AMpicillin-d5 Property

solubility 

Water: Slightly Soluble

form 

A solid

color 

White to off-white

Stability:

Hygroscopic

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H315Causes skin irritation

H317May cause an allergic skin reaction

H319Causes serious eye irritation

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P272Contaminated work clothing should not be allowed out of the workplace.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P284Wear respiratory protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P342+P311IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.

P363Wash contaminated clothing before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

AMpicillin-d5 Chemical Properties,Usage,Production

Description

Ampicillin-d₅ is intended for use as an internal standard for the quantification of ampicillin by GC- or LC-MS. Ampicillin is a broad-spectrum antibiotic with activity against Gram-positive and Gram-negative bacteria, including veterinary isolates of S. pseudintermedius, S. aureus, E. coli, Pasteurella, and S. canis (MIC₅₀s = 0.25, 0.5, 2, 0.12, and 0.25 μg/ml, respectively).¹ In vivo, ampicillin (80 mg/kg, i.v.) reduces cough frequency, tachypnea, dyspnea, and fever and increases survival in a baboon (P. cynocephalus) model of pneumococcal pneumonia.² Formulations containing ampicillin have been used to treat a variety of bacterial infections.

Uses

Labelled Ampicillin. Orally active, semi-synthetic antibiotic

References

1. Awji, E.G., Damte, D., Lee, S.-J., et al. The in vitro activity of 15 antimicrobial agents against bacterial isolates from dogs J. Vet. Med. Sci. 74(8),1091-1094(2012).
2. Reyes, L.F., Restrepo, M.I., Hinojosa, C.A., et al. A non-human primate model of severe pneumococcal pneumonia PLoS One 11(11),e0166092(2016).