PlatensiMycin
- Product Name
- PlatensiMycin
- CAS No.
- 835876-32-9
- Chemical Name
- PlatensiMycin
- Synonyms
- laminomycin;PlatensiMycin;Platensimycin, Streptomyces sp. - CAS 835876-32-9 - Calbiochem;Benzoic acid, 3-[[3-[(1S,3S,4S,5aS,9S,9aR)-1,4,5,8,9,9a-hexahydro-3,9-dimethyl-8-oxo-3H-1,4:3,5a-dimethano-2-benzoxepin-9-yl]-1-oxopropyl]amino]-2,4-dihydroxy-
- CBNumber
- CB72703755
- Molecular Formula
- C24H27NO7
- Formula Weight
- 441.474
- MOL File
- 835876-32-9.mol
PlatensiMycin Property
- Melting point:
- 220-222 °C(Solv: nitromethane (75-52-5))
- Boiling point:
- 683.1±55.0 °C(Predicted)
- Density
- 1.47±0.1 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- DMSO: soluble1mg/mL, clear, colorless
- form
- Tan solid
- pka
- 2.14±0.13(Predicted)
- color
- white to beige
N-Bromosuccinimide Price
- Product number
- 528244
- Product name
- Platensimycin, Streptomyces sp. - CAS 835876-32-9 - Calbiochem
- Purity
- A cell-permeable Streptomyces-derived antibiotic that exhibits broad-spectrum Gram-positive antibacterial activity by selectively targeting the elongation condensing enzyme FabF.
- Packaging
- 250μg
- Price
- $405
- Updated
- 2022/05/15
- Product number
- 15507
- Product name
- Platensimycin
- Purity
- ≥95%
- Packaging
- 250μg
- Price
- $347
- Updated
- 2024/03/01
- Product number
- 15507
- Product name
- Platensimycin
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $1249
- Updated
- 2024/03/01
- Product number
- P578205
- Product name
- Platensimycin
- Packaging
- 250μg
- Price
- $350
- Updated
- 2021/12/16
- Product number
- P578205
- Product name
- Platensimycin
- Packaging
- 500μg
- Price
- $560
- Updated
- 2021/12/16
PlatensiMycin Chemical Properties,Usage,Production
Uses
Platensimycin is a novel, broad spectrum, Gram-positive antibiotic produced by strains of Streptomyces platensis. Its discovery was heralded by high profile publication and commentary in the scientific and lay press. Platensimycin was discovered by a target-based, whole-cell screening strategy using an antisense differential sensitivity assay, based on the inhibition of fatty acid synthesis. Platensimycin inhibits bacterial growth by selectively inhibiting the elongation enzyme, b-ketoacyl acyl carrier protein synthase (FabF) of the fatty acid synthesis pathway.
Uses
Platensimycin is a broad spectrum gram-positive antibiotic.
Definition
ChEBI: A monocarboxylic acid amide obtained by the formal condensation of the amino group of 3-amino-2,4-dihydroxybenzoic acid with the carboxy group of the oxatetracyclic cage component. It is an antibiotic isolated from Streptomyces platensis a d exhibits inhibitory activity against fatty acid synthase.
Enzyme inhibitor
This thiol-reactive Streptomyces platensis-derived antibiotic (FW = 438.50 g/mol; CAS 835876-32-9), also named 3-[[3-[(1R,3R,4R,5aR,9R,9aS)- 1,4,5,8,9,9a-hexahydro-3,9-dimethyl-8-oxo-3H-1,4:3,5a-dimethano-2- benzoxepin-9-yl]-1-oxopropyl]amino]-2,4-dihydroxybenzoic acid, inhibits Staphylococcus aureus b-ketoacyl-[acyl-carrier-protein] synthase II, or FabF (IC50 = 290 nM). This enzyme, which allows bacteria to produce the fatty acids needed for making cell membranes, is thus a uniquely druggable prokaryotic target. Platensimycin has potent, broad-spectrum Gram-positive activity in vitro and exhibits no cross-resistance to other key antibiotic-resistant bacteria including Methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-intermediate S. aureus, vancomycin-resistant Enterococci, as well as linezolid-resistant and macrolide-resistant pathogens. Platencin is a more potent analogue of Platensimycin. While effective in vivo when continuously administered, its efficacy is reduced when administered by more conventional means. Mechanism of Action: The Cys163 within the FabF active site is activated through the dipole moment of helix N-a-3, lowering its pKa, also increasing its nucleophilicity by the stabilizing effects of FabF’s catalytically required oxyanion hole. Interestingly, the crystal structure complex with platensimycin employed a C163Q mutant which gave a 50-fold increase in apparent binding.
PlatensiMycin Preparation Products And Raw materials
Raw materials
Preparation Products
PlatensiMycin Suppliers
- Tel
- 86-(0)29-85992781 17792393971
- info@lynnchem.com
- Country
- China
- ProdList
- 4587
- Advantage
- 58
- Tel
- 400-9205774
- sales@glpbio.cn
- Country
- China
- ProdList
- 6777
- Advantage
- 58
- Tel
- +86-400-002-6226 +86-13028896684;
- sales@rrkchem.com
- Country
- China
- ProdList
- 57423
- Advantage
- 58
- Tel
- 18818260767
- Fax
- QQ 3610331285
- sales@chemegen.com
- Country
- China
- ProdList
- 11218
- Advantage
- 58
- Tel
- 400-820-6829
- sales@mitachieve.com
- Country
- China
- ProdList
- 8860
- Advantage
- 58
- Tel
- 021-69568360 18916172912
- order@med-bio.cn
- Country
- China
- ProdList
- 8140
- Advantage
- 58
- Tel
- 021-58432009 400-005-6266
- Fax
- 021-58436166
- marketing@energy-chemical.com
- Country
- China
- ProdList
- 44918
- Advantage
- 58
- Tel
- 4008200310
- marketing@tsbiochem.com
- Country
- China
- ProdList
- 24644
- Advantage
- 58
- Tel
- 021-58000709 15900491054
- info@scrbio.com
- Country
- China
- ProdList
- 9501
- Advantage
- 58
- Tel
- 021-65675885 18964387627
- customer_service@efebio.com
- Country
- China
- ProdList
- 11974
- Advantage
- 58
- Tel
- 025-85560043 15850508050
- Fax
- 025-85563444
- cindy.huang@synzest.com
- Country
- China
- ProdList
- 12000
- Advantage
- 58
- Tel
- 028-81700200 13308200041
- 2851167782@qq.com
- Country
- China
- ProdList
- 11183
- Advantage
- 58
- Tel
- 15317051735
- zhaojing@wytsci.com
- Country
- China
- ProdList
- 9199
- Advantage
- 58
- Tel
- +8617709210191
- Jerry@xhobio.com
- Country
- China
- ProdList
- 882
- Advantage
- 58
- Tel
- +86-18791163155 +86-13119157289
- 13119157289@163.com
- Country
- China
- ProdList
- 3558
- Advantage
- 58
- Tel
- +86-057181025280; +8617767106207
- Fax
- 0571-85806285
- sales@molcore.com
- Country
- China
- ProdList
- 49734
- Advantage
- 58
- Tel
- --
- Fax
- --
- info@neobioscience.com
- Country
- CHINA
- ProdList
- 6681
- Advantage
- 58
- Tel
- --
- Fax
- --
- chenjw@absin.cn
- Country
- CHINA
- ProdList
- 6705
- Advantage
- 58
- Tel
- --
- Fax
- --
- info@zzsrm.com
- Country
- CHINA
- ProdList
- 6650
- Advantage
- 58