ChemicalBook > CAS DataBase List > 2-(N-(5-chloro-2-Methylphenyl)MethylsulfonaMido)-N-(2,6-difluorophenyl)acetaMide

2-(N-(5-chloro-2-Methylphenyl)MethylsulfonaMido)-N-(2,6-difluorophenyl)acetaMide

Product Name
2-(N-(5-chloro-2-Methylphenyl)MethylsulfonaMido)-N-(2,6-difluorophenyl)acetaMide
CAS No.
708219-39-0
Chemical Name
2-(N-(5-chloro-2-Methylphenyl)MethylsulfonaMido)-N-(2,6-difluorophenyl)acetaMide
Synonyms
FPH1;CS-2645;BRD-6125;FPH1(BRD-6125);FPH1;BRD-6125;BRD 6125;BRD6125;inhibit,FPH1,BRD6125,BRD 6125,FPH 1,FPH-1,Inhibitor;2-(N-(5-chloro-2-Methylphenyl)MethylsulfonaMido)-N-(2,6-difluorophenyl)acetaMide;2-[(5-Chloro-2-methylphenyl)(methylsulfonyl)amino]-N-(2,6-difluorophenyl)-acetamide;Acetamide, 2-[(5-chloro-2-methylphenyl)(methylsulfonyl)amino]-N-(2,6-difluorophenyl)-
CBNumber
CB72729652
Molecular Formula
C16H15ClF2N2O3S
Formula Weight
388.82
MOL File
708219-39-0.mol
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2-(N-(5-chloro-2-Methylphenyl)MethylsulfonaMido)-N-(2,6-difluorophenyl)acetaMide Property

Density 
1.480±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Store in freezer, under -20°C
solubility 
DMSO: soluble20mg/mL, clear
pka
10.87±0.70(Predicted)
form 
powder
color 
white to beige
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Safety

Hazard Codes 
Xn
Risk Statements 
22-36/38
Safety Statements 
26
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0827
Product name
FPH1
Purity
≥98% (HPLC)
Packaging
5mg
Price
$118
Updated
2024/03/01
Sigma-Aldrich
Product number
SML0827
Product name
FPH1
Purity
≥98% (HPLC)
Packaging
25mg
Price
$479
Updated
2024/03/01
Cayman Chemical
Product number
21804
Product name
BRD6125
Purity
≥98%
Packaging
1mg
Price
$49
Updated
2024/03/01
Cayman Chemical
Product number
21804
Product name
BRD6125
Purity
≥98%
Packaging
5mg
Price
$96
Updated
2024/03/01
Cayman Chemical
Product number
21804
Product name
BRD6125
Purity
≥98%
Packaging
10mg
Price
$143
Updated
2024/03/01
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2-(N-(5-chloro-2-Methylphenyl)MethylsulfonaMido)-N-(2,6-difluorophenyl)acetaMide Chemical Properties,Usage,Production

Uses

2-(N-(5-Chloro-2-methylphenyl)methylsulfonamido)-N-(2,6-difluorophenyl)acetamide is a small molecule that enhances hepatocyte functions and promotes the differentiation if induced pluripotent stem cell-derived hepatocytes towards a more mature phenotype than what was previously obtainable.

Biological Activity

fph1 is a small molecule that promotes the functional proliferation of primary hepatocytes [1].fph1 belongs to the functional proliferation hits which are screened out by their ability to permit renewable sourcing of functional human hepatocytes. this ability of fph1 is not dependent on the donors of the hepatocytes. it has been found that fph1 was active against the primary human hepatocytes from six cell sources of genetically diverse individuals. besides that, fph1 can affect the hepatocyte functions with promoting albumin secretion during the differentiation of ips cells into iheps. moreover, treatment of fph1 also resulted in the increase of cyp3a4 levels and the decrease of afp secretion [1].

References

[1] shan j, schwartz r e, ross n t, et al. identification of small molecules for human hepatocyte expansion and ips differentiation. nature chemical biology, 2013.

2-(N-(5-chloro-2-Methylphenyl)MethylsulfonaMido)-N-(2,6-difluorophenyl)acetaMide Preparation Products And Raw materials

Raw materials

Preparation Products

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2-(N-(5-chloro-2-Methylphenyl)MethylsulfonaMido)-N-(2,6-difluorophenyl)acetaMide Suppliers

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708219-39-0, 2-(N-(5-chloro-2-Methylphenyl)MethylsulfonaMido)-N-(2,6-difluorophenyl)acetaMideRelated Search:

FPH2

  • 2-[(5-Chloro-2-methylphenyl)(methylsulfonyl)amino]-N-(2,6-difluorophenyl)-acetamide
  • BRD-6125
  • FPH1
  • FPH1(BRD-6125)
  • 2-(N-(5-chloro-2-Methylphenyl)MethylsulfonaMido)-N-(2,6-difluorophenyl)acetaMide
  • CS-2645
  • FPH1;BRD-6125;BRD 6125;BRD6125
  • Acetamide, 2-[(5-chloro-2-methylphenyl)(methylsulfonyl)amino]-N-(2,6-difluorophenyl)-
  • inhibit,FPH1,BRD6125,BRD 6125,FPH 1,FPH-1,Inhibitor
  • 708219-39-0
  • C16H15ClF2N2O3S
  • Inhibitors