GSK1265744 (sodiuM salt)

Product Name: GSK1265744 (sodiuM salt)
CAS No.: 1051375-13-3
Chemical Name: GSK1265744 (sodiuM salt)
Synonyms: Sodium Cabotegravir;Cabotegravir Sodium;GSK1265744 (sodiuM salt);GSK1265744 (GSK744) Sodium salt;GSK1265744 (sodiuM salt) ISO 9001：2015 REACH;Sodium (3S,11aR)-8-((2,4-difluorobenzyl)carbamoyl)-3-methyl-5,7-dioxo-2,3,5,7,11,11a-hexahydrooxazolo[3,2-a]pyrido[1,2-d]pyrazin-6-olate;(3S,11AR)-N-(2,4-DIFLUOROBENZYL)-6-HYDROXY-3-METHYL-5,7-DIOXO-2,3,5,7,11,11A-HEXAHYDROOXAZOLO[3,2-A]PYRIDO[1,2-D]PYRAZINE-8-CARBOXAMIDE, SODIUM SALT
CBNumber: CB72668193
Molecular Formula: C19H18F2N3NaO5
Formula Weight: 429.36
MOL File: 1051375-13-3.mol

More

Less

GSK1265744 (sodiuM salt) Property

storage temp.: 4°C, away from moisture
solubility: DMSO : 6.9 mg/mL (16.15 mM; ultrasonic and warming and heat to 60°C)
form: Solid
color: White to off-white

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H400Very toxic to aquatic life

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

P391Collect spillage. Hazardous to the aquatic environment

P501Dispose of contents/container to..…

More

Less

N-Bromosuccinimide Price

Biorbyt Ltd

Product number: orb611943
Product name: Cabotegravir Sodium
Purity: >98%
Packaging: 100mg
Price: $765
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb611943
Product name: Cabotegravir Sodium
Purity: >98%
Packaging: 250mg
Price: $1356.6
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb611943
Product name: Cabotegravir Sodium
Purity: >98%
Packaging: 1g
Price: $2691.1
Updated: 2021/12/16

DC Chemicals

Product number: DC26013
Product name: CabotegravirSodium
Purity: >98%
Packaging: 1g
Price: $1800
Updated: 2021/12/16

Crysdot

Product number: CD11359572
Product name: Sodium(3S,11aR)-8-((2,4-difluorobenzyl)carbamoyl)-3-methyl-5,7-dioxo-2,3,5,7,11,11a-hexahydrooxazolo[3,2-a]pyrido[1,2-d]pyrazin-6-olate
Purity: 97%
Packaging: 100mg
Price: $218
Updated: 2021/12/16

More

Less

GSK1265744 (sodiuM salt) Chemical Properties,Usage,Production

Uses

Cabotegravir (GSK-1265744) sodium is a orally active and long-acting HIV integrase strand transfer inhibitor and organic anion transporter 1/3 (OAT1/OAT3) inhibitor with IC50 values of 2.5 nM, 0.41 μM and 0.81 μM for HIVADA, OAT3 and OAT1, respectively. Cabotegravir sodium is primarily metabolized by uridine diphosphate glucuronosyltransferase (UGT) 1A1, with low potential to interact with other antiretroviral agents (ARVs). Cabotegravir sodium can be used to research AIDS[1][2].

Definition

ChEBI: Cabotegravir sodium is an organic sodium salt that is the monosodium salt of cabotegravir. Used for treatment of HIV-1. It has a role as a HIV-1 integrase inhibitor. It contains a cabotegravir(1-).

in vivo

The half-life of Cabotegravir is up to 54 days in mice^[1].
Cabotegravir (25 or 50 mg/kg; i.v.; single dose or twice) protects Macaques against intravenous challenge with SIVmac251^[4].

References

[1] Zhou T, et al. Creation of a nanoformulated cabotegravir prodrug with improved antiretroviral profiles. Biomaterials. 2018 Jan;151:53-65. DOI:10.1016/j.biomaterials.2017.10.023
[2] Reese MJ, et al. Drug interaction profile of the HIV integrase inhibitor cabotegravir: assessment from in vitro studies and a clinical investigation with midazolam. Xenobiotica. 2016;46(5):445-56. DOI:10.3109/00498254.2015.1081993
[3] Yoshinaga T, et al. Antiviral characteristics of GSK1265744, an HIV integrase inhibitor dosed orally or by long-acting injection. Antimicrob Agents Chemother. 2015 Jan;59(1):397-406. DOI:10.1128/AAC.03909-14
[4] Andrews CD, et al. Cabotegravir long acting injection protects macaques against intravenous challenge with SIVmac251. AIDS. 2017 Feb 20;31(4):461-467. DOI:10.1097/QAD.0000000000001343

GSK1265744 (sodiuM salt) Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

GSK1265744 (sodiuM salt) Suppliers

China 35 India 2 United States 4 Global 41

Shenzhen HwaGen Pharmaceutical Co.,Ltd

Tel: 17722620669
Fax: 0752-5319394
Email: liangcong.yi@rafflespt.com
Country: China
ProdList: 279
Advantage: 58

Taizhou Tongxin Bio-Tech Co., Ltd

Tel: 0523-86818997 18652728585
Email: sales@allyrise.com
Country: China
ProdList: 2966
Advantage: 60

Taizhou Ruixin Chemical Co., Ltd.

Tel: 0576-89085261 15867635987
Fax: 0576-89085262
Email: jasonhu09@163.com
Country: China
ProdList: 442
Advantage: 50

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

Shanghai Chaolan Chemical Technology Center

Tel: 021-QQ：65489617 15618227136
Fax: 21-5161 9052
Email: Sales@ATKchemical.com
Country: China
ProdList: 9125
Advantage: 58

Shanghai Zhen Li Biological Technology Co., Ltd

Tel: 021-16621358918; 18516310516
Fax: 13045646768
Email: zhenlipharma888@163.com
Country: China
ProdList: 19035
Advantage: 58

Changzhou Yongfeng Biomedicine Co. Ltd.

Tel: 15006117673
Fax: 2973592490@.com
Email: 2973592490@qq.com
Country: China
ProdList: 299
Advantage: 58

Hefei TNJ Chemical Industry Co.,Ltd.

Tel: +86-0551-65418684 +8618949823763
Fax: 0086-551-65418684
Email: sales@tnjchem.com
Country: China
ProdList: 25356
Advantage: 58

Dideu Industries Group Limited

Tel: +86-29-89586680 +86-15129568250
Email: 1026@dideu.com
Country: China
ProdList: 20284
Advantage: 58

Shanxi Xuanran Import and Export Trade Co., Ltd.

Tel: +8617735180244
Email: mike_yan@xuanranglobal.com
Country: CHINA
ProdList: 4017
Advantage: 58

Shanghai Yanze Chemical Co., Ltd.

Tel: 021-021-13773155751 19975051755
Email: 260924549@qq.com
Country: China
ProdList: 10524
Advantage: 58

career henan chemical co

Tel: +86-0371-86658258 +8613203830695
Fax: 0086-371-86658258
Email: factory@coreychem.com
Country: China
ProdList: 29798
Advantage: 58

Absin Bioscience Inc.

Tel: 021-38015121 18438616290
Email: lanwu@univ-bio.com
Country: China
ProdList: 24731
Advantage: 58

Chunchuang (Wuhan) Technology Co., Ltd

Tel: 15727060112
Email: yutianchun2007@126.com
Country: China
ProdList: 9814
Advantage: 58

Shanghai Dexuan Pharmaceutical Technology Co., Ltd

Tel: 1701086315
Fax: 1701086315@qq.com
Email: dexuanpharma@126.com
Country: China
ProdList: 9475
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-1647117 13681763483
Email: product02@bidepharm.com
Country: China
ProdList: 59936
Advantage: 58

Wuhan Shanhai Zhihe Biotechnology Co., Ltd.

Tel: 17771424646
Email: shoubull@126.com
Country: China
ProdList: 957
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24961
Advantage: 58

Shaanxi Didu New Material Co., Ltd

Tel: 029-81145920 17391631969
Email: 1046@dideu.com
Country: China
ProdList: 9996
Advantage: 58

Shanghai?Medlife?Pharm-Tech?Co.,?Ltd

Tel: 021-59167510 18117107507
Email: vip@med-life.cn
Country: China
ProdList: 5002
Advantage: 58

Jiangxi Puxin Biotechnology Co., Ltd

Tel: 15867635987
Email: jasonhu09@163.com
Country: China
ProdList: 796
Advantage: 58

Nanjing Shizhou Biology Technology Co.,Ltd

Tel: 17301488900
Fax: 025-85560043
Email: judy.xia@synzest.com
Country: China
ProdList: 12582
Advantage: 58

Chongqing gongzhou pharmaceutical technology co. LTD

Tel: 23-65788716 18996150726
Email: 123471430@qq.com
Country: China
ProdList: 24
Advantage: 58

RD International Technology Co., Limited

Tel: 18024082417
Email: market@ubiochem.com
Country: China
ProdList: 9835
Advantage: 58

Biosynth Biological Technology (Suzhou) Co Ltd

Tel: 51288865780
Email: sales@biosynth.com
Country: China
ProdList: 6051
Advantage: 58

Adooq Bioscience LLC

Tel: 400-025-6535
Email: sales@adooq.cn
Country: China
ProdList: 6215
Advantage: 58

Selleck Chemicals

Tel: 400-668-6834
Email: info@selleck.cn
Country: China
ProdList: 6071
Advantage: 58

Changzhou Xuanming Pharmaceutical Technology Co., Ltd.

Tel: +86-519-85525359 +86-15995072465
Email: sales@xuanmingchem.com
Country: China
ProdList: 912
Advantage: 58

Chongqing jooe co., ltd

Tel: +undefined86-15223382610
Email: info@jooe.com
Country: China
ProdList: 6208
Advantage: 58

Guangzhou Tengyue Chemical Co., Ltd.

Tel: +86-86-18148706580 +8618826483838
Email: evan@tyvovo.com
Country: China
ProdList: 143
Advantage: 58

Zhengzhou Anbu Chem Co.,Ltd

Tel: +86-0371-88006763; +8615988602810
Email: sales@anbuchem.com
Country: China
ProdList: 3002
Advantage: 58

Hangzhou MolCore BioPharmatech Co.,Ltd.

Tel: +86-057181025280; +8617767106207
Fax: 0571-85806285
Email: sales@molcore.com
Country: China
ProdList: 49734
Advantage: 58

Shenzhen Shengda Pharma Limited

Tel: 755-85269922 +8613424394241
Fax: WeChat:shengdapharm
Email: sales@shengdapharm.com
Country: CHINA
ProdList: 310
Advantage: 58

Biorbyt Ltd.

Tel: --
Fax: --
Email: info@biorbyt.com
Country: CHINA
ProdList: 6482
Advantage: 58

Guangdong Raffles Pharmaceutical Technology Co., Ltd.

Tel: --
Fax: --
Email: sales@rafflespt.com
Country: CHINA
ProdList: 100
Advantage: 58

More

Less

View Lastest Price from GSK1265744 (sodiuM salt) manufacturers

Guangzhou Tengyue Chemical Co., Ltd.

Product: CABOTEGRAVIR SODIUM; GSK1265744 (sodiuM salt) 1051375-13-3
Price: US $100.00-10.00/kg
Min. Order: 1kg
Purity: 99% Purity (What/sapp: +86 18145728414)
Supply Ability: 1000 Tons/Month
Release date: 2023-06-30

Career Henan Chemical Co

Product: GSK1265744 (sodiuM salt) 1051375-13-3
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2020-02-11

1051375-13-3, GSK1265744 (sodiuM salt)Related Search:

GSK1265744 (sodiuM salt)

Cabotegravir Sodium

(3S,11AR)-N-(2,4-DIFLUOROBENZYL)-6-HYDROXY-3-METHYL-5,7-DIOXO-2,3,5,7,11,11A-HEXAHYDROOXAZOLO[3,2-A]PYRIDO[1,2-D]PYRAZINE-8-CARBOXAMIDE, SODIUM SALT

Sodium Cabotegravir

GSK1265744 (sodiuM salt) ISO 9001：2015 REACH

Sodium (3S,11aR)-8-((2,4-difluorobenzyl)carbamoyl)-3-methyl-5,7-dioxo-2,3,5,7,11,11a-hexahydrooxazolo[3,2-a]pyrido[1,2-d]pyrazin-6-olate

GSK1265744 (GSK744) Sodium salt

1051375-13-3

051375-13-3