diethyl 1H-pyrazole-4,5-dicarboxylate
- Product Name
- diethyl 1H-pyrazole-4,5-dicarboxylate
- CAS No.
- 37687-26-6
- Chemical Name
- diethyl 1H-pyrazole-4,5-dicarboxylate
- Synonyms
- diethyl 1H-pyrazole-4,5-dicarboxylate;Diethyl 1H-pyrazole-3,4-dicarboxylate;1H-Pyrazole-3,4-dicarboxylic acid diethyl ester;1H-Pyrazole-3,4-dicarboxylic acid, 3,4-diethyl ester
- CBNumber
- CB72721065
- Molecular Formula
- C9H12N2O4
- Formula Weight
- 212.2
- MOL File
- 37687-26-6.mol
diethyl 1H-pyrazole-4,5-dicarboxylate Property
- Melting point:
- 69-70 °C
- Boiling point:
- 180-185 °C(Press: 2 Torr)
- Density
- 1.249±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 8.74±0.50(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- D482970
- Product name
- diethyl1H-pyrazole-3,4-dicarboxylate
- Packaging
- 500mg
- Price
- $350
- Updated
- 2021/12/16
- Product number
- D482970
- Product name
- diethyl1H-pyrazole-3,4-dicarboxylate
- Packaging
- 50mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- 9869AH
- Product name
- 1H-Pyrazole-3,4-dicarboxylicaciddiethylester
- Packaging
- 10g
- Price
- $1603
- Updated
- 2021/12/16
- Product number
- 9869AH
- Product name
- 1H-Pyrazole-3,4-dicarboxylicaciddiethylester
- Packaging
- 100mg
- Price
- $131
- Updated
- 2021/12/16
- Product number
- 68R0450
- Product name
- 1H-Pyrazole-3,4-dicarboxylicaciddiethylester
- Purity
- 96%
- Packaging
- 500mg
- Price
- $149
- Updated
- 2021/12/16
diethyl 1H-pyrazole-4,5-dicarboxylate Chemical Properties,Usage,Production
Synthesis
130187-88-1
37687-26-6
To a stirred solution of 3,4-dicyano-1H-pyrazole (45 g, 185 mmol) in ethanol (150 mL) was added hydrazine hydrochloride (12.67 g, 185 mmol) and the reaction mixture was stirred at room temperature overnight. Upon completion of the reaction, the volatile solvent was removed by rotary evaporator under reduced pressure. The crude product was dissolved in water and extracted with ethyl acetate (3 x 50 mL). The organic layers were combined, dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The resulting crude product was purified by an ISCO automated fast chromatography system using ethyl acetate and hexane as eluents to afford diethyl 1H-pyrazole-3,4-dicarboxylate (21.00 g, 97 mmol, 52.4% yield). Mass spectrum (electrospray ionization): m/z = 211 [M-H]+; 1H NMR (300 MHz, CDCl3) δ ppm 8.22 (s, 1H), 4.48 (q, J = 7.11 Hz, 2H), 4.36 (q, J = 7.18 Hz, 2H), 1.33-1.49 (m, 6H).
References
[1] Journal of Heterocyclic Chemistry, 2003, vol. 40, # 3, p. 487 - 498
[2] Patent: US9273058, 2016, B2. Location in patent: Page/Page column 147; 148; 150; 151
[3] Patent: US2011/71128, 2011, A1. Location in patent: Page/Page column 15
[4] Patent: WO2011/36127, 2011, A1. Location in patent: Page/Page column 41-42
diethyl 1H-pyrazole-4,5-dicarboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
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