ChemicalBook > CAS DataBase List > N-(2-(2-(2-Methoxy-4-MorpholinophenylaMino)-5-fluoropyriMidin-4-ylaMino)phenyl)MethanesulfonaMide

N-(2-(2-(2-Methoxy-4-MorpholinophenylaMino)-5-fluoropyriMidin-4-ylaMino)phenyl)MethanesulfonaMide

Product Name
N-(2-(2-(2-Methoxy-4-MorpholinophenylaMino)-5-fluoropyriMidin-4-ylaMino)phenyl)MethanesulfonaMide
CAS No.
1191911-26-8
Chemical Name
N-(2-(2-(2-Methoxy-4-MorpholinophenylaMino)-5-fluoropyriMidin-4-ylaMino)phenyl)MethanesulfonaMide
Synonyms
CZC-25146;CHEMBL2397014;LRRK2 Inhibitor II;CZC-25146 freebase;CZC-25146, 10 mM in DMSO;LRRK2 INHIBITOR II;CZC25146;CZC 25146;N-(2-(2-(2-Methoxy-4-MorpholinophenylaMino)-5-fluoropyriMidin-4-ylaMino)phenyl)MethanesulfonaMide;N-(2-((5-fluoro-2-((2-methoxy-4- morpholinophenyl)amino)pyrimidin- 4- yl)amino)phenyl)methanesulfonamide;N-[2-[[5-Fluoro-2-[[2-methoxy-4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]amino]phenyl]methanesulfonamide;CZC-25146/N-(2-(2-(2-Methoxy-4-MorpholinophenylaMino)-5-fluoropyriMidin-4-ylaMino)phenyl)MethanesulfonaMide
CBNumber
CB72695999
Molecular Formula
C22H25FN6O4S
Formula Weight
488.54
MOL File
1191911-26-8.mol
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N-(2-(2-(2-Methoxy-4-MorpholinophenylaMino)-5-fluoropyriMidin-4-ylaMino)phenyl)MethanesulfonaMide Property

Boiling point:
697.4±65.0 °C(Predicted)
Density 
1.436±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
solubility 
≥24.45 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O
form 
solid
pka
8.48±0.10(Predicted)
color 
Pale purple to purple
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
22931
Product name
CZC-25146
Purity
≥98%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
22931
Product name
CZC-25146
Purity
≥98%
Packaging
5mg
Price
$116
Updated
2024/03/01
Cayman Chemical
Product number
22931
Product name
CZC-25146
Purity
≥98%
Packaging
10mg
Price
$199
Updated
2024/03/01
Cayman Chemical
Product number
22931
Product name
CZC-25146
Purity
≥98%
Packaging
25mg
Price
$456
Updated
2024/03/01
Tocris
Product number
6071
Product name
CZC25146
Purity
≥98%(HPLC)
Packaging
10
Price
$235
Updated
2021/12/16
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N-(2-(2-(2-Methoxy-4-MorpholinophenylaMino)-5-fluoropyriMidin-4-ylaMino)phenyl)MethanesulfonaMide Chemical Properties,Usage,Production

Description

CZC-25146 is a potent inhibitor of leucine-rich repeat kinase 2 (LRRK2; IC50 = 4.76 nM for the human recombinant kinase). It also inhibits LRRK2G2019S, a mutant linked to neurotoxicity and Parkinson’s disease, with an IC50 value of 6.87 nM. CZC-25146 is selective for LRRK2 over a panel of kinases in HeLa cell lysates, Jurkat/Ramos mixed cell lysates, as well as whole mouse brain extracts (IC50s = >2 μM). It reduces LRRK2G2019S-induced cell injury in rat primary cortical neurons.

Uses

CZC-25146 is a compound that acts as an inhibitor of LRRK2, a factor in the expression of Parkinsons’s disease, and is ATP-competitive.

storage

Store at -20°C

References

[1] ramsden n, perrin j, ren z, et al. chemoproteomics-based design of potent lrrk2-selective lead compounds that attenuate parkinson’s disease-related toxicity in human neurons. acs chemical biology, 2011, 6(10): 1021-1028.
[2] troxler t, greenidge p, zimmermann k, et al. discovery of novel indolinone-based, potent, selective and brain penetrant inhibitors of lrrk2. bioorganic & medicinal chemistry letters, 2013, 23(14): 4085-4090.

N-(2-(2-(2-Methoxy-4-MorpholinophenylaMino)-5-fluoropyriMidin-4-ylaMino)phenyl)MethanesulfonaMide Preparation Products And Raw materials

Raw materials

Preparation Products

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N-(2-(2-(2-Methoxy-4-MorpholinophenylaMino)-5-fluoropyriMidin-4-ylaMino)phenyl)MethanesulfonaMide Suppliers

Canada 1 China 61 India 2 United Kingdom 1 United States 13 Global 78
Toronto Research Chemicals
Tel
--
Fax
--
Email
info@trc-canada.com
Country
Canada
ProdList
6038
Advantage
71
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View Lastest Price from N-(2-(2-(2-Methoxy-4-MorpholinophenylaMino)-5-fluoropyriMidin-4-ylaMino)phenyl)MethanesulfonaMide manufacturers

Career Henan Chemical Co
Product
N-(2-(2-(2-Methoxy-4-MorpholinophenylaMino)-5-fluoropyriMidin-4-ylaMino)phenyl)MethanesulfonaMide 1191911-26-8
Price
US $1.00/g
Min. Order
1g
Purity
99%
Supply Ability
200kg
Release date
2019-12-26

1191911-26-8, N-(2-(2-(2-Methoxy-4-MorpholinophenylaMino)-5-fluoropyriMidin-4-ylaMino)phenyl)MethanesulfonaMideRelated Search:


  • CZC-25146
  • N-[2-[[5-Fluoro-2-[[2-methoxy-4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]amino]phenyl]methanesulfonamide
  • N-(2-(2-(2-Methoxy-4-MorpholinophenylaMino)-5-fluoropyriMidin-4-ylaMino)phenyl)MethanesulfonaMide
  • N-(2-((5-fluoro-2-((2-methoxy-4- morpholinophenyl)amino)pyrimidin- 4- yl)amino)phenyl)methanesulfonamide
  • LRRK2 Inhibitor II
  • LRRK2 INHIBITOR II;CZC25146;CZC 25146
  • CHEMBL2397014
  • Methanesulfonamide, N-[2-[[5-fluoro-2-[[2-methoxy-4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]amino]phenyl]-
  • CZC-25146/N-(2-(2-(2-Methoxy-4-MorpholinophenylaMino)-5-fluoropyriMidin-4-ylaMino)phenyl)MethanesulfonaMide
  • CZC-25146 freebase
  • Leucine-rich repeat kinase 2,Parkinson's disease,Inhibitor,LRRK2,CZC 25146,liver diseases,CZC25146,inhibit,neurons,CZC-25146,inflammatory,LRRK2 G2019S
  • CZC-25146, 10 mM in DMSO
  • 1191911-26-8
  • C22H25FN6O4S
  • Amines, Aromatics, Heterocycles, Inhibitors, Pharmaceuticals, Intermediates & Fine Chemicals
  • API