Methyl 2-(3-broMophenyl)-2-Methylpropanoate
- Product Name
- Methyl 2-(3-broMophenyl)-2-Methylpropanoate
- CAS No.
- 251458-15-8
- Chemical Name
- Methyl 2-(3-broMophenyl)-2-Methylpropanoate
- Synonyms
- 2-(3-bromophenyl) -2-methylpropionate;Methyl 2-(3-broMophenyl)-2-Methylpropanoate;Benzeneacetic acid, 3-bromo-α,α-dimethyl-, methyl ester;2-(3-Bromo-phenyl)-2-methyl-propionic acid methyl ester;3-Bromo-Alpha,Alpha-Dimethyl-Benzeneacetic Acid Methyl Ester
- CBNumber
- CB72710171
- Molecular Formula
- C11H13BrO2
- Formula Weight
- 257.12
- MOL File
- 251458-15-8.mol
Methyl 2-(3-broMophenyl)-2-Methylpropanoate Property
- storage temp.
- Sealed in dry,Room Temperature
- Appearance
- Colorless to light yellow Liquid
- InChI
- InChI=1S/C11H13BrO2/c1-11(2,10(13)14-3)8-5-4-6-9(12)7-8/h4-7H,1-3H3
- InChIKey
- ZTBCOZQPDZZCJO-UHFFFAOYSA-N
- SMILES
- C(OC)(=O)C(C1=CC=CC(Br)=C1)(C)C
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 6909AJ
- Product name
- Methyl2-(3-bromophenyl)-2-methylpropanoate
- Packaging
- 1g
- Price
- $131
- Updated
- 2021/12/16
- Product number
- BB20-6659
- Product name
- 2-(3-Bromo-phenyl)-2-methyl-propionicacidmethylester
- Purity
- 95%
- Packaging
- 1g
- Price
- $150
- Updated
- 2021/12/16
- Product number
- CM251705
- Product name
- Methyl2-(3-bromophenyl)-2-methylpropanoate
- Purity
- 95%
- Packaging
- 5g
- Price
- $224
- Updated
- 2021/12/16
- Product number
- CD12091586
- Product name
- Methyl2-(3-bromophenyl)-2-methylpropanoate
- Purity
- 95+%
- Packaging
- 5g
- Price
- $238
- Updated
- 2021/12/16
- Product number
- 251458158
- Product name
- Methyl2-(3-bromophenyl)-2-methylpropanoate
- Packaging
- 5g
- Price
- $254.4
- Updated
- 2021/12/16
Methyl 2-(3-broMophenyl)-2-Methylpropanoate Chemical Properties,Usage,Production
Synthesis
150529-73-0
74-88-4
251458-15-8
Sodium hydride (60% oil solution, 10.4 g, 436 mmol) was added to tetrahydrofuran (400 mL) under argon protection, stirred and heated to 50 °C. Subsequently, methyl 2-(3-bromophenyl)acetate (20 g, 87.3 mmol) was added. The reaction mixture was added dropwise over 30 minutes and continued to be heated at 50 °C for 90 minutes. After completion of the reaction, the temperature was lowered to below 40 °C and iodomethane (13 mL, 209 mmol) was added over 10 min. The resulting suspension was stirred overnight at room temperature. At the end of the reaction, water (300 mL) was carefully added and the reaction mixture was concentrated. The residue was partitioned between ether (400 mL) and water. The aqueous layer was extracted with ether (400 mL) and the combined organic layers were dried over anhydrous sodium sulfate and concentrated to give the crude product. The crude product was purified by column chromatography using a gradient elution with a heptane solution of 0 to 20% ethyl acetate to afford methyl 2-(3-bromophenyl)-2-methylpropionate (14.96 g, 58 mmol, 67% yield).1H NMR (400 MHz, CDCl3): δ 7.47 (t, 1H), 7.37 (dt, 1H), 7.24 (dt. 1H), 7.18 (t, 1H), 3.65 (s, 3H), 1.55 (s, 6H).
References
[1] Patent: US2010/197591, 2010, A1. Location in patent: Page/Page column 15-16
[2] Journal of Medicinal Chemistry, 2008, vol. 51, # 3, p. 392 - 395
[3] Patent: US2005/80111, 2005, A1
[4] Patent: WO2014/201073, 2014, A1. Location in patent: Paragraph 00218
[5] Patent: WO2004/48374, 2004, A1. Location in patent: Page 47
Methyl 2-(3-broMophenyl)-2-Methylpropanoate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Methyl 2-(3-broMophenyl)-2-Methylpropanoate manufacturers
- Product
- Methyl 2-(3-broMophenyl)-2-Methylpropanoate 251458-15-8
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 100kg
- Release date
- 2020-01-14