RG3039

Product Name: RG3039
CAS No.: 1005504-62-0
Chemical Name: RG3039
Synonyms: RG3039;CS-2207;EOS-62326;EOS-61154;PF-6687859;PF-6687859 Free;RG-3039; RG3039;RG3039(PF-06687859);PF-06687859/R -3039;Rg3039, 10 mM in DMSO
CBNumber: CB72745524
Molecular Formula: C21H23Cl2N5O
Formula Weight: 432.35
MOL File: 1005504-62-0.mol

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RG3039 Property

Boiling point:: 648.1±65.0 °C(Predicted)
Density: 1.375±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO:2.0(Max Conc. mg/mL);4.6(Max Conc. mM)
form: A solid
pka: 7.82±0.30(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

DC Chemicals

Product number: DC7551
Product name: RG3039(PF-06687859)
Purity: >98%
Packaging: 100mg
Price: $500
Updated: 2021/12/16

Crysdot

Product number: CD11369359
Product name: RG3039(PF-06687859)
Purity: 95+%
Packaging: 100mg
Price: $520
Updated: 2021/12/16

DC Chemicals

Product number: DC7551
Product name: RG3039(PF-06687859)
Purity: >98%
Packaging: 250mg
Price: $1000
Updated: 2021/12/16

DC Chemicals

Product number: DC7551
Product name: RG3039(PF-06687859)
Purity: >98%
Packaging: 1g
Price: $2000
Updated: 2021/12/16

Crysdot

Product number: CD11369359
Product name: RG3039(PF-06687859)
Purity: 95+%
Packaging: 1g
Price: $2080
Updated: 2021/12/16

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RG3039 Chemical Properties,Usage,Production

Biological Activity

RG3039 is a brain-penetrant and potent inhibitor against the scavenger mRNA-decapping enzyme DcpS (m7GpppX diphosphatase) in vitro (mouse DcpS IC50 = 3.4 nM) and in mice in vivo (∼90% & ∼80% inhibition of brain DcpS, respectively, 2 h & 72 h post last 3 mg/kg daily ip. from P1 to P10). In a murine severe spinal muscular atrophy (SMA) model, RG3039 (10-20 mg/kg/d ip. from P1 till death) increases SMAΔ7 mice survival (by 26%) and motor function with a ∼50% increase of VGLUT1 synapses number on L3-L5 motor neurons (33.7/WT mice at P13 vs. 17.2/SMA mice without 26.1/SMA mice with RG3039 treatment).

RG3039 Preparation Products And Raw materials

Raw materials

Preparation Products

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RG3039 Suppliers

China 55 United States 8 Global 63

Shanghai Boyle Chemical Co., Ltd.

Tel
Fax: 86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2922
Advantage: 55

MedChemexpress LLC

Tel: 021-58955995
Fax: 609-228-5909
Email: sales@medchemexpress.cn
Country: United States
ProdList: 4861
Advantage: 58

AdooQ Bioscience CHINA

Tel: 025-58849295 18951903616;
Fax: 025-68650336
Email: info@adooq.cn
Country: China
ProdList: 2990
Advantage: 60

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4599
Advantage: 55

Nanjing Chempioneer Pharmaceutical Co., Ltd.

Tel: 18068075658
Fax: -
Email: sales@chempioneer.com
Country: China
ProdList: 1811
Advantage: 58

Wuhu Nuowei Chemical Technology Co., Ltd

Tel: 0553-8233716-803 18055311600
Email: sales@nuowei-chem.com
Country: China
ProdList: 951
Advantage: 55

Tianjin Kailiqi Biotechnology Co., Ltd.

Tel: 15076683720
Fax: 022-23754520
Email: klq@cw-bio.com
Country: China
ProdList: 6015
Advantage: 55

Jinan elephant international trading co., LTD

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Fax: -
Email: 13006575422@163.com
Country: China
ProdList: 6355
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Shanghai Chaolan Chemical Technology Center

Tel: 021-QQ：65489617 15618227136
Fax: 21-5161 9052
Email: Sales@ATKchemical.com
Country: China
ProdList: 9014
Advantage: 58

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

1005504-62-0, RG3039Related Search:

Xylene

RG3039

RG3039(PF-06687859)

5-[[1-(2,6-Dichlorobenzyl)piperidin-4-yl]methoxy]quinazoline-2,4-diamine

5-((1-(2,6-dichlorobenzyl)piperidin-4-yl)methoxy)quinazoline-2,4-diaminedihydrochloride

PF-6687859

EOS-61154

EOS-62326

RG-3039; RG3039

CS-2207

2,4-Quinazolinediamine, 5-[[1-[(2,6-dichlorophenyl)methyl]-4-piperidinyl]methoxy]-

PF-6687859 Free

PF06687859,Inhibitor,PF 06687859,inhibit,Rg-3039,RG 3039,Rg3039

PF-06687859/R -3039

Rg3039, 10 mM in DMSO

1005504-62-0