2-chloro-5-(Methylthio)pyriMidine

Product Name: 2-chloro-5-(Methylthio)pyriMidine
CAS No.: 115581-36-7
Chemical Name: 2-chloro-5-(Methylthio)pyriMidine
Synonyms: 2-chloro-5-(Methylthio)pyriMidine;Pyrimidine, 2-chloro-5-(methylthio)-;2-Chloro-5-methylsulfanyl-pyrimidine;2-chloro-5-((methylthio)methyl)pyrimidine
CBNumber: CB72731806
Molecular Formula: C5H5ClN2S
Formula Weight: 160.62
MOL File: 115581-36-7.mol

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2-chloro-5-(Methylthio)pyriMidine Property

Boiling point:: 308.3±15.0 °C(Predicted)
Density: 1.37±0.1 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: -1.78±0.22(Predicted)
Appearance: Off-white to yellow Solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: C369958
Product name: 2-Chloro-5-(methylthio)pyrimidine
Packaging: 10mg
Price: $90
Updated: 2021/12/16

AK Scientific

Product number: 9472CZ
Product name: 2-Chloro-5-(methylthio)pyrimidine
Packaging: 250mg
Price: $297
Updated: 2021/12/16

AK Scientific

Product number: 9472CZ
Product name: 2-Chloro-5-(methylthio)pyrimidine
Packaging: 1g
Price: $675
Updated: 2021/12/16

AK Scientific

Product number: 9472CZ
Product name: 2-Chloro-5-(methylthio)pyrimidine
Packaging: 5g
Price: $1774
Updated: 2021/12/16

Chemenu

Product number: CM167011
Product name: 2-chloro-5-(methylthio)pyrimidine
Purity: 95%
Packaging: 5g
Price: $1103
Updated: 2021/12/16

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2-chloro-5-(Methylthio)pyriMidine Chemical Properties,Usage,Production

Synthesis

624-92-0

32779-36-5

115581-36-7

General procedure for the synthesis of 2-chloro-5-(methylthio)pyrimidine from 5-bromo-2-chloropyrimidine and dimethyl disulfide: 1.00 g (5.17 mmol) of 5-bromo-2-chloropyrimidine and 551 μl (6.20 mmol) of dimethyl disulfide were dissolved in 26 ml of tetrahydrofuran and cooled to -78 °C. Under stirring, 1.89 ml (5.17 mmol) of 2.73N n-butyllithium/hexane solution was slowly added, keeping the reaction temperature at -78 °C, and stirring was continued for 2 hours. Upon completion of the reaction, the reaction was quenched by adding saturated aqueous ammonium chloride solution to the reaction mixture and the organic phase was extracted with ethyl acetate. The organic layers were combined, washed with saturated aqueous sodium chloride solution and dried over anhydrous sodium sulfate. The solvent was removed by distillation under reduced pressure to give the crude product. Purification by silica gel column chromatography [eluent: n-hexane/ethyl acetate = 90/10 (V/V)], the fraction containing the target compound was collected and concentrated under reduced pressure to give 149 mg of 2-chloro-5-(methylthio)pyrimidine as a white solid (yield: 18%). The product was characterized by 1H-NMR (500 MHz, CDCl3): δ 8.49 (2H, s), 2.54 (3H, s).

References

[1] Patent: US2013/109653, 2013, A1. Location in patent: Paragraph 0831-0833

2-chloro-5-(Methylthio)pyriMidine Preparation Products And Raw materials

Raw materials

Preparation Products

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2-chloro-5-(Methylthio)pyriMidine Suppliers

China 45 India 1 United States 2 Global 48

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View Lastest Price from 2-chloro-5-(Methylthio)pyriMidine manufacturers

Career Henan Chemical Co

Product: 2-chloro-5-(Methylthio)pyriMidine 115581-36-7
Price: US $9.80/KG
Min. Order: 1KG
Purity: 97%-99%
Supply Ability: 1kg -1000kg
Release date: 2020-01-03

115581-36-7, 2-chloro-5-(Methylthio)pyriMidineRelated Search:

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115581-36-7