ChemicalBook > CAS DataBase List > (4-Methyl-3-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)phenyl)Methanol

(4-Methyl-3-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)phenyl)Methanol

Product Name: (4-Methyl-3-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)phenyl)Methanol
CAS No.: 1400755-04-5
Chemical Name: (4-Methyl-3-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)phenyl)Methanol
Synonyms: (5-(HYDROXYMETHYL)-2-METHYLPHENYL)BORONIC ACID PINACOL ESTER;4-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzenemethanol;(4-Methyl-3-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)phenyl)Methanol;Benzenemethanol, 4-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-
CBNumber: CB72729713
Molecular Formula: C14H21BO3
Formula Weight: 248.13
MOL File: 1400755-04-5.mol

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(4-Methyl-3-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)phenyl)Methanol Property

Boiling point:: 379.6±37.0 °C(Predicted)
Density: 1.05±0.1 g/cm3(Predicted)
storage temp.: Inert atmosphere,Room Temperature
pka: 14.68±0.10(Predicted)
Appearance: Off-white to pink Solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-W001014
Product name: (4-Methyl-3-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)phenyl)Methanol
Purity: ≥97.0%
Packaging: 250mg
Price: $64
Updated: 2021/12/16

ChemScene

Product number: CS-W001014
Product name: (4-Methyl-3-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)phenyl)Methanol
Purity: ≥97.0%
Packaging: 1g
Price: $166
Updated: 2021/12/16

AK Scientific

Product number: 9952AL
Product name: (4-Methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanol
Packaging: 1g
Price: $436
Updated: 2021/12/16

BLDpharm

Product number: BD287679
Product name: (4-Methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanol
Purity: 97%
Packaging: 100mg
Price: $43
Updated: 2021/12/16

Ambeed

Product number: A129162
Product name: (4-Methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanol
Purity: 97%
Packaging: 100mg
Price: $43
Updated: 2021/12/16

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(4-Methyl-3-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)phenyl)Methanol Chemical Properties,Usage,Production

Synthesis

68120-35-4

73183-34-3

1400755-04-5

A mixture was prepared from 3-bromo-4-methylbenzyl alcohol (8.5 g, 42.2 mmol) and pinacol ester of bis(boronic acid) (11.8 g, 46.50 mmol) in 1,4-dioxane (50 mL) and degassed under nitrogen atmosphere for 10 min. Subsequently, potassium acetate (8.2 g, 84.55 mmol) and [1,1'-bis(diphenylphosphino)ferrocene]palladium(II) dichloride-CH2Cl2 (1.54 g, 2.11 mmol) were added to the mixture, and the reaction system was heated to 100 °C for 15 hours. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure and the residue was diluted with water and extracted with ethyl acetate (2 x 150 mL). The organic phases were combined, washed sequentially with water and brine, dried over anhydrous sodium sulfate, filtered and concentrated. The crude product was purified by rapid chromatography on silica gel (ethyl acetate:hexane = 70:30) to afford the target product (4-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanol as a brown liquid (5.0 g, 84% yield). The structure of the product was confirmed by 1H NMR (400 MHz, DMSO-d6): δ 7.59 (d, J = 1.72 Hz, 1H), 7.25 (dd, J = 7.76, 1.88 Hz, 1H), 7.11 (d, J = 7.76 Hz, 1H), 5.10 (t, J = 5.72 Hz, 1H), 4.43 (d, J = 5.72 Hz, 2H), 2.42 (s, 3H), 1.29 (s, 12H).

References

[1] Patent: WO2014/121942, 2014, A1. Location in patent: Page/Page column 50
[2] Patent: WO2014/22528, 2014, A1. Location in patent: Page/Page column 122
[3] Patent: WO2014/19186, 2014, A1. Location in patent: Page/Page column 108

(4-Methyl-3-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)phenyl)Methanol Preparation Products And Raw materials

Raw materials

Preparation Products

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(4-Methyl-3-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)phenyl)Methanol Suppliers

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