2-ThiophenecarboxaMide, 5-chloro-N-Methyl-

Product Name: 2-ThiophenecarboxaMide, 5-chloro-N-Methyl-
CAS No.: 97799-98-9
Chemical Name: 2-ThiophenecarboxaMide, 5-chloro-N-Methyl-
Synonyms: Rivaroxaban K;Rivaroxaban impurity P2-S;Rivaroxaban CMTCA Impurity;5-Chloro-N-methylthiophene-2-carboxamide;5-chloro-N-methyl-2-thiophenecarboxamide;2-Thiophenecarboxamide, 5-chloro-N-methyl-;5-chloro-2-thiophenecarboxylic acid N-methylamide;Rivaroxaban Impurity E/ Rivaroxaban CMTCA Impurity;Rivaroxaban impurity N: 5-chlorothiophene-2-carboxamide;Imp. D:5-Chloro-2-Thiophenecarboxylic Acid N-Methylamide
CBNumber: CB72707364
Molecular Formula: C6H6ClNOS
Formula Weight: 175.64
MOL File: 97799-98-9.mol

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2-ThiophenecarboxaMide, 5-chloro-N-Methyl- Property

Melting point:: 164-166°C
storage temp.: Refrigerator
solubility: Chloroform (Slightly), Methanol (Slightly)
form: Solid
color: White to Off-White

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: C373840
Product name: 5-Chloro-N-methylthiophene-2-carboxamide
Packaging: 1g
Price: $150
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0135360
Product name: 5-CHLORO-N-METHYLTHIOPHENE-2-CARBOXAMIDE
Purity: 95.00%
Packaging: 5MG
Price: $500.1
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 91647
Product name: 5-Chloro-N-methylthiophene-2-carboxamide
Packaging: 10g
Price: $1600
Updated: 2021/12/16

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2-ThiophenecarboxaMide, 5-chloro-N-Methyl- Chemical Properties,Usage,Production

Uses

5-Chloro-N-methylthiophene-2-carboxamide is an impurity of Rivaroxaban (R538000), which is a novel antithrombotic agent. A highly potent and selective, direct FXa inhibitor.

Synthesis

Step add 5-chlorothiophene-2-carboxylic acid, dichloromethane, dichlorosulfoxide dropwise at 0 , dropwise addition, room temperature stirring for 4 hours;

Step dropwise addition of aqueous solution with a mass concentration of 40% of methylamine at 0 , dropwise addition is completed, stirring at room temperature for 18 hours;

Step after the extraction of filtration, the cake is dried at 55 , the solid is 5-chlorothiophene-2-carboxymethylamine;

5-chlorothiophene-2-carboxylic acid, dichloromethane, dichlorosulfoxide, 40% methylamine. The solid is 5-chlorothiophene-2-carboxamide;

5-chlorothiophene-2-carboxylic acid, dichloromethane, dichlorosulfoxide, 40% methylamine aqueous solution of the addition of 20 g, 500 ml, 49.52 g, 107.73 g;

5-chlorothiophene-2-carboxamide is 10 g, the yield of 41.03%, purity of 99.80%.

2-ThiophenecarboxaMide, 5-chloro-N-Methyl- Preparation Products And Raw materials

Raw materials

Preparation Products

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2-ThiophenecarboxaMide, 5-chloro-N-Methyl- Suppliers

China 71 India 4 United States 2 Global 77

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97799-98-9, 2-ThiophenecarboxaMide, 5-chloro-N-Methyl-Related Search:

Rivaroxaban Impurity 88 (S)-methyl((2-oxo-3-(4-(3-oxomorpholino)phenyl)oxazolidin-5-yl) methyl)carbamate (S)-5-chloro-N-(3-(5-chlorothiophene-2-carboxamido)-2- hydroxypropyl)-N-(4-(3-oxomorpholino)phenyl)thiophene-2- carboxamide Rivaroxaban Impurity 55 (S)-2-(3-chloro-2-hydroxypropyl)isoindoline-1,3-dione Rivaroxaban Impurity 61 Rivaroxaban Impurity 12 4,5-dichloro Rivaroxaban AcetaMide, N-[[(5S)-2-oxo-3-[4-(3-oxo-4-Morpholinyl)phenyl]-5-oxazolidinyl]Methyl]- 2-ThiophenecarboxaMide, N-[[(5S)-2-oxo-3-[4-(3-oxo-4-Morpholinyl)phenyl]-5-oxazolidinyl]Methyl]- Rivaroxaban Impurity 79 (R)-5-chloro-N-(4-(3-oxomorpholino)phenyl)-N- ((2-oxooxazolidin-5-yl)methyl)thiophene-2-carboxamide Rivaroxaban Impurity 43 2-ThiophenecarboxaMide, 5-chloro-N,N-diMethyl- Rivaroxaban iMpurity ethyl 4-(3-oxoMorpholino) phenylcarbaMate 2-ThiophenecarboxaMide, 5-chloro-N-[(2S)-2-hydroxy-3-[[4-(3-oxo-4-Morpholinyl)phenyl]aMino]propyl]- Rivaroxaban Impurity 41

5-chloro-2-thiophenecarboxylic acid N-methylamide

2-Thiophenecarboxamide, 5-chloro-N-methyl-

Rivaroxaban K

5-Chloro-N-methylthiophene-2-carboxamide

Rivaroxaban Impurity 18/5-Chloro-2-Thiophenecarboxylic Acid N-Methylamide

Rivaroxaban impurity N: 5-chlorothiophene-2-carboxamide

2-ThiophenecarboxaMide, 5-chloro-N-Methyl- ExperiMental Properties

Rivaroxaban Related Compound (5-Chloro-2-Thiophenecarboxylic Acid N-Methylamide)

Rivaroxaban CMTCA Impurity

Imp. D:5-Chloro-2-Thiophenecarboxylic Acid N-Methylamide

Rivaroxaban impurity P2-S

2-ThiophenecarboxaMide, 5-chloro-N-Methyl- ISO 9001：2015 REACH

5-Chloro-N-methylthiophene-2-carboxamide (Rivaroxaban Impurity)

Rivaroxaban Impurity E/ Rivaroxaban CMTCA Impurity

5-chloro-N-methyl-2-thiophenecarboxamide

97799-98-9