ChemicalBook > CAS DataBase List > (E)-3-(3-bromo-4,5-dihydroxyphenyl)-N-(3,4,5-trihydroxybenzyl)prop-2-enethioamide

(E)-3-(3-bromo-4,5-dihydroxyphenyl)-N-(3,4,5-trihydroxybenzyl)prop-2-enethioamide

Product Name
(E)-3-(3-bromo-4,5-dihydroxyphenyl)-N-(3,4,5-trihydroxybenzyl)prop-2-enethioamide
CAS No.
1384426-12-3
Chemical Name
(E)-3-(3-bromo-4,5-dihydroxyphenyl)-N-(3,4,5-trihydroxybenzyl)prop-2-enethioamide
Synonyms
NT-157;CS-2283;CS-5531;AK174915;NT157;NT 157;AKOS025404921;Tyrphostin NT157;NT-157; NT 157; NT157.;NT-157;NT 157;TYRPHOSTIN NT157;NT 157 (This product is only available in Japan.)
CBNumber
CB72745054
Molecular Formula
C16H14BrNO5S
Formula Weight
412.26
MOL File
1384426-12-3.mol
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(E)-3-(3-bromo-4,5-dihydroxyphenyl)-N-(3,4,5-trihydroxybenzyl)prop-2-enethioamide Property

Boiling point:
660.3±65.0 °C(Predicted)
Density 
1.794±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
insoluble in H2O; ≥21.5 mg/mL in EtOH; ≥50 mg/mL in DMSO
form 
solid
pka
8.06±0.36(Predicted)
color 
Light yellow to yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
23442
Product name
NT-157
Purity
≥98%
Packaging
1mg
Price
$39
Updated
2021/12/16
Cayman Chemical
Product number
23442
Product name
NT-157
Purity
≥98%
Packaging
5mg
Price
$176
Updated
2021/12/16
Cayman Chemical
Product number
23442
Product name
NT-157
Purity
≥98%
Packaging
10mg
Price
$312
Updated
2021/12/16
Cayman Chemical
Product number
23442
Product name
NT-157
Purity
≥98%
Packaging
25mg
Price
$595
Updated
2021/12/16
Biorbyt Ltd
Product number
orb573093
Product name
NT-157
Purity
>98%
Packaging
100mg
Price
$838.1
Updated
2021/12/16
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(E)-3-(3-bromo-4,5-dihydroxyphenyl)-N-(3,4,5-trihydroxybenzyl)prop-2-enethioamide Chemical Properties,Usage,Production

Biological Activity

nt157 is an irs-1/2 inhibitor.insulin receptor substrates 1 and 2 (irs1/2) mediate antiapoptotic and mitogenic signaling from insulin receptor (ir), insulin-like growth factor 1 receptor (igf-ir), and other oncoproteins. irs1 plays a critical role in cancer cell proliferation, and its expression is increased in many human malignancies.

in vitro

nt157 treatment was fonund to be able to lead to dose-dependent suppression of irs protein expression, inhibition of igf1r activation, inhibition of igf1-induced akt activation, but increased erk activation in nt157-treated cells. these effects were associated with decreased proliferation, increased apoptosis of lncap cells and increased g2-m arrest in pc3 cells. moreover, nt157 could significantly affect the cell migratory ability, as demonstrated by a wound-healing assay. in addition, the nt157 treatment was able to induce cell cycle arrest and inhibit igf system signaling [1].

in vivo

in previous animal study, nt157 was found to suppress androgen-responsive growth, delay crpc progression of lncap xenografts, and suppress pc3 tumor growth alone or in combination with docetaxel. this study reported the first preclinical proof-of-principle data that nt157 suppressed irs1/2 expression, delayed crpc progression, and suppressed growth of crpc tumors in vivo [1].

IC 50

0.3 to 0.8 μm

References

[1] ibuki n et al. the tyrphostin nt157 suppresses insulin receptor substrates and augments therapeutic response of prostate cancer. mol cancer ther. 2014 dec;13(12):2827-39.

(E)-3-(3-bromo-4,5-dihydroxyphenyl)-N-(3,4,5-trihydroxybenzyl)prop-2-enethioamide Preparation Products And Raw materials

Raw materials

Preparation Products

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(E)-3-(3-bromo-4,5-dihydroxyphenyl)-N-(3,4,5-trihydroxybenzyl)prop-2-enethioamide Suppliers

China 58 India 2 Japan 1 The Netherlands 1 United States 8 Global 70
Axon Medchem BV
Tel
--
Fax
--
Email
info@axonmedchem.com
Country
The Netherlands
ProdList
477
Advantage
30
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View Lastest Price from (E)-3-(3-bromo-4,5-dihydroxyphenyl)-N-(3,4,5-trihydroxybenzyl)prop-2-enethioamide manufacturers

Career Henan Chemical Co
Product
(E)-3-(3-bromo-4,5-dihydroxyphenyl)-N-(3,4,5-trihydroxybenzyl)prop-2-enethioamide 1384426-12-3
Price
US $1.00/g
Min. Order
1g
Purity
99%
Supply Ability
200kg
Release date
2019-12-25

1384426-12-3, (E)-3-(3-bromo-4,5-dihydroxyphenyl)-N-(3,4,5-trihydroxybenzyl)prop-2-enethioamideRelated Search:


  • (E)-3-(3-bromo-4,5-dihydroxyphenyl)-N-(3,4,5-trihydroxybenzyl)prop-2-enethioamide
  • (2E)-3-(3-Bromo-4,5-dihydroxyphenyl)-N-[(3,4,5-trihydroxyphenyl)methyl]-2-propenethioamide
  • AK174915
  • AKOS025404921
  • CS-5531
  • NT-157
  • NT-157;NT 157;TYRPHOSTIN NT157
  • Tyrphostin NT157
  • CS-2283
  • NT157;NT 157
  • NT-157; NT 157; NT157.
  • 2-Propenethioamide, 3-(3-bromo-4,5-dihydroxyphenyl)-N-[(3,4,5-trihydroxyphenyl)methyl]-, (2E)-
  • NT 157 (This product is only available in Japan.)
  • 1384426-12-3