ChemicalBook > CAS DataBase List > (S)-(-)-WARFARIN

(S)-(-)-WARFARIN

Product Name
(S)-(-)-WARFARIN
CAS No.
5543-57-7
Chemical Name
(S)-(-)-WARFARIN
Synonyms
Warfarin,R-;(S)-WARFARIN;(S)-(-)-WARFARIN;Warfarin S-Isomer;Warfarin Impurity 17;Warfarin Impurity 17（Warfarin S-Isomer）;s-(-)-3-acetonybenzyl)-4-hydroxycoumarin;S-(-)-3-(ACETONYLBENZYL)-4-HYDROXYCOUMARIN;Warfarin sodium Impurity 23 ((S)-Warfarin);2-hydroxy-3-(3-keto-1-phenyl-butyl)chromone
CBNumber
CB7267099
Molecular Formula
C19H16O4
Formula Weight
308.33
MOL File
5543-57-7.mol
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(S)-(-)-WARFARIN Property

Melting point:
≥170 °C
storage temp. 
2-8°C
solubility 
DMF: 25 mg/ml; DMSO: 25 mg/ml; Ethanol: 5 mg/ml
form 
A crystalline solid
color 
white to pale yellow
CAS DataBase Reference
5543-57-7(CAS DataBase Reference)
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Safety

Hazard Codes 
T
Risk Statements 
61-48/25-52/53
Safety Statements 
53-45-61
RIDADR 
UN 2811 6.1/PG 1
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H372Causes damage to organs through prolonged or repeated exposure

H411Toxic to aquatic life with long lasting effects

Precautionary statements

P202Do not handle until all safety precautions have been read and understood.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
UC214
Product name
(S)-(?)-Warfarin
Purity
≥97% (HPLC)
Packaging
5mg
Price
$918
Updated
2024/03/01
Sigma-Aldrich
Product number
UC214
Product name
(S)-(?)-Warfarin
Purity
≥97% (HPLC)
Packaging
10mg
Price
$1660
Updated
2024/03/01
Cayman Chemical
Product number
13531
Product name
(-)-Warfarin
Purity
≥98%
Packaging
1mg
Price
$74
Updated
2024/03/01
Cayman Chemical
Product number
13531
Product name
(-)-Warfarin
Purity
≥98%
Packaging
5mg
Price
$241
Updated
2024/03/01
Cayman Chemical
Product number
13531
Product name
(-)-Warfarin
Purity
≥98%
Packaging
10mg
Price
$444
Updated
2024/03/01
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(S)-(-)-WARFARIN Chemical Properties,Usage,Production

Description

(–)-Warfarin is a component of (±)-warfarin . It is an anticoagulant that interferes with interconversion of vitamin K and vitamin K epoxide and the role of vitamin K in carboxylation of several clotting cascade proteins, inhibiting the initiation of clotting. In vivo, (–)-warfarin slows formation of the prothrombin complex and exhibits 6.6-fold more potent anticoagulant activity than (+)-warfarin in rats. (–)-Warfarin is primarily metabolized by the cytochrome P450 (CYP) isoform CYP2C9 and genetic polymorphisms in this enyzme, as well as other compounds metabolized by CYP2C9, increase the potential for catastrophic bleeding complications. Formulations containing warfarin have been used to treat and prevent blood clots in atrial fibrillation, heart valve replacement, venous thrombosis, and pulmonary embolism.

Chemical Properties

White Solid

Uses

The S-(-)-form of Warfarin (W498500). Coumarin anticoagulant.

Uses

(S)-(?)-Warfarin has been used in cell cultures.

Definition

ChEBI: (S)-warfarin is a 4-hydroxy-3-(3-oxo-1-phenylbutyl)-2H-1-benzopyran-2-one that has (S)-configuration (the racemate is warfarin, an anticoagulant drug and rodenticide). It is a conjugate acid of a (S)-warfarin(1-). It is an enantiomer of a (R)-warfarin.

General Description

Warfarin is an antagonist of vitamin K. It is an oral coumarin anticoagulant.

Biochem/physiol Actions

Warfarin is used to regulate and inhibit thromboembolic disorders. The CYP2C9 (cytochrome P450 family 2 subfamily C member 9)?protein plays a major role in the inactivation of potent S-warfarin.

(S)-(-)-WARFARIN Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from (S)-(-)-WARFARIN manufacturers

Career Henan Chemica Co
Product
(S)-(-)-WARFARIN 5543-57-7
Price
US $0.37/KG
Min. Order
1KG
Purity
99%
Supply Ability
10kg/100kg
Release date
2020-11-09

5543-57-7, (S)-(-)-WARFARINRelated Search:

Warfarin 4-Hydroxycoumarin 4,4'-(Disulfanediyl)bis(2,6-di-tert-butylphenol) (S)-8-Hydroxy Warfarin 6-HYDROXYWARFARIN (R)-6-Hydroxy Warfarin 3-(o-Hydroxyphenyl)-5-phenyl-2-cyclohexen-1-one Benzalacetone 3-[α-(2-Hydroxypropyl)benzyl]-4-hydroxycouMarin (R)-7-Hydroxy Warfarin 7-HYDROXYWARFARIN (S)-6-Hydroxy Warfarin Warfarin Impurity 1 8-HYDROXYWARFARIN 2,6-Di-tert-butyl-4-mercaptophenol 7-HYDROXYWARFARIN (R)-(+)-WARFARIN,(R)-WARFARIN (R)-8-HYDROXY WARFARIN

  • Coumarin, 3-(a-acetonylbenzyl)-4-hydroxy-, (S)-(-)- (8CI)
  • 4-Hydroxy-3-(3-oxo-1-phenyl-butyl)-chromen-2-one
  • S-(-)-3-Acetonybenzyl)-4-hydroxycoumarin, S-(-)-4-Hydroxy-3-(3-oxo-1-phenybutyl)-2H-1-benzopyran-2-one
  • (-)-3-[(S)-1-Phenyl-3-oxobutyl]-4-hydroxycoumarin
  • (-)-3-[(S)-α-Acetonylbenzyl]-4-hydroxycoumarin
  • (-)-4-Hydroxy-3-[(S)-3-oxo-1-phenylbutyl]-2H-1-benzopyran-2-one
  • 2-hydroxy-3-(3-keto-1-phenyl-butyl)chromone
  • 2-hydroxy-3-(3-oxo-1-phenylbutyl)-1-benzopyran-4-one
  • 4-Hydroxy-3-[(1S)-3-oxo-1-phenylbutyl]-2H-1-benzopyran-2-one
  • (S)-(-)-WARFARIN
  • (S)-WARFARIN
  • (S)-(+)-4-HYDROXY-3-(3-OXO-1-PHENYBUTYL)-2H-1-BENZOPYRAN-2-ONE
  • S-(-)-4-HYDROXY-3-(3-OXO-1-PHENYBUTYL)-2H-1-BENZOPYRAN-2-ONE
  • (S)-(+)-4-HYDROXY-3-(3-OXO-1-PHENYLBUTYL)-2H-1-BENZOPYRAN-2-ONE
  • S-(-)-3-(ACETONYLBENZYL)-4-HYDROXYCOUMARIN
  • (S)-4-hydroxy-3-(3-oxo-1-phenylbutyl)-2-benzopyrone
  • Warfarin,R-
  • (S)-4-Hydroxy-3-(3-oxo-1-phenylbutyl)-2H-chromen-2-one
  • 4-HYDROXY-3-((S)-3-OXO-1-PHENYL-BUTYL)-CHROMEN-2-ONE
  • s-(-)-3-acetonybenzyl)-4-hydroxycoumarin
  • 2H-1-Benzopyran-2-one, 4-hydroxy-3-(3-oxo-1-phenylbutyl)-, (S)-
  • 2H-1-Benzopyran-2-one, 4-hydroxy-3-[(1S)-3-oxo-1-phenylbutyl]- (9CI)
  • Warfarin S-Isomer
  • Warfarin Impurity 17（Warfarin S-Isomer）
  • Warfarin Impurity 17
  • S-(-)-WarfarinQ: What is S-(-)-Warfarin Q: What is the CAS Number of S-(-)-Warfarin Q: What is the storage condition of S-(-)-Warfarin Q: What are the applications of S-(-)-Warfarin
  • Warfarin sodium Impurity 23 ((S)-Warfarin)
  • 5543-57-7
  • C19H16O4
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Aromatics
  • Chiral Reagents
  • Heterocycles