24-Hydroxycholesterol
- Product Name
- 24-Hydroxycholesterol
- CAS No.
- 30271-38-6
- Chemical Name
- 24-Hydroxycholesterol
- Synonyms
- D4-24-Hydroxycholesterol;Cholest-5-ene-3,24-diol, (3β)-
- CBNumber
- CB72695030
- Molecular Formula
- C27H46O2
- Formula Weight
- 402.65
- MOL File
- 30271-38-6.mol
24-Hydroxycholesterol Property
- Boiling point:
- 513.1±23.0 °C(Predicted)
- Density
- 1.03±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 15.03±0.70(Predicted)
- color
- White to Off-White
- InChIKey
- IOWMKBFJCNLRTC-APZZRWHHNA-N
- SMILES
- C1C[C@]2(C)[C@H]3CC[C@]4(C)[C@H]([C@@H](C)CCC(O)C(C)C)CC[C@H]4[C@@H]3CC=C2C[C@H]1O |&1:2,4,7,9,10,21,22,27,r|
N-Bromosuccinimide Price
- Product number
- H918040
- Product name
- 24-Hydroxycholesterol
- Packaging
- 100mg
- Price
- $1455
- Updated
- 2021/12/16
- Product number
- 70600
- Product name
- 24-Hydroxycholesterol
- Packaging
- 100mg
- Price
- $2200
- Updated
- 2021/12/16
- Product number
- CS-6969
- Product name
- 24-Hydroxycholesterol
- Purity
- ≥98.0%
- Packaging
- 2mg
- Price
- $180
- Updated
- 2021/12/16
- Product number
- CS-6969
- Product name
- 24-Hydroxycholesterol
- Purity
- ≥98.0%
- Packaging
- 5mg
- Price
- $360
- Updated
- 2021/12/16
24-Hydroxycholesterol Chemical Properties,Usage,Production
Uses
24-Hydroxycholesterol is the main cholesterol elimination product of the brain and was found to be increased in serum of Alzheimer patients.
Definition
ChEBI: 24-hydroxycholesterol is an oxysterol that is cholesterol which is substituted by a hydroxy group at position 24. It is a 24-hydroxy steroid, an oxysterol and a 3beta-hydroxy-Delta(5)-steroid. It is functionally related to a cholesterol.
in vivo
Hypoxia inducible factor-1a (HIF-1α) controls the overexpression of the enzyme Cyp46a1, which generates the oxysterol 24-hydroxycholesterol in a pancreatic neuroendocrine tumor (pNET) model commonly used to study neoangiogenesis. The activation of the HIF-1α-24S-HC axis ultimately leads to the induction of the angiogenic switch through the positioning of proangiogenic neutrophils in proximity to Cyp46a1+ islets[1]. 24-hydroxycholesterol levels are increased at 2-4 months in the untreated 5XFAD mouse brain and then became similar to those in the B6SJL mouse brain[2].
IC 50
NMDA Receptor
24-Hydroxycholesterol Preparation Products And Raw materials
Raw materials
Preparation Products
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