3-((benzyloxy)methyl)oxetane
- Product Name
- 3-((benzyloxy)methyl)oxetane
- CAS No.
- 1003013-76-0
- Chemical Name
- 3-((benzyloxy)methyl)oxetane
- Synonyms
- 3-((benzyloxy)methyl)oxetane;3-[(Phenylmethoxy)methyl]oxetane;Oxetane, 3-[(phenylmethoxy)methyl]-;5-(Methanesulfonyl)ethylsuccinimidyl
- CBNumber
- CB72736649
- Molecular Formula
- C11H14O2
- Formula Weight
- 178.23
- MOL File
- 1003013-76-0.mol
3-((benzyloxy)methyl)oxetane Property
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- A213111
- Product name
- 3-((Benzyloxy)methyl)oxetane
- Purity
- 95+%
- Packaging
- 100mg
- Price
- $23
- Updated
- 2021/12/16
- Product number
- A213111
- Product name
- 3-((Benzyloxy)methyl)oxetane
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- A213111
- Product name
- 3-((Benzyloxy)methyl)oxetane
- Purity
- 95+%
- Packaging
- 1g
- Price
- $119
- Updated
- 2021/12/16
- Product number
- CD11370065
- Product name
- 3-((Benzyloxy)methyl)oxetane
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $309
- Updated
- 2021/12/16
- Product number
- 1003013760
- Product name
- 3-((Benzyloxy)methyl)oxetane
- Packaging
- 1g
- Price
- $618.13
- Updated
- 2021/12/16
3-((benzyloxy)methyl)oxetane Chemical Properties,Usage,Production
Synthesis
117087-18-0
1003013-76-0
General procedure for the synthesis of 3-(benzyloxymethyl)oxetane from 2-((benzyloxy)methyl)propane-1,3-diol: the white powder (75 g, 0.38 mol) obtained in step (3) was dissolved in N,N-dimethylformamide (1 L), placed in an ice bath, and under partial protection of nitrogen, sodium hydride was added in batches (15.2 g, 0.38 mol. 60% dispersed in mineral oil). After stirring for 1 h, methanesulfonyl chloride (43 g, 0.375 mol) was added slowly and dropwise. The reaction system was gradually warmed to room temperature and stirring was continued for 2 hours. Subsequently, the system was cooled to 0 °C, sodium hydride (15.2 g, 0.38 mol) was added in batches, slowly warmed to room temperature and stirring was continued for 3 hours. The pH was adjusted to neutral with 1 M hydrochloric acid under ice bath conditions. Add 2 L of water and extract with ethyl acetate (300 mL each time, 5 times). The organic phases were combined, washed 3 times with water, dried and concentrated. The residue was dissolved in 500 mL of methanol. 100mL of petroleum ether was added to the methanol solution, stirred for 20 minutes and then layered. Repeatedly added 100mL of petroleum ether, stirred for 20 minutes, partitioned, and collected the lower layer to concentrate. Crystallization was carried out through a solvent mixture of ethyl acetate and petroleum ether (1:10) to give 53 g of white solid in 78% yield.
References
[1] Patent: CN108314665, 2018, A. Location in patent: Paragraph 0078-0080; 0128-0130
3-((benzyloxy)methyl)oxetane Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-((benzyloxy)methyl)oxetane manufacturers
- Product
- 3-((benzyloxy)methyl)oxetane 1003013-76-0
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 95%-99%
- Supply Ability
- 100kg
- Release date
- 2018-12-22