Methyl (S)-4,4-difluoropyrrolidine-2-carboxylate hydrochloride

Product Name: Methyl (S)-4,4-difluoropyrrolidine-2-carboxylate hydrochloride
CAS No.: 156046-05-8
Chemical Name: Methyl (S)-4,4-difluoropyrrolidine-2-carboxylate hydrochloride
Synonyms: HCl*Dfp-OMe;(S)-methyl 4,4-difluoropyrrolidine-2-carboxylate HCl;(2S)-4,4-difluoro-L-proline methyl ester hydrochloride;L-Proline, 4,4-difluoro-, methyl ester, hydrochloride (1:1);Methyl (S)-4,4-difluoropyrrolidine-2-carboxylate hydrochloride;(S)-Methyl 4,4-difluoropyrrolidine-2-carboxylate hydrochloride;methyl (2S)-4,4-difluoropyrrolidine-2-carboxylate hydrochloride
CBNumber: CB72704712
Molecular Formula: C6H10ClF2NO2
Formula Weight: 201.5989064
MOL File: 156046-05-8.mol

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Methyl (S)-4,4-difluoropyrrolidine-2-carboxylate hydrochloride Property

storage temp.: Inert atmosphere,Room Temperature
Appearance: White to off-white Solid
optical activity: -10.9° (C=0.01 g/ml, H2O)

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Safety

HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Apolloscientific

Product number: PC201152
Product name: (S)-Methyl4,4-difluoropyrrolidine-2-carboxylatehydrochloride
Purity: 95+%
Packaging: 250mg
Price: $85
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H58-7-S0
Product name: Methyl (2S)-4,4-difluoropyrrolidine-2-carboxylate hydrochloride
Purity: 97.0%
Packaging: 250mg
Price: $190
Updated: 2021/12/16

Apolloscientific

Product number: PC201152
Product name: (S)-Methyl4,4-difluoropyrrolidine-2-carboxylatehydrochloride
Purity: 95+%
Packaging: 1g
Price: $212
Updated: 2021/12/16

Activate Scientific

Product number: AS56468-B-2S
Product name: Methyl (S)-4,4-difluoropyrrolidine-2-carboxylate HCl
Purity: 97+% ee
Packaging: 1g
Price: $247
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H58-7-S0
Product name: Methyl (2S)-4,4-difluoropyrrolidine-2-carboxylate hydrochloride
Purity: 97.0%
Packaging: 1g
Price: $490
Updated: 2021/12/16

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Methyl (S)-4,4-difluoropyrrolidine-2-carboxylate hydrochloride Chemical Properties,Usage,Production

Synthesis

203866-17-5

156046-05-8

General procedure for the synthesis of (S)-4,4-difluoropyrrolidine-2-carboxylic acid methyl ester hydrochloride from N-BOC-4,4-difluoro-L-proline methyl ester: N-BOC-4,4-difluoro-L-proline methyl ester (3 g, 11.3 mmol) was mixed with EtOAc solution (15 mL) of 4 M HCl and the reaction was stirred at room temperature for 4 hours. After completion of the reaction, the mixture was concentrated in vacuum to afford methyl (S)-4,4-difluoropyrrolidine-2-carboxylate hydrochloride (2.27 g, 100% yield) as a white solid. The structure of the compound was confirmed by the following spectral data: MS-ESI: m/z 166.14 [M + H]+; 1H NMR (400 MHz, CDCl3): δ 4.70-4.69 (m, 1H), 3.75-3.87 (m, 2H), 3.71 (s, 3H), 2.91-3.00 (m, 1H), 2.70-2.81 (m, 1H).

References

[1] Patent: EP2730572, 2015, B1. Location in patent: Paragraph 0416; 0421

Methyl (S)-4,4-difluoropyrrolidine-2-carboxylate hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Methyl (S)-4,4-difluoropyrrolidine-2-carboxylate hydrochloride Suppliers

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156046-05-8, Methyl (S)-4,4-difluoropyrrolidine-2-carboxylate hydrochlorideRelated Search:

Methyl (S)-4,4-difluoropyrrolidine-2-carboxylate hydrochloride

methyl (2S)-4,4-difluoropyrrolidine-2-carboxylate hydrochloride

(S)-Methyl 4,4-difluoropyrrolidine-2-carboxylate hydrochloride

(S)-methyl 4,4-difluoropyrrolidine-2-carboxylate HCl

L-Proline, 4,4-difluoro-, methyl ester, hydrochloride (1:1)

HCl*Dfp-OMe

(2S)-4,4-difluoro-L-proline methyl ester hydrochloride

156046-05-8

C6H10ClF2NO2