ChemicalBook > CAS DataBase List > CB5083
CB5083
- Product Name
- CB5083
- CAS No.
- 1542705-92-9
- Chemical Name
- CB5083
- Synonyms
- CB5083;CS-1553;CB-5083;EOS-61078;CB 5083;CB5083;CB5083; CB-5083; CB 5083.;1-[4-(benzylamino)-5H,7H,8H-pyrano[4,3-d]pyrimidin-2-yl]-2-methyl-1H-indole-4-carboxamide;1-[4-(benzylamino)-7,8-dihydro-5H-pyrano[4,3-d]pyrimidin-2-yl]-2-methylindole-4-carboxamide;1-(4-(benzylamino)-7,8-dihydro-5H-pyrano[4,3-d]pyrimidin-2-yl)-2-methyl-1H-indole-4-carboxamide;1H-Indole-4-carboxamide, 1-[7,8-dihydro-4-[(phenylmethyl)amino]-5H-pyrano[4,3-d]pyrimidin-2-yl]-2-methyl-
- CBNumber
- CB72749007
- Molecular Formula
- C24H23N5O2
- Formula Weight
- 413.47
- MOL File
- 1542705-92-9.mol
More
Less
CB5083 Property
- Boiling point:
- 760.5±70.0 °C(Predicted)
- Density
- 1.37±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- insoluble in H2O; ≥20.65 mg/mL in DMSO; ≥4.4 mg/mL in EtOH
- form
- solid
- pka
- 15.99±0.30(Predicted)
More
Less
N-Bromosuccinimide Price
Cayman Chemical
- Product number
- 19311
- Product name
- CB-5083
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $44
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 19311
- Product name
- CB-5083
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $132
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 19311
- Product name
- CB-5083
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $242
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 19311
- Product name
- CB-5083
- Purity
- ≥95%
- Packaging
- 25mg
- Price
- $548
- Updated
- 2024/03/01
Biosynth Carbosynth
- Product number
- BC177445
- Product name
- CB 5083 NEW
- Packaging
- 25mg
- Price
- $550
- Updated
- 2021/12/16
More
Less
CB5083 Chemical Properties,Usage,Production
Biological Activity
cb-5083 is an orally bioavailable inhibitor of p97. p97 is an aaa-atpase involved in multiple cellular functions such as organelle membrane homotypic fusion and sorting of endosomal cargo. p97 is also known as valosin-containing protein which plays important roles in regulating protein homeostasis [1].
in vitro
cb-5083 is a selective potent inhibitor of p97’s second atpase domain. cb-5083 might compete with atp for the same binding site but may adopt a different orientation[2]. the ic50 of cb-5083 against wild-type (wt) p97 was 15.4 nm. cb-5083 could dose-dependently increase the cytosolic protein degradation in hek293t, a549 and hct116 cell lines [1]. cb-5083 treatment (2.5 μm) of a549 cells for 24h could induce cancer cell death [1].
in vivo
in female nude mice bearing hct116, a549 lung carcinoma, and amo-1 multiple myeloma xenograft tumors, oral administration of cb-5083 (100 mg/kg) for 6 h showed a significant antitumor response in tumors (tgi = 63%, p < 0.0001) [1,2].
IC 50
15.4 nm
storage
Store at -20°C
References
anderson d j, le moigne r, djakovic s, et al. targeting the aaa atpase p97 as an approach to treat cancer through disruption of protein homeostasis[j]. cancer cell, 2015, 28(5): 653-665.zhou h j, wang j, yao b, et al. discovery of a first-in-class, potent, selective, and orally bioavailable inhibitor of the p97 aaa atpase (cb-5083)[j]. journal of medicinal chemistry, 2015, 58(24): 9480-9497.
CB5083 Preparation Products And Raw materials
Raw materials
Preparation Products
More
Less
CB5083 Suppliers
- Tel
- 2717893647 14768611851
- 486064515@qq.com
- Country
- China
- ProdList
- 1414
- Advantage
- 58
- Tel
- Fax
- 86-21-57758967
- sales@boylechem.com
- Country
- China
- ProdList
- 2923
- Advantage
- 55
- Tel
- 17702719238 17702719238
- sales@sun-shinechem.com
- Country
- China
- ProdList
- 918
- Advantage
- 64
- Tel
- 0411-62910999 13889544652
- sales@meilune.com
- Country
- China
- ProdList
- 4663
- Advantage
- 58
- Tel
- 18993966060
- Fax
- 0943-8288977
- sales@techbiochem.com
- Country
- China
- ProdList
- 932
- Advantage
- 61
- Tel
- 18017383231 18017383231
- Fax
- qq：2817624287
- lyh_antaeus@163.com
- Country
- China
- ProdList
- 9352
- Advantage
- 55
- Tel
- 021-58950125
- Fax
- (86) 21-58955996
- info@chemexpress.com
- Country
- China
- ProdList
- 7553
- Advantage
- 61
- Tel
- 021-021-33632979 15002134094
- Fax
- 021-33632979
- marketing@targetmol.com
- Country
- China
- ProdList
- 7854
- Advantage
- 58
- Tel
- 021-57646680 18306277365
- Fax
- 2469917557
- sunkai@chembiobanksh.com
- Country
- China
- ProdList
- 2048
- Advantage
- 55
- Tel
- 025-58849295 18951903616;
- Fax
- 025-68650336
- info@adooq.cn
- Country
- China
- ProdList
- 2989
- Advantage
- 60
- Tel
- 021-52996696，15000506266 15000506266
- Fax
- +86-21-52996696
- Country
- China
- ProdList
- 4182
- Advantage
- 55
- Tel
- 021-61350663 13052117465
- Fax
- 021-61350662
- sales@zehanbiopharma.com
- Country
- China
- ProdList
- 990
- Advantage
- 55
- Tel
- +86-21-58447131
- Fax
- +86-21-61642470
- 1724405207@qq.com
- Country
- China
- ProdList
- 472
- Advantage
- 55
- Tel
- Fax
- -
- eric_feng1954@126.com
- Country
- China
- ProdList
- 9254
- Advantage
- 55
- Tel
- 010-15313962280 15313962280
- Fax
- 010-51669040
- 3004509780@qq.com
- Country
- China
- ProdList
- 818
- Advantage
- 55
- Tel
- +86-400-851-9921
- Fax
- +86-10-82826195
- sales@pharmacodia.com
- Country
- China
- ProdList
- 2317
- Advantage
- 55
- Tel
- 02781293128
- orders@biochemsafebuy.com
- Country
- China
- ProdList
- 9934
- Advantage
- 55
- Tel
- 021-021-20242659 18930833303
- Fax
- +86 (21) 2024-2659
- order@changyanchem.com
- Country
- China
- ProdList
- 5008
- Advantage
- 55
- Tel
- 17754423994 17754423994
- Fax
- QQ:2853530913
- 2853530910@QQ.com
- Country
- China
- ProdList
- 8010
- Advantage
- 62
- Tel
- 21-31433387 15618786686
- Fax
- QQ:1369748377
- sales@rechemscience.com
- Country
- China
- ProdList
- 2986
- Advantage
- 58
- Tel
- Fax
- -
- 13006575422@163.com
- Country
- China
- ProdList
- 6357
- Advantage
- 58
- Tel
- QQ:65489617 15618227136
- Fax
- 21-5161 9052
- info@SuperLan-chem.com
- Country
- China
- ProdList
- 9824
- Advantage
- 58
- Tel
- 010-50973130 4009686088
- 3193328036@qq.com
- Country
- China
- ProdList
- 29796
- Advantage
- 68
- Tel
- 571-89925085
- Fax
- 0086-571-89925065
- sales@amadischem.com
- Country
- China
- ProdList
- 131980
- Advantage
- 58
- Tel
- +86-13168912896
- Country
- China
- ProdList
- 253
- Advantage
- 58
- Tel
- 0519-83246372 13585352506
- Fax
- 0519-83246372
- Country
- China
- ProdList
- 1844
- Advantage
- 58
- Tel
- 0550-5196001 15000891977
- Fax
- 0550-5196001
- wj520wjxby@126.com
- Country
- China
- ProdList
- 1836
- Advantage
- 55
- Tel
- 010-88886666-01 13112345678
- Fax
- CDXH21@126.com
- loyson@tcypharm.com
- Country
- China
- ProdList
- 595
- Advantage
- 55
- Tel
- +86 18721201413
- Fax
- +86 (21) 5775-8967
- sales@biopharmaleader.com
- Country
- China
- ProdList
- 1720
- Advantage
- 58
- Tel
- +86-027-6552-2453
- sales@sun-shinechem.com
- Country
- China
- ProdList
- 727
- Advantage
- 58
- Tel
- Fax
- -
- jnyaoyan@163.com
- Country
- China
- ProdList
- 3069
- Advantage
- 58
- Tel
- 17317130613
- Fax
- QQ3358272972
- 3358272972@qq.com
- Country
- China
- ProdList
- 3245
- Advantage
- 58
- Tel
- 021000000
- admin@jingshipharmatech.com
- Country
- China
- ProdList
- 10073
- Advantage
- 58
- Tel
- 400-400-400-9004166 18616739031
- 3007523370@qq.com
- Country
- China
- ProdList
- 52712
- Advantage
- 58
- Tel
- 020-31155029 18902330969
- Fax
- 020-31155029
- sales@tomums.cn
- Country
- China
- ProdList
- 4698
- Advantage
- 58
- Tel
- 0576-88813233 13396860566
- sales@pharm-intermediates.com
- Country
- China
- ProdList
- 2013
- Advantage
- 58
- Tel
- zhiqianbio@126.com
- Country
- China
- ProdList
- 19785
- Advantage
- 58
- Tel
- meitaochem@126.com
- meitaochem@126.com
- Country
- China
- ProdList
- 19105
- Advantage
- 58
- Tel
- +1-2135480471 +1-2135480471
- sales@sarms4muscle.com
- Country
- China
- ProdList
- 10523
- Advantage
- 58
- Tel
- 86-571-88216897,88216896 13588875226
- Fax
- 86-571-88216895
- sales@hzclap.com
- Country
- CHINA
- ProdList
- 6313
- Advantage
- 58
- Tel
- 15608644787
- 13872128609@163.com
- Country
- CHINA
- ProdList
- 96
- Advantage
- 58
- Tel
- 021-58447131 13564518121
- sales@dcchemicals.com
- Country
- China
- ProdList
- 9414
- Advantage
- 58
- Tel
- 0519-85788828 13775037613
- sales@chemrenpharm.com
- Country
- China
- ProdList
- 3574
- Advantage
- 58
- Tel
- 13969155946
- 1461866103@qq.com
- Country
- China
- ProdList
- 16111
- Advantage
- 58
- Tel
- 18818260767
- Fax
- QQ 3610331285
- sales@chemegen.com
- Country
- China
- ProdList
- 11289
- Advantage
- 58
- Tel
- 021-61998551 13122364865
- sale1@shzysw.net
- Country
- China
- ProdList
- 9771
- Advantage
- 58
- Tel
- 020-020-82000279 18988968278
- Fax
- QQ：3283937693
- sales@ubiochem.com
- Country
- China
- ProdList
- 2435
- Advantage
- 58
- Tel
- 021-38015121 15000105423
- chenjw@absin.cn
- Country
- China
- ProdList
- 24734
- Advantage
- 58
- Tel
- 88888888888
- hongquchem@qq.com
- Country
- China
- ProdList
- 5132
- Advantage
- 58
- Tel
- 021-51111890 15317326293
- sales@molnova.com
- Country
- China
- ProdList
- 4196
- Advantage
- 58