7-Benzyl-4,7-diazaspiro[2.5]octane
Uses- Product Name
- 7-Benzyl-4,7-diazaspiro[2.5]octane
- CAS No.
- 1222106-45-7
- Chemical Name
- 7-Benzyl-4,7-diazaspiro[2.5]octane
- Synonyms
- 7-Benzyl-4,7-diazaspiro[2.5]octane;4,7-Diazaspiro[2.5]octane, 7-(phenylmethyl)-
- CBNumber
- CB72732676
- Molecular Formula
- C13H18N2
- Formula Weight
- 202.3
- MOL File
- 1222106-45-7.mol
7-Benzyl-4,7-diazaspiro[2.5]octane Property
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- Appearance
- Colorless to light yellow Liquid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
N-Bromosuccinimide Price
- Product number
- 1085DP
- Product name
- 7-Benzyl-4,7-diazaspiro[2.5]octane
- Packaging
- 50mg
- Price
- $279
- Updated
- 2021/12/16
- Product number
- CD11323785
- Product name
- 7-Benzyl-4,7-diazaspiro[2.5]octane
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $332
- Updated
- 2021/12/16
- Product number
- A542123
- Product name
- 7-Benzyl-4,7-diazaspiro[2.5]octane
- Purity
- 95+%
- Packaging
- 1g
- Price
- $361
- Updated
- 2021/12/16
- Product number
- CM138879
- Product name
- 7-benzyl-4,7-diazaspiro[2.5]octane
- Purity
- 95%
- Packaging
- 1g
- Price
- $785
- Updated
- 2021/12/16
- Product number
- 1222106457
- Product name
- 7-Benzyl-4,7-diazaspiro[2.5]octane
- Packaging
- 1g
- Price
- $798.48
- Updated
- 2021/12/16
7-Benzyl-4,7-diazaspiro[2.5]octane Chemical Properties,Usage,Production
Uses
7-Benzyl-4,7-diaza-spiro[2.5]octane is a useful research chemical.
Synthesis
1222106-43-5
1222106-45-7
The general procedure for the synthesis of 7-benzyl-4,7-diazaspiro[2.5]octane-5,8-dione from 7-benzyl-4,7-diazaspiro[2.5]octane was carried out as follows: to a solution of 7-benzyl-4,7-diazaspiro[2.5]octane-5,8-dione (20 g, 86.8 mmol) in tetrahydrofuran (200 ml), cooled in an ice bath, was slowly Borane-tetrahydrofuran complex (0.93 M tetrahydrofuran solution, 375 ml, 0.35 mol) was added. Subsequently, the reaction mixture was heated to reflux for 19 hours. After completion of the reaction, methanol (130 ml) was slowly added to the reaction mixture under ice bath cooling and the mixture was stirred for 60 minutes. Afterwards, the solvent was removed by concentration under reduced pressure. To the concentrated residue, ethanol (450 ml), water (150 ml) and triethylamine (150 ml) were added and the mixture was heated to reflux for 2 hours. The solvent was again concentrated under reduced pressure to remove the solvent. The residue was diluted with ethyl acetate, washed sequentially with saturated aqueous sodium bicarbonate and saturated saline, and the organic phase was dried with anhydrous sodium sulfate. After removal of the solvent by evaporation under reduced pressure, the residue was purified by silica gel column chromatography (eluent ratio of chloroform:methanol=10:1) to afford 7-benzyl-4,7-diazaspiro[2.5]octane (10.4 g, 59% yield) as a colorless oil.1H-NMR (CDCl3) δ: 0.41-0.44 (2H, m), 0.57-0.60 (2H, m) , 1.49 (1H, br), 2.22 (2H, s), 2.45 (2H, brs), 2.97 (2H, t, J=4.9Hz), 3.50 (2H, s), 7.22-7.32 (5H, m).
References
[1] Patent: US2010/130492, 2010, A1. Location in patent: Page/Page column 154
[2] Patent: EP2380892, 2011, A1. Location in patent: Page/Page column 55; 56
[3] Patent: CN106749233, 2017, A. Location in patent: Paragraph 0181; 0182
7-Benzyl-4,7-diazaspiro[2.5]octane Preparation Products And Raw materials
Raw materials
Preparation Products
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