ChemicalBook > CAS DataBase List > AZ505

AZ505

Product Name: AZ505
CAS No.: 1035227-43-0
Chemical Name: AZ505
Synonyms: CS-2253;AZ-505;AZ 505;AZ505 free base;AZ505, 10 mM in DMSO;SMYD2 Inhibitor, AZ505;Histone Methyltransferase,AZ 505,inhibit,AZ505,Inhibitor,AZ-505;N-Cyclohexyl-3-(3,4-dichlorophenethylamino)-N-[2-[[2-[5-hydroxy-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-8-yl]ethyl]amin;N-Cyclohexyl-N3-[2-(3,4-dichlorophenyl)ethyl]-N-(2-{[2-(5-hydroxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-8-yl)ethyl]amino}ethyl)-alaninamide;N-Cyclohexyl-3-(3,4-dichlorophenethylamino)-N-[2-[[2-[5-hydroxy-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-8-yl]ethyl]amino]ethyl]propanamide;Propanamide, N-cyclohexyl-3-[[2-(3,4-dichlorophenyl)ethyl]amino]-N-[2-[[2-(3,4-dihydro-5-hydroxy-3-oxo-2H-1,4-benzoxazin-8-yl)ethyl]amino]ethyl]-
CBNumber: CB72677038
Molecular Formula: C29H38Cl2N4O4
Formula Weight: 577.54
MOL File: 1035227-43-0.mol

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AZ505 Property

Boiling point:: 782.5±60.0 °C(Predicted)
Density: 1.32±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Soluble in DMSO
form: crystalline solid
pka: 8.59±0.20(Predicted)
color: Off-white to light brown

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 5.31661
Product name: SMYD2Inhibitor,AZ505-CAS1035227-43-0-Calbiochem
Packaging: 5mg
Price: $179
Updated: 2022/05/15

Cayman Chemical

Product number: 16875
Product name: AZ 505
Purity: ≥98%
Packaging: 1mg
Price: $55
Updated: 2024/03/01

Cayman Chemical

Product number: 16875
Product name: AZ 505
Purity: ≥98%
Packaging: 5mg
Price: $197
Updated: 2024/03/01

Cayman Chemical

Product number: 16875
Product name: AZ 505
Purity: ≥98%
Packaging: 10mg
Price: $368
Updated: 2024/03/01

TRC

Product number: A795175
Product name: AZ505
Packaging: 5mg
Price: $240
Updated: 2021/12/16

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AZ505 Chemical Properties,Usage,Production

Uses

AZ505 is a potent inhibitor of SMYD2, which plays an important role in epigenetic signalling. Inhibiition of SMYD2 also functions as an activator of the tumor suppressor proteins.

Biological Activity

Potent and selective SMYD2 inhibitor in vitro and in vivo.

AZ505 is a potent and selective SET and MYND domain-containing protein SMYD2 inhibitor (IC50 = 120 nM) th at targets the substrate-binding site in a peptide substrate-competitive and cofactor SAM-uncompetitive manner, exhibiting no activity against lysine methyltransferases (KMTs) SMYD3, DOT1L, EZH2, GLP, G9A and SET7/9 (IC50 >83.3 μM). AZ505 downregulates p53 K370 monomethylation in U2OS cells (10h 10 μM) and delays cyst growth in early- (5 mg/kg/day i.p. from P7-P27) as well as later-stage (10 mg/kg via i.p. 3x per wk from P42-3.5 months, then 1x per wk from 3.5–6 months) Pkd1 conditional knockout mouse models in vivo.

IC 50

SMYD2

AZ505 Preparation Products And Raw materials

Raw materials

Preparation Products

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1035227-43-0, AZ505Related Search:

2-Aminoethyl(ethyl)amine N-Ethyl-3-methylaniline N-ethyl-pyrrolidone

N-Cyclohexyl-N3-[2-(3,4-dichlorophenyl)ethyl]-N-(2-{[2-(5-hydroxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-8-yl)ethyl]amino}ethyl)-alaninamide

N-Cyclohexyl-3-(3,4-dichlorophenethylamino)-N-[2-[[2-[5-hydroxy-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-8-yl]ethyl]amino]ethyl]propanamide

AZ-505;AZ 505

CS-2253

Propanamide, N-cyclohexyl-3-[[2-(3,4-dichlorophenyl)ethyl]amino]-N-[2-[[2-(3,4-dihydro-5-hydroxy-3-oxo-2H-1,4-benzoxazin-8-yl)ethyl]amino]ethyl]-

AZ505 free base

Histone Methyltransferase,AZ 505,inhibit,AZ505,Inhibitor,AZ-505

AZ505, 10 mM in DMSO

SMYD2 Inhibitor, AZ505

N-Cyclohexyl-3-(3,4-dichlorophenethylamino)-N-[2-[[2-[5-hydroxy-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-8-yl]ethyl]amin

1035227-43-0

C29H38Cl2N4O4