EMpagliflozin-d4
- Product Name
- EMpagliflozin-d4
- CAS No.
- 2749293-95-4
- Chemical Name
- EMpagliflozin-d4
- Synonyms
- EMpagliflozin-d4
- CBNumber
- CB72674183
- Molecular Formula
- C23H23ClD4O7
- Formula Weight
- 454.93
- MOL File
- 2749293-95-4.mol
EMpagliflozin-d4 Property
- Boiling point:
- 664.458±55.00 °C(Press: 760.00 Torr)(predicted)
- Density
- 1.399±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
- solubility
- DMSO: Solube
- pka
- 13.233±0.70(predicted)
- form
- Solid
- color
- White to off-white
N-Bromosuccinimide Price
- Product number
- 22369
- Product name
- Empagliflozin-d4
- Purity
- ≥99% deuterated forms (d1-d4)
- Packaging
- 500μg
- Price
- $227
- Updated
- 2024/03/01
- Product number
- 22369
- Product name
- Empagliflozin-d4
- Purity
- ≥99% deuterated forms (d1-d4)
- Packaging
- 1mg
- Price
- $404
- Updated
- 2024/03/01
- Product number
- E521512
- Product name
- Empagliflozin-d4
- Packaging
- 5mg
- Price
- $2900
- Updated
- 2021/12/16
- Product number
- D75335
- Product name
- Empagliflozin-d4
- Packaging
- 1mg
- Price
- $890
- Updated
- 2021/12/16
EMpagliflozin-d4 Chemical Properties,Usage,Production
Uses
Empagliflozin-d4 is deuterium labeled Empagliflozin. Empagliflozin (BI 107730 is a selective sodium glucose cotransporter-2 (SGLT-2) inhibitor with an IC50 of 3.1 nM for human SGLT-2[1].
References
[1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. DOI:10.1177/1060028018797110
[2] Grempler R, et al. Empagliflozin, a novel selective sodium glucose cotransporter-2 (SGLT-2) inhibitor: characterisation and comparison with other SGLT-2 inhibitors. Diabetes Obes Metab. 2012 Jan;14(1):83-90. DOI:10.1111/j.1463-1326.2011.01517.x
[3] Cheng ST, et al. The Effects of Empagliflozin, an SGLT2 Inhibitor, on Pancreatic β-Cell Mass and Glucose Homeostasis in Type 1 Diabetes. PLoS One. 2016 Jan 25;11(1):e0147391. DOI:10.1371/journal.pone.0147391
[4] Nikole J.ByrneBSc, et al. Empagliflozin Prevents Worsening of Cardiac Function in an Experimental Model of Pressure Overload-Induced Heart Failure. JACC Basic Transl Sci. 2017 Aug;2(4):347-354.
[5] Sakaeda T, et al. Susceptibility to serious skin and subcutaneous tissue disorders and skin tissue distribution of sodium-dependent glucose co-transporter type 2 (SGLT2) inhibitors. Int J Med Sci. 2018 Jun 13;15(9):937-943. DOI:10.7150/ijms.22224
[6] BOWEN LIN. Glycemic control with empagliflozin, a novel selective SGLT2 inhibitor, ameliorates cardiovascular injury and cognitive dysfunction in obese and type 2 diabetic mice.[J]. Cardiovascular Diabetology, 2014: 148. DOI: 10.1186/s12933-014-0148-1
EMpagliflozin-d4 Preparation Products And Raw materials
Raw materials
Preparation Products
EMpagliflozin-d4 Suppliers
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