(E)-3-(3-bromo-4,5-dihydroxyphenyl)-N-(3,4,5-trihydroxybenzyl)prop-2-enethioamide
- Product Name
- (E)-3-(3-bromo-4,5-dihydroxyphenyl)-N-(3,4,5-trihydroxybenzyl)prop-2-enethioamide
- CAS No.
- 1384426-12-3
- Chemical Name
- (E)-3-(3-bromo-4,5-dihydroxyphenyl)-N-(3,4,5-trihydroxybenzyl)prop-2-enethioamide
- Synonyms
- NT-157;CS-2283;CS-5531;AK174915;NT157;NT 157;AKOS025404921;Tyrphostin NT157;NT-157; NT 157; NT157.;NT-157;NT 157;TYRPHOSTIN NT157;NT 157 (This product is only available in Japan.)
- CBNumber
- CB72745054
- Molecular Formula
- C16H14BrNO5S
- Formula Weight
- 412.26
- MOL File
- 1384426-12-3.mol
(E)-3-(3-bromo-4,5-dihydroxyphenyl)-N-(3,4,5-trihydroxybenzyl)prop-2-enethioamide Property
- Boiling point:
- 660.3±65.0 °C(Predicted)
- Density
- 1.794±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- insoluble in H2O; ≥21.5 mg/mL in EtOH; ≥50 mg/mL in DMSO
- form
- solid
- pka
- 8.06±0.36(Predicted)
- color
- Light yellow to yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 23442
- Product name
- NT-157
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $39
- Updated
- 2021/12/16
- Product number
- 23442
- Product name
- NT-157
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $176
- Updated
- 2021/12/16
- Product number
- 23442
- Product name
- NT-157
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $312
- Updated
- 2021/12/16
- Product number
- 23442
- Product name
- NT-157
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $595
- Updated
- 2021/12/16
- Product number
- orb573093
- Product name
- NT-157
- Purity
- >98%
- Packaging
- 100mg
- Price
- $838.1
- Updated
- 2021/12/16
(E)-3-(3-bromo-4,5-dihydroxyphenyl)-N-(3,4,5-trihydroxybenzyl)prop-2-enethioamide Chemical Properties,Usage,Production
Biological Activity
nt157 is an irs-1/2 inhibitor.insulin receptor substrates 1 and 2 (irs1/2) mediate antiapoptotic and mitogenic signaling from insulin receptor (ir), insulin-like growth factor 1 receptor (igf-ir), and other oncoproteins. irs1 plays a critical role in cancer cell proliferation, and its expression is increased in many human malignancies.
in vitro
nt157 treatment was fonund to be able to lead to dose-dependent suppression of irs protein expression, inhibition of igf1r activation, inhibition of igf1-induced akt activation, but increased erk activation in nt157-treated cells. these effects were associated with decreased proliferation, increased apoptosis of lncap cells and increased g2-m arrest in pc3 cells. moreover, nt157 could significantly affect the cell migratory ability, as demonstrated by a wound-healing assay. in addition, the nt157 treatment was able to induce cell cycle arrest and inhibit igf system signaling [1].
in vivo
in previous animal study, nt157 was found to suppress androgen-responsive growth, delay crpc progression of lncap xenografts, and suppress pc3 tumor growth alone or in combination with docetaxel. this study reported the first preclinical proof-of-principle data that nt157 suppressed irs1/2 expression, delayed crpc progression, and suppressed growth of crpc tumors in vivo [1].
IC 50
0.3 to 0.8 μm
References
[1] ibuki n et al. the tyrphostin nt157 suppresses insulin receptor substrates and augments therapeutic response of prostate cancer. mol cancer ther. 2014 dec;13(12):2827-39.
(E)-3-(3-bromo-4,5-dihydroxyphenyl)-N-(3,4,5-trihydroxybenzyl)prop-2-enethioamide Preparation Products And Raw materials
Raw materials
Preparation Products
(E)-3-(3-bromo-4,5-dihydroxyphenyl)-N-(3,4,5-trihydroxybenzyl)prop-2-enethioamide Suppliers
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View Lastest Price from (E)-3-(3-bromo-4,5-dihydroxyphenyl)-N-(3,4,5-trihydroxybenzyl)prop-2-enethioamide manufacturers
- Product
- (E)-3-(3-bromo-4,5-dihydroxyphenyl)-N-(3,4,5-trihydroxybenzyl)prop-2-enethioamide 1384426-12-3
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2019-12-25