Boc-4-pinicalborane-L-phenylalanine

Product Name: Boc-4-pinicalborane-L-phenylalanine
CAS No.: 216439-76-8
Chemical Name: Boc-4-pinicalborane-L-phenylalanine
Synonyms: 216439-76-8;Boc-4-Pinicalborane-L-Phe-OH;Boc-4-pinicalborane-L-phenylalanine;Boc-4-pinacol borate L-phenylalanine;N-Boc-4-(pinacolyloxylboronyl)-L-phenylalanine;N-tert-butyloxycarbonyl-4-pinacolatoborono-L-phenylalanine;N-Boc-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-L-phenylalanine;N-[(1,1-Dimethylethoxy)carbonyl]-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-L-phenylalanine;L-Phenylalanine, N-[(1,1-dimethylethoxy)carbonyl]-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-;2-(tert-butoxycarbonylamino)-3-(4-(4,4,5,5-tetramethyl- 1,3,2-dioxaborolan-2-yl)phenyl)propanoic acid
CBNumber: CB72684308
Molecular Formula: C20H30BNO6
Formula Weight: 391.27
MOL File: 216439-76-8.mol

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Boc-4-pinicalborane-L-phenylalanine Property

Boiling point:: 537.2±50.0 °C(Predicted)
Density: 1.14±0.1 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: 3.86±0.10(Predicted)
Appearance: White to off-white Solid

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Synthonix

Product number: B22364
Product name: (S)-2-((tert-Butoxycarbonyl)amino)-3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)propanoicacid
Purity: 97%
Packaging: 100mg
Price: $60
Updated: 2021/12/16

ChemScene

Product number: CS-M3317
Product name: L-Phenylalanine,N-[(1,1-dimethylethoxy)carbonyl]-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-
Packaging: 250mg
Price: $61
Updated: 2021/12/16

Synthonix

Product number: B22364
Product name: (S)-2-((tert-Butoxycarbonyl)amino)-3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)propanoicacid
Purity: 97%
Packaging: 250mg
Price: $80
Updated: 2021/12/16

Activate Scientific

Product number: AS102295
Product name: N-Boc-4-(pinacolyloxylboronyl)-L-phenylalanine
Purity: 95% ee
Packaging: 250mg
Price: $95
Updated: 2021/12/16

ChemScene

Product number: CS-M3317
Product name: L-Phenylalanine,N-[(1,1-dimethylethoxy)carbonyl]-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-
Packaging: 1g
Price: $123
Updated: 2021/12/16

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Boc-4-pinicalborane-L-phenylalanine Chemical Properties,Usage,Production

Synthesis

220587-29-1

216439-76-8

119771-23-2

Synthesis of (S)-2-((tert-butoxycarbonyl)amino)-3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)propionic acid from methyl (S)-2-((tert-butoxycarbonyl)amino)-3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)propionate and ( S)-3-(4-boronic acid phenyl)-2-((tert-butoxycarbonyl)amino)propionic acid was performed in the following general steps: the above organic ester layer was stirred with an aqueous lithium hydroxide solution (23 g, dissolved in 500 mL of water) for 30 min at room temperature. The pH of the reaction mixture was adjusted to about 10 with 6N hydrochloric acid and subsequently filtered. The filter cake was washed with 200 mL of water. Acetonitrile was removed from the filtrate by distillation under reduced pressure to give an aqueous slurry (water was supplemented during distillation to a total volume of 950 mL). The slurry was filtered through a 20 micron cellulose pad and the filter cake was washed with 200 mL of water. The filtrate was washed with 500 mL of methyl tertiary butyl ether (MTBE) and then rediluted with 700 mL of MTBE. The mixture was acidified with 6N hydrochloric acid to pH about 4.5. The organic layer was washed with 500 mL of water and concentrated under reduced pressure to give the target acid compound as a brown oil (206 g, estimated purity of 95% based on NMR). The crude product can be used directly in the next step of the reaction. Alternatively, it can be purified by solvent recrystallization from MTBE/heptane mixture to give a white solid product containing a small amount of (S)-3-(4-boronic acid phenyl)-2-((tert-butoxycarbonyl)amino)propanoic acid. Mass spectral (ESI) data: MH+ = 392.2, MNH4+ = 409.2, M2H+ = 783.4, M2NH4+ = 800.4. 1H NMR (CDCl3) δ 7.95 (br s, 1H), 7.76 (d, J = 7.8 Hz, 2H), 7.21 (d, J = 7.6 Hz, 2H), 5.03 (d, J = 7.8 Hz, 1H), 4.62 (m, 1H), 3.18 (m, 2H), 1.43 (s, 9H), 1.35 (s, 12H).13C NMR (CDCl3) δ 175.8, 155.7, 139.7, 135.4, 129.2, 84.2, 80.5, 54.5, 38.3, 28.7, 25.2.

References

[1] Patent: US2009/62540, 2009, A1. Location in patent: Page/Page column 8-9
[2] Patent: US2009/88447, 2009, A1. Location in patent: Page/Page column 5-6

Boc-4-pinicalborane-L-phenylalanine Preparation Products And Raw materials

Raw materials

Preparation Products

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Boc-4-pinicalborane-L-phenylalanine Suppliers

China 78 India 1 United States 2 Global 81

ChengDu TongChuangYuan Pharmaceutical Co.Ltd

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Taizhou Tongxin Bio-Tech Co., Ltd

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Bide Pharmatech Ltd.

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View Lastest Price from Boc-4-pinicalborane-L-phenylalanine manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: (S)-2-((tert-Butoxycarbonyl)amino)-3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)propanoic acid 216439-76-8
Price: US $2.00-5.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2025-06-24

Career Henan Chemical Co

Product: Boc-4-pinicalborane-L-phenylalanine 216439-76-8
Price: US $6.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1kg, 5kg, 50kg
Release date: 2020-01-09

216439-76-8, Boc-4-pinicalborane-L-phenylalanineRelated Search:

Boc-4-pinicalborane-L-phenylalanine

(S)-2-(tert-butoxycarbonylamino)-3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)propanoic acid

L-Phenylalanine, N-[(1,1-dimethylethoxy)carbonyl]-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-

N-Boc-4-(pinacolyloxylboronyl)-L-phenylalanine

2-(tert-butoxycarbonylamino)-3-(4-(4,4,5,5-tetramethyl- 1,3,2-dioxaborolan-2-yl)phenyl)propanoic acid

N-tert-butyloxycarbonyl-4-pinacolatoborono-L-phenylalanine

N-[(1,1-Dimethylethoxy)carbonyl]-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-L-phenylalanine

216439-76-8

N-Boc-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-L-phenylalanine

Boc-4-Pinicalborane-L-Phe-OH

Boc-4-pinacol borate L-phenylalanine

(2S)-2-[(2-methylpropan-2-yl)oxycarbonylamino]-3-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]propanoic acid

(S)-2-((tert-Butoxycarbonyl)amino)-3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)propanoic acid - [B22364]

216439-76-8

C20H30BNO6