2-(3-(methoxycarbonyl)phenyl)acetic acid
- Product Name
- 2-(3-(methoxycarbonyl)phenyl)acetic acid
- CAS No.
- 52787-19-6
- Chemical Name
- 2-(3-(methoxycarbonyl)phenyl)acetic acid
- Synonyms
- [3-(Methoxycarbonyl)phenyl]acetic acid;Benzeneacetic acid, 3-(methoxycarbonyl)-;2-(3-(methoxycarbonyl)phenyl)acetic acid
- CBNumber
- CB72745443
- Molecular Formula
- C10H10O4
- Formula Weight
- 194.18
- MOL File
- 52787-19-6.mol
2-(3-(methoxycarbonyl)phenyl)acetic acid Property
- Melting point:
- 83-84 °C
- Boiling point:
- 350.8±25.0 °C(Predicted)
- Density
- 1.254±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 4.17±0.10(Predicted)
- Appearance
- White to yellow Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- M342608
- Product name
- 2-(3-(Methoxycarbonyl)phenyl)aceticAcid
- Packaging
- 10mg
- Price
- $90
- Updated
- 2021/12/16
- Product number
- CS-0059794
- Product name
- 2-(3-(Methoxycarbonyl)phenyl)aceticacid
- Purity
- ≥97.0%
- Packaging
- 50mg
- Price
- $70
- Updated
- 2021/12/16
- Product number
- CS-0059794
- Product name
- 2-(3-(Methoxycarbonyl)phenyl)aceticacid
- Purity
- ≥97.0%
- Packaging
- 100mg
- Price
- $105
- Updated
- 2021/12/16
- Product number
- CS-0059794
- Product name
- 2-(3-(Methoxycarbonyl)phenyl)aceticacid
- Purity
- ≥97.0%
- Packaging
- 250mg
- Price
- $145
- Updated
- 2021/12/16
- Product number
- J97811
- Product name
- 2-[3-(Methoxycarbonyl)phenyl]aceticacid
- Packaging
- 250mg
- Price
- $154
- Updated
- 2021/12/16
2-(3-(methoxycarbonyl)phenyl)acetic acid Chemical Properties,Usage,Production
Synthesis
52787-20-9
52787-19-6
Methyl 3-(methoxycarbonyl)benzoate 76 (500 mg, 2.40 mmol) was used as a raw material and dissolved in methanol (10 mL). To this solution was added a solution of K2CO3 (700 mg, 5.07 mmol) in water (10 mL) and the reaction was stirred overnight at room temperature. Upon completion of the reaction, the reaction mixture was concentrated and dissolved in water (20 mL). Subsequently, the unreacted diester 76 was extracted with water and EtOAc, and the aqueous phase was acidified with 1N HCl and then extracted with EtOAc (30 mL x 2). The organic layers were combined, dried with anhydrous sodium sulfate and concentrated in vacuum. The crude product was purified by silica gel column chromatography (eluent: hexane/EtOAc, 5:1) to afford the target product 2-(3-(methoxycarbonyl)phenyl)acetic acid 77 (508 mg, 90% yield). The product was detected by TLC (Rf = 0.36), 1H NMR (400 MHz, methanol-d4) δ 7.97 (d, J = 1.7 Hz, 1H), 7.91 (dt, J = 7.8,1.4 Hz, 1H), 7.57-7.49 (m, 1H), 7.43 (t, J = 7.6 Hz, 1H), 3.91 (s, 3H), and 3.67 (s, 2H); mass spectral analysis showed [M + H]+ = 195.14 (APCI+).
References
[1] Patent: WO2013/52110, 2013, A1. Location in patent: Page/Page column 63; 65
[2] Journal of the Indian Chemical Society, 1987, vol. 64, # 1, p. 34 - 37
[3] Chimica Therapeutica, 1973, vol. 8, # 4, p. 487 - 494
2-(3-(methoxycarbonyl)phenyl)acetic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-(3-(methoxycarbonyl)phenyl)acetic acid manufacturers
- Product
- 2-(3-(methoxycarbonyl)phenyl)acetic acid 52787-19-6
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2020-01-08