Finerenone

Product Name: Finerenone
CAS No.: 1050477-31-0
Chemical Name: Finerenone
Synonyms: Finerenone;BAY 94-8862;Finerone;(4S)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide;BAY948862;Fenaridone;Fenalidone;Non Nilidone;Mr Neri ketone;Finerenone Inn
CBNumber: CB72744895
Molecular Formula: C21H22N4O3
Formula Weight: 378.42
MOL File: 1050477-31-0.mol

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Finerenone Property

Boiling point:: 554.7±50.0 °C(Predicted)
Density: 1.29±0.1 g/cm3(Predicted)
storage temp.: -20°C
solubility: DMF: 10 mg/ml DMSO: 3 mg/ml Ethanol: insol PBS (pH 7.2): insol
pka: 14.76±0.40(Predicted)
form: solid
color: White to off-white
λmax: 255 nm
InChI: InChI=1S/C21H22N4O3/c1-5-28-21-18-17(14-7-6-13(9-22)8-15(14)27-4)16(20(23)26)12(3)25-19(18)11(2)10-24-21/h6-8,10,17,25H,5H2,1-4H3,(H2,23,26)/t17-/m1/s1
InChIKey: BTBHLEZXCOBLCY-QGZVFWFLSA-N
SMILES: N1C2=C(C(OCC)=NC=C2C)[C@H](C2=CC=C(C#N)C=C2OC)C(C(N)=O)=C1C

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H360May damage fertility or the unborn child

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0040097
Product name: Finerenone
Purity: 99.75%
Packaging: 5mg
Price: $480
Updated: 2021/12/16

ChemScene

Product number: CS-0040097
Product name: Finerenone
Purity: 99.75%
Packaging: 10mg
Price: $800
Updated: 2021/12/16

ChemScene

Product number: CS-0040097
Product name: Finerenone
Purity: 99.75%
Packaging: 25mg
Price: $1550
Updated: 2021/12/16

ChemScene

Product number: CS-0040097
Product name: Finerenone
Purity: 99.75%
Packaging: 50mg
Price: $2400
Updated: 2021/12/16

ChemScene

Product number: CS-0040097
Product name: Finerenone
Purity: 99.75%
Packaging: 100mg
Price: $3600
Updated: 2021/12/16

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Finerenone Chemical Properties,Usage,Production

Description

Finerenone is a novel mineralocorticoid receptor antagonist that has the effect of delaying the progression of chronic kidney disease. Some people may be aware of two other mineralocorticoid receptor antagonists: the diuretic antihypertensive drug spironolactone, and eplerenone.Finerenone is their cognate derivative and is a third-generation mineralocorticoid receptor antagonist. So far, finerenone is the only nonsteroidal mineralocorticoid receptor antagonist to be FDA approved. Finerenone was granted FDA approval on 9 July 2021, followed by the EMA approval on 11 March 2022.

Uses

Finerenone is the first non-steroidal selective mineralocorticoid receptor antagonist, which can be used for the treatment of diabetic nephropathy, chronic kidney disease and end-stage renal disease. It can reduce the proteinuria of patients and improve the glomerular filtration rate.

brand name

Finerenone is sold under the brand name Kerendia and Firialta.

Biological Activity

Finerenone (FIN, BAY 94-8862) is a highly selective, orally active, nonsteroidal antagonist of mineralocorticoid receptor (MR) with IC50 of 18 nM. Finerenone has the potential to study cardio-renal diseases such as type 2 diabetes and chronic kidney disease.

in vivo

Finerenone (BAY 94-8862) lowers albuminuria by >40% and significantly reduces systolic blood pressure (SBP) in Munich Wistar Fr?mter (MWF) rat.

Mode of action

Finerenone is a Nonsteroidal Mineralocorticoid-Receptor Antagonist. The mechanism of action of finerenone is as a Mineralocorticoid Receptor Antagonist. Finerenone inhibits the effects of mineralocorticoids like aldosterone and cortisol when the MR is overactivated, possibly reducing inflammation and fibrosis in the heart and kidney.

References

Kolkhof, P., Hartmann, E., Freyberger, A., et al.Effects of finerenone combined with empagliflozin in a model of hypertension-induced end-organ damage. Am. J. Nephrol. 52(8), 642-652 (2021).
DOI: 10.1159/000516213
Cardiovascular Events with Finerenone in Kidney Disease and Type 2 Diabetes.

Finerenone Preparation Products And Raw materials

Raw materials

Preparation Products

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Finerenone Suppliers

Australia 1 China 228 India 7 United States 7 Global 243

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View Lastest Price from Finerenone manufacturers

Zison Pharmaceutical (Shandong) Co., Ltd.

Product: Finerenone 1050477-31-0
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: ＞99% by HPLC
Supply Ability: 10kg/month
Release date: 2023-01-06

Nanjing Fred Technology Co., Ltd

Product: Finerenone 1050477-31-0
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99%，single impurity＜0.1
Supply Ability: 1 ton
Release date: 2024-01-04

shandong perfect biotechnology co.ltd

Product: Finerenone 1050477-31-0
Price: US $0.00/g
Min. Order: 1g
Purity: 98% HPLC
Supply Ability: 100g
Release date: 2023-08-01

1050477-31-0, FinerenoneRelated Search:

Finerenone (BAY 94-8862)

(4S)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide

BAY 94-8862

BAY948862

1,6-Naphthyridine-3-carboxamide, 4-(4-cyano-2-methoxyphenyl)-5-ethoxy-1,4-dihydro-2,8-dimethyl-, (4S)-

Finerone

Mr Neri ketone

(S)-4-(4-Cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide

Finerenone Inn

Fenaridone

Finerenone

inhibit,cardiorenal,systolic,disease,pressure,Finerenone,diabetes,chronic,type,Inhibitor,kidney,Mineralocorticoid Receptor,oral,nonsteroidal,blood

(DL)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-

(4S)-4-(4-Cyano-2-methoxyphenyl)-5-ethoxy-1,4-dihydro-2,8-dimethyl-1,6-naphthyridine-3-carboxamide (Finerenone Impurity)

Finerenone API

Finerenone In-House

BAY 94-8862 Finerenone

Fenalidone

Non Nilidone

1050477-31-0

11050477-31-0

chemical

1050477-31-0

API

1