4-Chloro-N1-methylbenzene-1,2-diamine
- Product Name
- 4-Chloro-N1-methylbenzene-1,2-diamine
- CAS No.
- 59681-66-2
- Chemical Name
- 4-Chloro-N1-methylbenzene-1,2-diamine
- Synonyms
- 2-Fluoro-48-(methylthio)pyridine;4-chloro-N1-methyl-1,2-Benzenediamine;4-Chloro-N1-methylbenzene-1,2-diamine;1,2-Benzenediamine, 4-chloro-N1-methyl-;tert-butyl 3-allyl-3-hydroxyazetidine-35-carboxylate
- CBNumber
- CB72676657
- Molecular Formula
- C7H9ClN2
- Formula Weight
- 156.61
- MOL File
- 59681-66-2.mol
4-Chloro-N1-methylbenzene-1,2-diamine Property
- Boiling point:
- 309.5±27.0 °C(Predicted)
- Density
- 1.272±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 5.49±0.11(Predicted)
- Appearance
- Light brown to brown Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
N-Bromosuccinimide Price
- Product number
- 2669AL
- Product name
- 4-Chloro-1-N-methylbenzene-1,2-diamine
- Packaging
- 250mg
- Price
- $162
- Updated
- 2021/12/16
- Product number
- A119180
- Product name
- 4-Chloro-N1-methylbenzene-1,2-diamine
- Purity
- 97%
- Packaging
- 100mg
- Price
- $52
- Updated
- 2021/12/16
- Product number
- BD259897
- Product name
- 4-Chloro-N1-methylbenzene-1,2-diamine
- Purity
- 97%
- Packaging
- 100mg
- Price
- $53
- Updated
- 2021/12/16
- Product number
- A119180
- Product name
- 4-Chloro-N1-methylbenzene-1,2-diamine
- Purity
- 97%
- Packaging
- 250mg
- Price
- $79
- Updated
- 2021/12/16
- Product number
- BD259897
- Product name
- 4-Chloro-N1-methylbenzene-1,2-diamine
- Purity
- 97%
- Packaging
- 250mg
- Price
- $79
- Updated
- 2021/12/16
4-Chloro-N1-methylbenzene-1,2-diamine Chemical Properties,Usage,Production
Synthesis
74-89-5
89-61-2
59681-66-2
1. 1,4-Dichloro-2-nitrobenzene (5 g, 26 mmol) was dissolved in an ethanol solution of 33% methylamine (20 mL), heated to 80 °C, and reacted for 15 hours. 2. After completion of the reaction, cooled to room temperature and removed the solvent under reduced pressure. 3. The crude product was used directly in the next step of the reaction. 4. Dissolve the crude product in ethanol (250 mL), add zinc powder (15 g), and slowly add 6N aqueous hydrochloric acid solution (40 mL) dropwise. 5. Stir the reaction for 3 hours at room temperature. 6. 6. After the reaction was completed, saturated sodium hydroxide solution was added slowly until the reaction solution became alkaline. 7. 7. Extract the aqueous layer with dichloromethane (3 x 100 mL). 8. 8. The organic layers were combined, washed with saturated brine and dried over anhydrous sodium sulfate. 9. The solvent was removed under pressure to afford the target product 4-chloro-N1-methylbenz-2-amine (1.7 g, 42% overall yield in two steps). 10. The product was analyzed by 1H NMR. 10. The product was characterized by 1H NMR (300 MHz, CDCl3): δ 2.84 (s, 3H), 6.54 (d, J = 6.0 Hz, 1H), 6.70 (d, J = 3.0 Hz, 1H), 6.79 (dd, J = 3.0,6.0 Hz, 1H).
References
[1] Patent: WO2004/74270, 2004, A2. Location in patent: Page 131-132
4-Chloro-N1-methylbenzene-1,2-diamine Preparation Products And Raw materials
Raw materials
Preparation Products
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