(E)-3-(3-bromo-4,5-dihydroxyphenyl)-N-(3,4,5-trihydroxybenzyl)prop-2-enethioamide

Product Name: (E)-3-(3-bromo-4,5-dihydroxyphenyl)-N-(3,4,5-trihydroxybenzyl)prop-2-enethioamide
CAS No.: 1384426-12-3
Chemical Name: (E)-3-(3-bromo-4,5-dihydroxyphenyl)-N-(3,4,5-trihydroxybenzyl)prop-2-enethioamide
Synonyms: NT-157;CS-2283;CS-5531;AK174915;NT157;NT 157;AKOS025404921;Tyrphostin NT157;NT-157; NT 157; NT157.;NT-157;NT 157;TYRPHOSTIN NT157;NT 157 (This product is only available in Japan.)
CBNumber: CB72745054
Molecular Formula: C16H14BrNO5S
Formula Weight: 412.26
MOL File: 1384426-12-3.mol

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(E)-3-(3-bromo-4,5-dihydroxyphenyl)-N-(3,4,5-trihydroxybenzyl)prop-2-enethioamide Property

Boiling point:: 660.3±65.0 °C(Predicted)
Density: 1.794±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: insoluble in H2O; ≥21.5 mg/mL in EtOH; ≥50 mg/mL in DMSO
form: solid
pka: 8.06±0.36(Predicted)
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 23442
Product name: NT-157
Purity: ≥98%
Packaging: 1mg
Price: $39
Updated: 2021/12/16

Cayman Chemical

Product number: 23442
Product name: NT-157
Purity: ≥98%
Packaging: 5mg
Price: $176
Updated: 2021/12/16

Cayman Chemical

Product number: 23442
Product name: NT-157
Purity: ≥98%
Packaging: 10mg
Price: $312
Updated: 2021/12/16

Cayman Chemical

Product number: 23442
Product name: NT-157
Purity: ≥98%
Packaging: 25mg
Price: $595
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb573093
Product name: NT-157
Purity: >98%
Packaging: 100mg
Price: $838.1
Updated: 2021/12/16

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(E)-3-(3-bromo-4,5-dihydroxyphenyl)-N-(3,4,5-trihydroxybenzyl)prop-2-enethioamide Chemical Properties,Usage,Production

Biological Activity

nt157 is an irs-1/2 inhibitor.insulin receptor substrates 1 and 2 (irs1/2) mediate antiapoptotic and mitogenic signaling from insulin receptor (ir), insulin-like growth factor 1 receptor (igf-ir), and other oncoproteins. irs1 plays a critical role in cancer cell proliferation, and its expression is increased in many human malignancies.

in vitro

nt157 treatment was fonund to be able to lead to dose-dependent suppression of irs protein expression, inhibition of igf1r activation, inhibition of igf1-induced akt activation, but increased erk activation in nt157-treated cells. these effects were associated with decreased proliferation, increased apoptosis of lncap cells and increased g2-m arrest in pc3 cells. moreover, nt157 could significantly affect the cell migratory ability, as demonstrated by a wound-healing assay. in addition, the nt157 treatment was able to induce cell cycle arrest and inhibit igf system signaling [1].

in vivo

in previous animal study, nt157 was found to suppress androgen-responsive growth, delay crpc progression of lncap xenografts, and suppress pc3 tumor growth alone or in combination with docetaxel. this study reported the first preclinical proof-of-principle data that nt157 suppressed irs1/2 expression, delayed crpc progression, and suppressed growth of crpc tumors in vivo [1].

IC 50

0.3 to 0.8 μm

References

[1] ibuki n et al. the tyrphostin nt157 suppresses insulin receptor substrates and augments therapeutic response of prostate cancer. mol cancer ther. 2014 dec;13(12):2827-39.

(E)-3-(3-bromo-4,5-dihydroxyphenyl)-N-(3,4,5-trihydroxybenzyl)prop-2-enethioamide Preparation Products And Raw materials

Raw materials

Preparation Products

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(E)-3-(3-bromo-4,5-dihydroxyphenyl)-N-(3,4,5-trihydroxybenzyl)prop-2-enethioamide Suppliers

China 58 India 2 Japan 1 The Netherlands 1 United States 8 Global 70

Musechem

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TargetMol Chemicals Inc.

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Aladdin Scientific

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TargetMol Chemicals Inc.

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Cayman Chemical Company

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ProdList: 6213
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View Lastest Price from (E)-3-(3-bromo-4,5-dihydroxyphenyl)-N-(3,4,5-trihydroxybenzyl)prop-2-enethioamide manufacturers

Career Henan Chemical Co

Product: (E)-3-(3-bromo-4,5-dihydroxyphenyl)-N-(3,4,5-trihydroxybenzyl)prop-2-enethioamide 1384426-12-3
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 200kg
Release date: 2019-12-25

1384426-12-3, (E)-3-(3-bromo-4,5-dihydroxyphenyl)-N-(3,4,5-trihydroxybenzyl)prop-2-enethioamideRelated Search:

(E)-3-(3-bromo-4,5-dihydroxyphenyl)-N-(3,4,5-trihydroxybenzyl)prop-2-enethioamide

(2E)-3-(3-Bromo-4,5-dihydroxyphenyl)-N-[(3,4,5-trihydroxyphenyl)methyl]-2-propenethioamide

AK174915

AKOS025404921

CS-5531

NT-157

NT-157;NT 157;TYRPHOSTIN NT157

Tyrphostin NT157

CS-2283

NT157;NT 157

NT-157; NT 157; NT157.

2-Propenethioamide, 3-(3-bromo-4,5-dihydroxyphenyl)-N-[(3,4,5-trihydroxyphenyl)methyl]-, (2E)-

NT 157 (This product is only available in Japan.)

1384426-12-3