4-Chloro-2-Methoxy-3-nitropyridine
- Product Name
- 4-Chloro-2-Methoxy-3-nitropyridine
- CAS No.
- 934180-48-0
- Chemical Name
- 4-Chloro-2-Methoxy-3-nitropyridine
- Synonyms
- 4-Chloro-2-Methoxy-3-nitropyridine;Pyridine, 4-chloro-2-methoxy-3-nitro-
- CBNumber
- CB72707647
- Molecular Formula
- C6H5ClN2O3
- Formula Weight
- 188.57
- MOL File
- 934180-48-0.mol
4-Chloro-2-Methoxy-3-nitropyridine Property
- Boiling point:
- 276.0±35.0 °C(Predicted)
- Density
- 1.445±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 1.04±0.10(Predicted)
- form
- solid
- color
- Off-white
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C632228
- Product name
- 4-Chloro-2-methoxy-3-nitropyridine
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 4H54-5-3P
- Product name
- 4-Chloro-2-methoxy-3-nitropyridine
- Purity
- 97%
- Packaging
- 250mg
- Price
- $258
- Updated
- 2021/12/16
- Product number
- 5828DN
- Product name
- 4-Chloro-2-methoxy-3-nitropyridine
- Packaging
- 1g
- Price
- $745
- Updated
- 2021/12/16
- Product number
- AA10-1309
- Product name
- 4-Chloro-2-methoxy-3-nitro-pyridine
- Purity
- 95%
- Packaging
- 1g
- Price
- $475
- Updated
- 2021/12/16
- Product number
- CD11010004
- Product name
- 4-Chloro-2-methoxy-3-nitropyridine
- Purity
- 95+%
- Packaging
- 1g
- Price
- $503
- Updated
- 2021/12/16
4-Chloro-2-Methoxy-3-nitropyridine Chemical Properties,Usage,Production
Synthesis
165547-79-5
74-88-4
934180-48-0
The general procedure for the synthesis of 4-chloro-2-methoxy-3-nitropyridine from 2-hydroxy-3-nitro-4-chloropyridine and iodomethane was as follows: iodomethane (2.06 mL, 32.99 mmol) was slowly added to a suspension of 4-chloro-2-hydroxy-3-nitropyridine (2.87 g, 16.49 mmol) (for preparation, see Bioorg. Med. . chem. lett., 2003, 13, 125). The reaction mixture was heated with stirring at 85°C for 3.5 hours. Subsequently, a solution of sodium carbonate (16.49 mmol) in toluene (100 mL) was added to the reaction system and heating was continued. After the reaction mixture was cooled to room temperature, it was filtered through a diatomaceous earth pad and the solids were washed with toluene. The filtrate and washings were combined and concentrated under reduced pressure to remove the solvent. The crude product was purified by silica gel column chromatography using ethyl acetate:heptane (1:9, v/v) as eluent. The target fraction was collected and concentrated under reduced pressure to give the white solid product 4-chloro-2-methoxy-3-nitropyridine (1.99 g, 64% yield). Product characterization data: MS (ESI) m/z: 189/191 ([M + H]+).
References
[1] Patent: WO2007/39563, 2007, A1. Location in patent: Page/Page column 24
[2] Patent: US2007/112019, 2007, A1. Location in patent: Page/Page column 12/2
4-Chloro-2-Methoxy-3-nitropyridine Preparation Products And Raw materials
Raw materials
Preparation Products
4-Chloro-2-Methoxy-3-nitropyridine Suppliers
- Tel
- 0531-81313138 13066006660
- Fax
- QQ: 3366077777
- chibapharm@foxmail.com
- Country
- China
- ProdList
- 3978
- Advantage
- 55
- Tel
- 571-89925085
- Fax
- 0086-571-89925065
- sales@amadischem.com
- Country
- China
- ProdList
- 131957
- Advantage
- 58
- Tel
- 025-66061636 18013972705
- Fax
- (3)02557626880
- qqyang@aikonchem.com
- Country
- China
- ProdList
- 15814
- Advantage
- 58
- Tel
- 4009004166/18616739031 18616739031
- 3007523370@qq.com
- Country
- China
- ProdList
- 52687
- Advantage
- 58
- Tel
- 18032763683 13102890206; 18032763683
- Fax
- QQ：442112647
- 442112647@qq.com
- Country
- China
- ProdList
- 300
- Advantage
- 58
- Tel
- 15151934985
- sales@yingsapharm.com
- Country
- China
- ProdList
- 5185
- Advantage
- 58
- Tel
- 15195022192
- 279776773@qq.com
- Country
- China
- ProdList
- 1996
- Advantage
- 58
- Tel
- 021-58461859 15821823057
- service@aiviche.com
- Country
- China
- ProdList
- 49312
- Advantage
- 58
- Tel
- +8613580539051
- joe@yuhengpharm.com
- Country
- CHINA
- ProdList
- 21142
- Advantage
- 58
- Tel
- 025-85560043 13675144456
- Fax
- 025-85563444
- sean.lv@synzest.com
- Country
- China
- ProdList
- 11438
- Advantage
- 58