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Rhosin (hydrochloride)

Product Name
Rhosin (hydrochloride)
CAS No.
1281870-42-5
Chemical Name
Rhosin (hydrochloride)
Synonyms
Rhosin HCl;G04 HYDROCHLORIDE;Rhosin (hydrochloride);Rhosin hydrochloride, 10 mM in DMSO;Rhosin hydrochloride (G04 hydrochloride);D-Tryptophan (2E)-2-(6-quinoxalinylmethylene)hydrazide hydrochloride;(R,E)-2-amino-3-(1H-indol-3-yl)-N'-(quinoxalin-6-ylmethylene)propanehydrazide hydrochloride;(2R)-2-amino-3-(1H-indol-3-yl)-N'-[(quinoxalin-6-yl)methylidene]propanehydrazide hydrochloride;plasticity,D1-MSN,MCF7,Apoptosis,hyperexcitability,Rhosin hydrochloride,Ras,stress,Rhosin,selective,inhibit,cells,Inhibitor,resiliency
CBNumber
CB72735536
Molecular Formula
C20H19ClN6O
Formula Weight
394.86
MOL File
1281870-42-5.mol
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Rhosin (hydrochloride) Property

storage temp. 
Store at -20°C
solubility 
DMF: 10 mg/ml; DMSO: 5 mg/ml; Ethanol: 5 mg/ml; PBS (pH 7.2): insol
form 
A solid
color 
Light yellow to yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Tocris
Product number
5003
Product name
Rhosinhydrochloride
Purity
≥98%(HPLC)
Packaging
10
Price
$108
Updated
2021/12/16
Tocris
Product number
5003
Product name
Rhosinhydrochloride
Purity
≥98%(HPLC)
Packaging
50
Price
$454
Updated
2021/12/16
Usbiological
Product number
256452
Product name
Rhosin hydrochloride
Packaging
10mg
Price
$358
Updated
2021/12/16
TRC
Product number
R414003
Product name
RhosinHydrochloride
Packaging
50mg
Price
$420
Updated
2021/12/16
ChemScene
Product number
CS-3877
Product name
Rhosin(hydrochloride)
Purity
99.93%
Packaging
5mg
Price
$420
Updated
2021/12/16
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Rhosin (hydrochloride) Chemical Properties,Usage,Production

Uses

Rhosin hydrochloride is the hydrochloride salt of rhosin (CAS# 1173671-63-0) which is a D-tryptophan derivative and an inhibitor of Rho GTPases with potential application in reversing chemotherapy resistance in diffuse-type gastric adenocarinoma.

in vivo

Rhosin (40 mg/kg; i.p.) treatment prevents social avoidance caused by social defeat stress. Rhosin also blocks sucrose preference deficits induced by defeat in C57Bl6/J (Jackson) mice[3].
Rhosin (30 μM; bilateral, intra- Nucleus Accumbens (NAc) infusions) attenuates stress-induced social avoidance. Rhosin blocks stress-induced hyperexcitability in NAc dopamine 1 receptor medium spiny neurons (D1-MSNs). Rhosin prevents decreased excitatory transmission on NAc D1-MSNs. Rhosin enhances spine density in defeat mice[3].

Animal Model:D1-GFP or D2-GFP hemizygote mice on a C57BL/6J background[3]
Dosage:40 mg/kg
Administration:I.p.
Result:Rhosin was systemically administered 15 min prior to defeat to block RhoA activation. While defeat significantly reduced the time that experimental mice spent interacting with a novel mouse, Rhosin administration suppressed this effect without affecting locomotor behaviors.

storage

Store at -20°C

Rhosin (hydrochloride) Preparation Products And Raw materials

Raw materials

Preparation Products

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Rhosin (hydrochloride) Suppliers

China 77 United Kingdom 1 United States 7 Global 85
Haoyuan Chemexpress Co., Ltd.
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021-58950125
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(86) 21-58955996
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info@chemexpress.com
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China
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7552
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61
ShangHai Caerulum Pharma Discovery Co., Ltd.
Tel
18149758185 18149758185;
Email
sales-cpd@caerulumpharma.com
Country
China
ProdList
3505
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58
Bide Pharmatech Ltd.
Tel
400-400-164-7117 18317119277
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
40000
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60
Sichuan Wei Keqi Biological Technology Co., Ltd.
Tel
028-81700200 18116577057
Fax
028-81705658
Email
3003855609@qq.com
Country
China
ProdList
7778
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LETOPHARM LIMITED
Tel
+86-21-5821 5861
Fax
+86-21-5106 2861
Email
sales@letopharm.com
Country
China
ProdList
2384
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58
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
Country
China
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4795
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55
BOC Sciences
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16314854226
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info@bocsci.com
Country
United States
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Shanghai EFE Biological Technology Co., Ltd.
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021-65675885 18964387627
Fax
021-65675885
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info@efebio.com
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China
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58
Guangzhou QiYun Biotechnology Co., Ltd.
Tel
020-61288194 61288195
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020-61288700
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505721671@qq.com
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China
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58
Shanghai YuanYe Biotechnology Co., Ltd.
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021-61312847; 18021002903
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QQ:3008007432
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3008007409@qq.com
Country
China
ProdList
71826
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60

1281870-42-5, Rhosin (hydrochloride)Related Search:


  • Rhosin (hydrochloride)
  • Rhosin HCl
  • (R,E)-2-amino-3-(1H-indol-3-yl)-N'-(quinoxalin-6-ylmethylene)propanehydrazide hydrochloride
  • D-Tryptophan (2E)-2-(6-quinoxalinylmethylene)hydrazide hydrochloride
  • G04 HYDROCHLORIDE
  • (2R)-2-amino-3-(1H-indol-3-yl)-N'-[(quinoxalin-6-yl)methylidene]propanehydrazide hydrochloride
  • plasticity,D1-MSN,MCF7,Apoptosis,hyperexcitability,Rhosin hydrochloride,Ras,stress,Rhosin,selective,inhibit,cells,Inhibitor,resiliency
  • Rhosin hydrochloride, 10 mM in DMSO
  • Rhosin hydrochloride (G04 hydrochloride)
  • 1281870-42-5