Methyl 4-cyanobicyclo[2.2.2]octane-1-carboxylate

Product Name: Methyl 4-cyanobicyclo[2.2.2]octane-1-carboxylate
CAS No.: 54202-05-0
Chemical Name: Methyl 4-cyanobicyclo[2.2.2]octane-1-carboxylate
Synonyms: Methyl 4-cyanobicyclo[2.2.2]octane-1-carboxylate;Bicyclo[2.2.2]octane-1-carboxylic acid, 4-cyano-, methyl ester
CBNumber: CB72734438
Molecular Formula: C11H15NO2
Formula Weight: 193.24
MOL File: 54202-05-0.mol

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Methyl 4-cyanobicyclo[2.2.2]octane-1-carboxylate Property

Boiling point:: 292.6±40.0 °C(Predicted)
Density: 1.13±0.1 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
Appearance: White to off-white Solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

AK Scientific

Product number: 7793AB
Product name: Methyl4-cyanobicyclo[2.2.2]octane-1-carboxylate
Packaging: 250mg
Price: $336
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0393164
Product name: METHYL-4-CYANOBICYCLO[2.2.2]OCTANE-1-CARBOXYLATE
Purity: 95.00%
Packaging: 5MG
Price: $498.53
Updated: 2021/12/16

Activate Scientific

Product number: AS111306
Product name: Methyl4-cyanobicyclo[2.2.2]octane-1-carboxylate
Purity: 95%
Packaging: 1g
Price: $655
Updated: 2021/12/16

Chemenu

Product number: CM201446
Product name: methyl4-cyanobicyclo[2.2.2]octane-1-carboxylate
Purity: 95%
Packaging: 1g
Price: $499
Updated: 2021/12/16

Crysdot

Product number: CD13011173
Product name: Methyl4-cyanobicyclo[2.2.2]octane-1-carboxylate
Purity: 95+%
Packaging: 1g
Price: $529
Updated: 2021/12/16

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Methyl 4-cyanobicyclo[2.2.2]octane-1-carboxylate Chemical Properties,Usage,Production

Synthesis

135908-42-8

54202-05-0

The general procedure for the synthesis of methyl 4-cyanobicyclo[2.2.2]octane-1-carboxylate from methyl 4-carbamoylbicyclo[2.2.2]octane-1-carboxylate was as follows: to a solution of pyridine (10 mL) containing methyl 4-carbamoylbicyclo[2.2.2]octane-1-carboxylate (228 mg) and imidazole (147 mg) was slowly added, at 0 °C, a solution of phosphorus oxychloride (POCl3, 0.40 mL). The reaction mixture was stirred continuously at 0 °C for 1 hour. Subsequently, the reaction mixture was poured into a mixture containing ice, sodium chloride (NaCl) and ethyl acetate (EtOAc). The organic phase was separated and washed with aqueous 1N hydrochloric acid until the aqueous phase was acidic. The organic phase was dried over anhydrous magnesium sulfate (MgSO4), filtered and concentrated to afford the target product methyl 4-cyanobicyclo[2.2.2]octane-1-carboxylate (137 mg, 72% yield). Mass spectral analysis showed [MH]+ = 194.

References

[1] Patent: WO2006/128184, 2006, A2. Location in patent: Page/Page column 166
[2] Patent: WO2008/63671, 2008, A2. Location in patent: Page/Page column 178-179
[3] Patent: WO2008/100423, 2008, A1. Location in patent: Page/Page column 82-83

Methyl 4-cyanobicyclo[2.2.2]octane-1-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

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Methyl 4-cyanobicyclo[2.2.2]octane-1-carboxylate Suppliers

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54202-05-0, Methyl 4-cyanobicyclo[2.2.2]octane-1-carboxylateRelated Search:

Methyl 4-cyanobicyclo[2.2.2]octane-1-carboxylate

Bicyclo[2.2.2]octane-1-carboxylic acid, 4-cyano-, methyl ester

54202-05-0