ML 254

Product Name: ML 254
CAS No.: 1428630-86-7
Chemical Name: ML 254
Synonyms: ML 254;5-((3-fluorophenyl)ethynyl)-N-(3-methyloxetan-3-yl)picolinamide;5-[2-(3-fluorophenyl)ethynyl]-N-(3-methyloxetan-3-yl)pyridine-2-carboxamide;2-Pyridinecarboxamide, 5-[2-(3-fluorophenyl)ethynyl]-N-(3-methyl-3-oxetanyl)-;ML 254,inhibit,ML254,ML-254,Inhibitor,Metabotropic glutamate receptors,mGluR,Schizophrenia
CBNumber: CB72716289
Molecular Formula: C18H15FN2O2
Formula Weight: 310.32
MOL File: 1428630-86-7.mol

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ML 254 Property

form: Solid
color: Off-white to light yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

DC Chemicals

Product number: DC43016
Product name: ML254
Purity: >98%
Packaging: 100mg
Price: $850
Updated: 2021/12/16

DC Chemicals

Product number: DC43016
Product name: ML254
Purity: >98%
Packaging: 250mg
Price: $1500
Updated: 2021/12/16

DC Chemicals

Product number: DC43016
Product name: ML254
Purity: >98%
Packaging: 1g
Price: $3000
Updated: 2021/12/16

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ML 254 Chemical Properties,Usage,Production

Description

ML-254, also known as VU0430644; is Positive Allosteric Modulators (PAMs) of mGlu5 with Competitive MPEP-Site Interaction. ML254 is highly selective for mGlu5 versus other mGlu receptors, has a clean ancillary Ricerca profile, and suitable dystrophia myotonica protein kinase (DMPK) properties for systemic dosing in rodents. Preliminary experiments at a single dose in an in vivo model of psychosis using ML254 demonstrates a robust reversal of amphetamine induced hyperlocomotion. ML254 will serve as a significant pure-PAM tool compound for the field with potential for studies within in vivo paradigms. Structure activity relationship (SAR) and characterization of ML254 are described.

ML 254 Preparation Products And Raw materials

Raw materials

Preparation Products

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ML 254 Suppliers

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1428630-86-7, ML 254Related Search:

ML 254

5-[2-(3-fluorophenyl)ethynyl]-N-(3-methyloxetan-3-yl)pyridine-2-carboxamide

5-((3-fluorophenyl)ethynyl)-N-(3-methyloxetan-3-yl)picolinamide

2-Pyridinecarboxamide, 5-[2-(3-fluorophenyl)ethynyl]-N-(3-methyl-3-oxetanyl)-

ML 254,inhibit,ML254,ML-254,Inhibitor,Metabotropic glutamate receptors,mGluR,Schizophrenia

1428630-86-7