2-[6-(4-Chloro-phenyl)-1-Methyl-4H-3-oxa-2,5-diaza-benzo[e]azulen-4-yl]-acetaMide

Product Name: 2-[6-(4-Chloro-phenyl)-1-Methyl-4H-3-oxa-2,5-diaza-benzo[e]azulen-4-yl]-acetaMide
CAS No.: 1380087-89-7
Chemical Name: 2-[6-(4-Chloro-phenyl)-1-Methyl-4H-3-oxa-2,5-diaza-benzo[e]azulen-4-yl]-acetaMide
Synonyms: Pelabresib;CPI-0610;0610;CPI0160;CP1-0610;Pelabresib (CPI-0610);Pelabresib (CPI-0610) ，S7853;(4S)-6-(4-Chlorophenyl)-1-methyl-4H-isoxazolo[5,4-d][2]benzazepine-4-acetamide;2-[6-(4-Chloro-phenyl)-1-Methyl-4H-3-oxa-2,5-diaza-benzo[e]azulen-4-yl]-acetaMide;4H-Isoxazolo[5,4-d][2]benzazepine-4-acetamide, 6-(4-chlorophenyl)-1-methyl-, (4S)-
CBNumber: CB72727784
Molecular Formula: C20H16ClN3O2
Formula Weight: 365.81
MOL File: 1380087-89-7.mol

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2-[6-(4-Chloro-phenyl)-1-Methyl-4H-3-oxa-2,5-diaza-benzo[e]azulen-4-yl]-acetaMide Property

Boiling point:: 622.8±55.0 °C(Predicted)
Density: 1.41±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : 100 mg/mL (273.37 mM; Need ultrasonic)
form: Powder
pka: 16.07±0.40(Predicted)
color: White to off-white
InChI: InChI=1S/C20H16ClN3O2/c1-11-18-14-4-2-3-5-15(14)19(12-6-8-13(21)9-7-12)23-16(10-17(22)25)20(18)26-24-11/h2-9,16H,10H2,1H3,(H2,22,25)/t16-/m0/s1
InChIKey: GCWIQUVXWZWCLE-INIZCTEOSA-N
SMILES: N1=C(C2=CC=C(Cl)C=C2)C2=CC=CC=C2C2C(C)=NOC=2[C@@H]1CC(N)=O

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ApexBio Technology

Product number: B5887
Product name: BETbromodomaininhibitor
Packaging: 10mM(in 1mL DMSO)
Price: $90
Updated: 2021/12/16

ApexBio Technology

Product number: B5887
Product name: BETbromodomaininhibitor
Packaging: 10mg
Price: $150
Updated: 2021/12/16

Biosynth Carbosynth

Product number: BC177446
Product name: CPI 0610 NEW
Packaging: 25mg
Price: $250
Updated: 2021/12/16

Biosynth Carbosynth

Product number: BC177446
Product name: CPI 0610 NEW
Packaging: 50mg
Price: $395
Updated: 2021/12/16

Biosynth Carbosynth

Product number: BC177446
Product name: CPI 0610 NEW
Packaging: 100mg
Price: $530
Updated: 2021/12/16

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2-[6-(4-Chloro-phenyl)-1-Methyl-4H-3-oxa-2,5-diaza-benzo[e]azulen-4-yl]-acetaMide Chemical Properties,Usage,Production

Uses

BET Bromodomain Inhibitor has be shown to inhibit myeloma cell proliferation in clinically relevant models.

in vivo

Pelabresib (30-60 mg/kg; oral administration; for 28 days; MV-4-11 mouse xenograft model) treatment results in substantial suppression of tumor growth over the time period examined (41%, 80%, and 74% tumor growth inhibition, respectively), without any significant body weight loss in the animals^[1].

Animal Model:	MV-4-11 mouse xenograft model^[1]
Dosage:	30 mg/kg once daily, 30 mg/kg twice daily, or 60 mg/kg once daily
Administration:	Oral administration; for 28 days
Result:	Suppressed of tumor growth, without any significant body weight loss in the animals.

IC 50

BRD4-BD1: 39 nM (IC₅₀)

2-[6-(4-Chloro-phenyl)-1-Methyl-4H-3-oxa-2,5-diaza-benzo[e]azulen-4-yl]-acetaMide Preparation Products And Raw materials

Raw materials

Preparation Products

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2-[6-(4-Chloro-phenyl)-1-Methyl-4H-3-oxa-2,5-diaza-benzo[e]azulen-4-yl]-acetaMide Suppliers

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1380087-89-7, 2-[6-(4-Chloro-phenyl)-1-Methyl-4H-3-oxa-2,5-diaza-benzo[e]azulen-4-yl]-acetaMideRelated Search:

Bet Bromodomain Inhibitor

(4S)-6-(4-Chlorophenyl)-1-methyl-4H-isoxazolo[5,4-d][2]benzazepine-4-acetamide

CPI0160

CPI-0610

2-[6-(4-Chloro-phenyl)-1-Methyl-4H-3-oxa-2,5-diaza-benzo[e]azulen-4-yl]-acetaMide

2-((4S)-6-(4-chlorophenyl)-1-methyl-4H-benzo[c]isoxazolo[4,5-e]azepin-4-yl)acetamide

4H-Isoxazolo[5,4-d][2]benzazepine-4-acetamide, 6-(4-chlorophenyl)-1-methyl-, (4S)-

Pelabresib

0610

Pelabresib (CPI-0610)

CP1-0610

(S)-2-(6-(4-Chlorophenyl)-1-methyl-4H-benzo[c]isoxazolo[4,5-e]azepin-4-yl)acetamide

Pelabresib (CPI-0610) ，S7853

1380087-89-7

Inhibitors