Thiazolidine,3-[(2S,3S)-2-aMino-3-Methyl-1-oxopentyl]-, (2E)-2-butenedioate (2:1)
- Product Name
- Thiazolidine,3-[(2S,3S)-2-aMino-3-Methyl-1-oxopentyl]-, (2E)-2-butenedioate (2:1)
- CAS No.
- 251572-86-8
- Chemical Name
- Thiazolidine,3-[(2S,3S)-2-aMino-3-Methyl-1-oxopentyl]-, (2E)-2-butenedioate (2:1)
- Synonyms
- P32/98 (hemifumarate);WEOXCUQGVBLKQX-CXOKTDEKSA-N;Thiazolidine,3-[(2S,3S)-2-aMino-3-Methyl-1-oxopentyl]-, (2E)-2-butenedioate (2;Thiazolidine,3-[(2S,3S)-2-aMino-3-Methyl-1-oxopentyl]-, (2E)-2-butenedioate (2:1)
- CBNumber
- CB72721146
- Molecular Formula
- C13H22N2O5S
- Formula Weight
- 318.39
- MOL File
- 251572-86-8.mol
Thiazolidine,3-[(2S,3S)-2-aMino-3-Methyl-1-oxopentyl]-, (2E)-2-butenedioate (2:1) Property
- storage temp.
- Store at -20°C
- solubility
- ≤1mg/ml in ethanol;15mg/ml in DMSO;5mg/ml in dimethyl formamide
- form
- crystalline solid
N-Bromosuccinimide Price
- Product number
- 16887
- Product name
- P32/98 (hemifumarate)
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $49
- Updated
- 2024/03/01
- Product number
- 16887
- Product name
- P32/98 (hemifumarate)
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $85
- Updated
- 2024/03/01
- Product number
- 16887
- Product name
- P32/98 (hemifumarate)
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $120
- Updated
- 2024/03/01
- Product number
- P122490
- Product name
- P32/98
- Packaging
- 5mg
- Price
- $70
- Updated
- 2021/12/16
- Product number
- C3136
- Product name
- P32/98(hemifumarate)
- Packaging
- 5mg
- Price
- $97
- Updated
- 2021/12/16
Thiazolidine,3-[(2S,3S)-2-aMino-3-Methyl-1-oxopentyl]-, (2E)-2-butenedioate (2:1) Chemical Properties,Usage,Production
Uses
P32/98 is a dipeptidyl peptidase IV inhibitor which is used in hypertensive patients treated with antihpertensive drugs.
Biological Activity
ki: 126 nmp32/98 (hemifumarate) is an inhibitor of dpp iv.glucose-dependent insulinotropic polypeptide (gip) and glucagon-like peptide 1 (glp-1) are responsible for >50% of nutrient-stimulated insulin secretion. after being released into the circulation, gip and glp-1 are quickly inactivated by the circulating enzyme dipeptidyl peptidase iv (dpp iv).
in vitro
p32/98 was found to be able to block adipogenesis dose-dependently, starting at the concentration of 100 μm, and p32/98 could completely block adipogenesis in 3t3-l1 cell line at 500 μm concentration. in addition, the inhibitory effects of p32/98 was further confirmed by detecting the expression of adipocyte markers at the end of differentiation [1].
in vivo
in previou animal study, two groups of fa/fa zucker rats were orally treated twice daily for three months with p32/98 at 20 mg/kg/day and monthly oral glucose tolerance tests (ogtts) were conducted after drug washout. results showed that after 12 weeks of p32/98 treatment, the peak ogtt blood glucose values in the treated rats averaged 8.5 mmol/l less than in the controls. in addition, the concomitant insulin resulted in an increased early-phase insulin response in the treated group. moreover, in response to an 8.8 mmol/l glucose perfusion, pancreata from controls showed no increase in insulin secretion, while pancreata from p32/98-treated animals had a 3.2-fold rise in insulin secretion [2].
References
1. han r, wang x, bachovchin w, zukowska z, osborn jw. inhibition of dipeptidyl peptidase 8/9 impairs preadipocyte differentiation. sci rep. 2015 aug 5;5:12348. 2. j. a. pospisilik, s. g. stafford, h. u. demuth, et al. long-term treatment with the dipeptidyl peptidase iv inhibitor p32/98 causes sustained improvements in glucose tolerance, insulin sensitivity, hyperinsulinemia, and β-cell glucose responsiveness in vdf (fa/fa) zucker rats. diabetes 51, 943-950 (2002).
Thiazolidine,3-[(2S,3S)-2-aMino-3-Methyl-1-oxopentyl]-, (2E)-2-butenedioate (2:1) Preparation Products And Raw materials
Raw materials
Preparation Products
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