-1-piperidinyl]-2,3-dihydro-1H-inden-1-yl]oxy]-3-chloro-
Synonyms: SAR7334;TRCP6-IN-1;TRCP6 inhibitor;SAR7334,SAR 7334,TRP Channel,SAR-7334,Inhibitor,inhibit,Transient receptor potential channels;4-(((1R,2R)-2-((R)-3-Aminopiperidin-1-yl)-2,3-dihydro-1H-inden-1-yl)oxy)-3-chlorobenzonitrile;Benzonitrile, 4-[[(1R,2R)-2-[(3R)-3-aMino-1-piperidinyl]-2,3-dihydro-1H-inden-1-yl]oxy]-3-chloro-
CBNumber: CB72668052
Molecular Formula: C21H22ClN3O
Formula Weight: 367.87
MOL File: 1333210-07-3.mol

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Benzonitrile, 4-[[(1R,2R)-2-[(3R)-3-aMino-1-piperidinyl]-2,3-dihydro-1H-inden-1-yl]oxy]-3-chloro- Property

Boiling point:: 534.6±50.0 °C(Predicted)
Density: 1.30±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: insoluble in H2O; ≥106.4 mg/mL in EtOH; ≥125.4 mg/mL in DMSO
form: Solid
pka: 10.95±0.20(Predicted)
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Tocris

Product number: 5831
Product name: SAR7334
Purity: ≥98%(HPLC)
Packaging: 5
Price: $283
Updated: 2021/12/16

ChemScene

Product number: CS-3902
Product name: SAR7334
Purity: 99.91%
Packaging: 5mg
Price: $230
Updated: 2021/12/16

ApexBio Technology

Product number: B1189
Product name: SAR7334
Packaging: 2mg
Price: $326
Updated: 2021/12/16

ChemScene

Product number: CS-3902
Product name: SAR7334
Purity: 99.91%
Packaging: 10mg
Price: $400
Updated: 2021/12/16

ApexBio Technology

Product number: B1189
Product name: SAR7334
Packaging: 5mg
Price: $488
Updated: 2021/12/16

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Benzonitrile, 4-[[(1R,2R)-2-[(3R)-3-aMino-1-piperidinyl]-2,3-dihydro-1H-inden-1-yl]oxy]-3-chloro- Chemical Properties,Usage,Production

Uses

SAR7334 is a potent and specific TRPC6 inhibitor, inhibiting TRPC6 currents with IC50 of 7.9 nM.

Biological Activity

sar7334 is a potent trpc6(transient receptor potential cation channel, subfamily c, member 6) inhibitor.

in vivo

SAR7334 (10?mg/kg, p.o.) suppresses TRPC6-dependent acute HPV in isolated perfused lungs from mice. SAR7334 demonstrates that it is suitable for chronic oral administration. In an initial short-term study, SAR7334 does not change mean arterial pressure in spontaneously hypertensive rats (SHR)^[3].

References

[1] Ilatovskaya DV, et al. The Role of Angiotensin II in Glomerular Volume Dynamics and Podocyte Calcium Handling. Sci Rep. 2017 Mar 22;7(1):299. DOI:10.1038/s41598-017-00406-2
[2] Chauvet S, et al. Pharmacological Characterization of the Native Store-Operated Calcium Channels of Cortical Neurons from Embryonic Mouse Brain. Front Pharmacol. 2016 Dec 12;7:486. DOI:10.3389/fphar.2016.00486
[3] Maier T, et al. Discovery and pharmacological characterization of a novel potent inhibitor of diacylglycerol-sensitive TRPC cation channels. Br J Pharmacol. 2015 Jul;172(14):3650-60. DOI:10.1111/bph.13151

Benzonitrile, 4-[[(1R,2R)-2-[(3R)-3-aMino-1-piperidinyl]-2,3-dihydro-1H-inden-1-yl]oxy]-3-chloro- Preparation Products And Raw materials

Raw materials

Preparation Products

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Benzonitrile, 4-[[(1R,2R)-2-[(3R)-3-aMino-1-piperidinyl]-2,3-dihydro-1H-inden-1-yl]oxy]-3-chloro- Suppliers

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1333210-07-3, Benzonitrile, 4-[[(1R,2R)-2-[(3R)-3-aMino-1-piperidinyl]-2,3-dihydro-1H-inden-1-yl]oxy]-3-chloro-Related Search:

Benzonitrile, 4-[[(1R,2R)-2-[(3R)-3-aMino-1-piperidinyl]-2,3-dihydro-1H-inden-1-yl]oxy]-3-chloro-

TRCP6 inhibitor

TRCP6-IN-1

4-(((1R,2R)-2-((R)-3-Aminopiperidin-1-yl)-2,3-dihydro-1H-inden-1-yl)oxy)-3-chlorobenzonitrile

SAR7334

SAR7334,SAR 7334,TRP Channel,SAR-7334,Inhibitor,inhibit,Transient receptor potential channels

1333210-07-3