AZD1656

Product Name: AZD1656
CAS No.: 919783-22-5
Chemical Name: AZD1656
Synonyms: AZD1656;AZD 1656;AZD-1656;AZD-2691;AZ-12501796;AZD-1656, 10 mM in DMSO;3-[5-(azetidine-1-carbonyl)pyrazin-2-yl]oxy-5-[(2S)-1-methoxypropan-2-yl]oxy-N-(5-methylpyrazin-2-yl)benzamide;(S)-3-((5-(Azetidine-1-carbonyl)pyrazin-2-yl)oxy)-5-((1-methoxypropan-2-yl)oxy)-N-(5-methylpyrazin-2-yl)benzamide;Benzamide, 3-[[5-(1-azetidinylcarbonyl)-2-pyrazinyl]oxy]-5-[(1S)-2-methoxy-1-methylethoxy]-N-(5-methyl-2-pyrazinyl)-;Hexokinase IV,Glucokinase,AZD-1656,AZD1656,G6pc,G6P,ChREBP-β,hypoglycemia,inhibit,Inhibitor,Hexokinase D,epinephrine,glucagon,antihyperglycemic
CBNumber: CB72668128
Molecular Formula: C24H26N6O5
Formula Weight: 478.5
MOL File: 919783-22-5.mol

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AZD1656 Property

Boiling point:: 635.0±55.0 °C(Predicted)
Density: 1.336±0.06 g/cm3(Predicted)
solubility: DMSO: Soluble: =10 mg/ml
Ethanol: Slightly soluble: 0.1-1 mg/ml
form: Solid
pka: 10.84±0.70(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H360May damage fertility or the unborn child

H372Causes damage to organs through prolonged or repeated exposure

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P314Get medical advice/attention if you feel unwell.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Axon Medchem

Product number: Axon3062
Product name: AZD1656
Purity: 99%
Packaging: 5mg
Price: $181.5
Updated: 2021/12/16

Biosynth Carbosynth

Product number: BA171838
Product name: AZD 1656
Packaging: 10mg
Price: $340
Updated: 2021/12/16

ChemScene

Product number: CS-0008226
Product name: AZD1656
Packaging: 5mg
Price: $370
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: KIN0008617
Product name: (S)-3-((5-(AZETIDINE-1-CARBONYL)PYRAZIN-2-YL)OXY)-5-((1-METHOXYPROPAN-2-YL)OXY)-N-(5-METHYLPYRAZIN-2-YL)BENZAMIDE
Purity: 95.00%
Packaging: 5MG
Price: $504.48
Updated: 2021/12/16

ChemScene

Product number: CS-0008226
Product name: AZD1656
Packaging: 10mg
Price: $600
Updated: 2021/12/16

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AZD1656 Chemical Properties,Usage,Production

Uses

AZD1656 is a potent, selective and orally active glucokinase activator with an EC50 of 60 nM. AZD1656 has the potential for type 2 diabetes research[1][2][3].

in vivo

AZD1656 (0-9 mg/kg; oral gavage; daily; for 8 weeks; C57BL/6 mice) treatment shows lowered blood glucose and glucose excursion and raised insulin. Liver mRNA levels for various ChREBP target genes including carbohydrate response element binding protein beta isoform (ChREBP-β), G6pc, Pklr, Acly, Acac and Gpd2 are increased by AZD1656^[1].

Animal Model:	C57BL/6 mice^[1]
Dosage:	0 mg/kg, 2 mg/kg, 4.5 mg/kg, 9 mg/kg
Administration:	Oral gavage; daily; for 8 weeks
Result:	Administered 2 hours before the oral glucose tolerance test, lowered blood glucose and glucose excursion and raised insulin.

References

[1] Brian E Ford, et al. Chronic glucokinase activator treatment activates liver Carbohydrate response element binding protein and improves hepatocyte ATP homeostasis during substrate challenge. Diabetes Obes Metab. 2020 Jun 10. DOI:10.1111/dom.14111

[2] Medicinal Chemistry, et al. Design and Development of the Glucokinase Activator AZD1656. Complete Accounts of Integrated Drug Discovery and Development: Recent Examples from the Pharmaceutical Industry Volume 1, 185-220.

[3] Terri Mitchard, et al. The novel use of a heterozygous knockout mouse for embryofetal development assessment of a glucokinase activator. Birth Defects Res B Dev Reprod Toxicol. 2014 Apr;101(2):152-61. DOI:10.1002/bdrb.21102
[4] M. WARING. Property based optimisation of glucokinase activators – discovery of the phase IIb clinical candidate AZD1656[J]. MedChemComm, 2012, 3 1: 1077-1081. DOI: 10.1039/c2md20077e

AZD1656 Preparation Products And Raw materials

Raw materials

Preparation Products

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AZD1656 Suppliers

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919783-22-5, AZD1656Related Search:

AZD 1656

AZD1656

AZD-1656

3-[5-(azetidine-1-carbonyl)pyrazin-2-yl]oxy-5-[(2S)-1-methoxypropan-2-yl]oxy-N-(5-methylpyrazin-2-yl)benzamide

Benzamide, 3-[[5-(1-azetidinylcarbonyl)-2-pyrazinyl]oxy]-5-[(1S)-2-methoxy-1-methylethoxy]-N-(5-methyl-2-pyrazinyl)-

Hexokinase IV,Glucokinase,AZD-1656,AZD1656,G6pc,G6P,ChREBP-β,hypoglycemia,inhibit,Inhibitor,Hexokinase D,epinephrine,glucagon,antihyperglycemic

(S)-3-((5-(Azetidine-1-carbonyl)pyrazin-2-yl)oxy)-5-((1-methoxypropan-2-yl)oxy)-N-(5-methylpyrazin-2-yl)benzamide

AZD-1656, 10 mM in DMSO

AZ-12501796

AZD-2691

919783-22-5