4-(2-fluoro-4-nitrophenoxy)quinolin-7-ol
- Product Name
- 4-(2-fluoro-4-nitrophenoxy)quinolin-7-ol
- CAS No.
- 1394820-98-4
- Chemical Name
- 4-(2-fluoro-4-nitrophenoxy)quinolin-7-ol
- Synonyms
- 112685;4-(2-fluoro-4-nitrophenoxy)quinolin-7-ol;7-Quinolinol, 4-(2-fluoro-4-nitrophenoxy)-;7-Hydroxy-4-(2-fluoro-4-nitrophenoxy)quinoline;4-(2-fluoro-4-nitrophenoxy)quinolin-7-ol hydrochloride
- CBNumber
- CB72718344
- Molecular Formula
- C15H9FN2O4
- Formula Weight
- 300.24
- MOL File
- 1394820-98-4.mol
4-(2-fluoro-4-nitrophenoxy)quinolin-7-ol Property
- Boiling point:
- 467.4±45.0 °C(Predicted)
- Density
- 1.487±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 8.46±0.40(Predicted)
- InChI
- InChI=1S/C15H9FN2O4/c16-12-7-9(18(20)21)1-4-15(12)22-14-5-6-17-13-8-10(19)2-3-11(13)14/h1-8,19H
- InChIKey
- ORSCRIJOVRKFEO-UHFFFAOYSA-N
- SMILES
- N1C2C(=CC=C(O)C=2)C(OC2=CC=C([N+]([O-])=O)C=C2F)=CC=1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 5401EM
- Product name
- 4-(2-Fluoro-4-nitrophenoxy)quinolin-7-ol
- Packaging
- 1g
- Price
- $146
- Updated
- 2021/12/16
- Product number
- 121002
- Product name
- 4-(2-Fluoro-4-nitrophenoxy)quinolin-7-ol
- Purity
- 97%
- Packaging
- 250mg
- Price
- $2070
- Updated
- 2021/12/16
- Product number
- 121002
- Product name
- 4-(2-Fluoro-4-nitrophenoxy)quinolin-7-ol
- Purity
- 97%
- Packaging
- 1g
- Price
- $4500
- Updated
- 2021/12/16
- Product number
- A207079
- Product name
- 4-(2-Fluoro-4-nitrophenoxy)quinolin-7-ol
- Purity
- 95+%
- Packaging
- 100mg
- Price
- $17
- Updated
- 2021/12/16
- Product number
- A207079
- Product name
- 4-(2-Fluoro-4-nitrophenoxy)quinolin-7-ol
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $26
- Updated
- 2021/12/16
4-(2-fluoro-4-nitrophenoxy)quinolin-7-ol Chemical Properties,Usage,Production
Synthesis
1394820-97-3
1394820-98-4
Step 5) Synthesis of 4-(2-fluoro-4-nitrophenoxy)quinolin-7-ol: 7-(benzyloxy)-4-(2-fluoro-4-nitrophenoxy)quinoline (100 g, 256.4 mmol) was suspended in dioxane (425 mL) and concentrated hydrochloric acid (425 mL, 5.1 mol) was added. The reaction mixture was stirred at 100 °C for 24 hours. Upon completion of the reaction, the mixture was cooled to room temperature and the precipitated solid was collected by filtration. The resulting solid was suspended in anhydrous ethanol (100 mL), stirred and the solid was collected by filtration again. Finally, the solid was dried under vacuum at 60 °C for 12 h to give the title compound as a light-colored solid (73.3 g, 85% yield). m/z MS (ESI, cationic): 301 [M +1]+; 1H NMR (400 MHz, DMSO-d6): δ 7.06-7.07 (d, J = 6.8 Hz, 1H), 7.51-7.54 (m 1H), 7.71 (s, 1H), 7.89-7.94 (m, 1H), 8.28-8.30 (d, J = 8.8 Hz, 1H), 8.41-8.43 (d, J = 9.6 Hz, 1H), 8.51-8.54 (d, J = 10 Hz, 1H), 8.94-8.96 (d, J = 6.4 Hz, 1H), and 12.00 (s, 1H).
References
[1] Patent: US2012/219522, 2012, A1. Location in patent: Page/Page column 20
[2] Journal of Medicinal Chemistry, 2018, vol. 61, # 14, p. 6277 - 6292
4-(2-fluoro-4-nitrophenoxy)quinolin-7-ol Preparation Products And Raw materials
Raw materials
Preparation Products
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