ChemicalBook > CAS DataBase List > ApiliMod (Mesylate)

ApiliMod (Mesylate)

Product Name
ApiliMod (Mesylate)
CAS No.
870087-36-8
Chemical Name
ApiliMod (Mesylate)
Synonyms
LAM-002A;Apilimodmesilate;STA5326 mesylate;AIT-101 mesylate;STA-5326 mesylate;STA 5326 mesylate;Apilimod dimesylate;ApiliMod (Mesylate);Apilimodmesylate, >98%;Dimethanesulfonic acid
CBNumber
CB72685921
Molecular Formula
C24H30N6O5S
Formula Weight
514.6
MOL File
870087-36-8.mol
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ApiliMod (Mesylate) Property

storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
form 
Powder
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Tocris
Product number
7283
Product name
Apilimoddimesylate
Purity
≥98%(HPLC)
Packaging
5
Price
$139
Updated
2021/12/16
Biosynth Carbosynth
Product number
BA177431
Product name
Apilimod mesylate NEW
Packaging
25mg
Price
$250
Updated
2021/12/16
Biosynth Carbosynth
Product number
BA177431
Product name
Apilimod mesylate NEW
Packaging
50mg
Price
$375
Updated
2021/12/16
Biosynth Carbosynth
Product number
BA177431
Product name
Apilimod mesylate NEW
Packaging
100mg
Price
$500
Updated
2021/12/16
ChemScene
Product number
CS-2342
Product name
Apilimod(mesylate)
Purity
99.40%
Packaging
100mg
Price
$520
Updated
2021/12/16
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ApiliMod (Mesylate) Chemical Properties,Usage,Production

Uses

Apilimod (STA 5326) mesylate is a potent IL-12/IL-23 inhibitor, and strongly inhibits IL-12 with IC50s of 1 nM and 2 nM, in IFN-γ/SAC-stimulated human PBMCs and SAC-treated monkey PBMCs, respectively[1]. Apilimod is a potent and highly selective PIKfyve inhibitor.

in vivo

Apilimod (10 mg/kg, p.o.) is effective not only when administered throughout the entire experiment, but also when administration is initiated on day 30 when disease is clearly measurable but not maximal. Apilimod causes a significant reduction in cell number only in the Th1 model, with an average percentage of inhibition of 51%±8% relative to the vehicle control. Apilimod treatment has no effect in the Th2 setting[1]. Apilimod (5 or 20 mg/kg, p.o.) reduces the level of IL-12 p40 in serum without altering body weight in EAU mice. Oral administration of Apilimod reduces the severity of experimental autoimmune uveoretinitis (EAU) by clinical and histopathological analysis[2].

IC 50

IL-4; IL-5; IL-8; IL-12; IL-23

storage

Store at -20°C

References

[1] Wada Y, et al. Selective abrogation of Th1 response by STA-5326, a potent IL-12/IL-23 inhibitor. Blood. 2007 Feb 1;109(3):1156-64. DOI:10.1182/blood-2006-04-019398
[2] Billich A. Drug evaluation: apilimod, an oral IL-12/IL-23 inhibitor for the treatment of autoimmune diseases and common variable immunodeficiency.IDrugs. 2007 Jan;10(1):53-9. PMID:17187316
[3] Keino H, et al. Therapeutic effect of the potent IL-12/IL-23 inhibitor STA-5326 on experimental autoimmune uveoretinitis. Arthritis Res Ther. 2008;10(5):R122. DOI:10.1186/ar2530

ApiliMod (Mesylate) Preparation Products And Raw materials

Raw materials

Preparation Products

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ApiliMod (Mesylate) Suppliers

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View Lastest Price from ApiliMod (Mesylate) manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
Apilimod mesylate 870087-36-8
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
Apilimod mesylate 870087-36-8
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-09
Career Henan Chemical Co
Product
ApiliMod (Mesylate) 870087-36-8
Price
US $1.00/KG
Min. Order
1KG
Purity
95%~99%
Supply Ability
per week 100kg
Release date
2019-09-05

870087-36-8, ApiliMod (Mesylate)Related Search:


  • STA 5326 mesylate
  • STA 5326 MESYLATE; STA5326 MESYLATE; STA-5326 MESYLATE
  • STA5326 mesylate
  • STA-5326 mesylate
  • Apilimodmesylate, >98%
  • ApiliMod (Mesylate)
  • (E)-4-(6-(2-(3-methylbenzylidene)hydrazinyl)-2-(2-(pyridin-2-yl)ethoxy)pyrimidin-4-yl)morpholine methanesulfonate
  • Apilimod dimesylate
  • Apilimodmesilate
  • (E)-4-(6-(2-(3-Methylbenzylidene)hydrazinyl)-2-(2-(pyridin-2-yl)ethoxy)pyrimidin-4-yl)morpholine dimethanesulfonate
  • 4-(6-(2-(3-Methylbenzylidene)hydrazinyl)-2-(2-(pyridin-2-yl)ethoxy)pyrimidin-4-yl)morpholine dimethanesulfonate
  • Apilimod,inhibit,Interleukin Related,STA-5326,Fab1,STA5326,STA 5326,Apilimod mesylate,Inhibitor,PIKfyve
  • Apilimod (STA-5326) mesylate
  • Benzaldehyde, 3-methyl-,[6-(4-morpholinyl)-2-[2-(2-pyridinyl)ethoxy]-4-pyrimidinyl]hydrazone,dimethanesulfonate
  • Apilimod mesylate, 10 mM in DMSO
  • AIT-101 mesylate
  • LAM-002A
  • Dimethanesulfonic acid
  • (e)-4-(6-(2-(3-methylbenzylidene)hydrazineyl)-2-(2-(pyridin-2-yl)ethoxy)pyrimidin-4-yl)morpholine dimethanesulfonate
  • 870087-36-8
  • C23H26N6O22CH4O3S
  • C25H34N6O8S2