2-(7-Fluoropyrrolo[1,2-a]quinoxalin-4-yl)hydrazide-2-pyrazinecarboxylic acid hydrochloride
- Product Name
- 2-(7-Fluoropyrrolo[1,2-a]quinoxalin-4-yl)hydrazide-2-pyrazinecarboxylic acid hydrochloride
- CAS No.
- 917497-70-2
- Chemical Name
- 2-(7-Fluoropyrrolo[1,2-a]quinoxalin-4-yl)hydrazide-2-pyrazinecarboxylic acid hydrochloride
- Synonyms
- CS-2091;SC144 HCl;SC144 hydrochloride;N'-(7-fluoropyrrolo[1,2-a]quinoxalin-4-yl)pyrazine-2-carbohydrazide;N’-(7-Fluoropyrrolo[1,2-a]quinoxalin-4-yl)pyrazine-2-carbohydrazide Hydrochloride;2-(7-Fluoropyrrolo[1,2-a]quinoxalin-4-yl)hydrazide-2-pyrazinecarboxylic acid hydrochloride;2-(7-Fluoropyrrolo[1,2-a]quinoxalin-4-yl) 2-pyrazinecarboxylic acid hydrazide hydrochloride
- CBNumber
- CB72750597
- Molecular Formula
- C17H12ClFN6O3
- Formula Weight
- 402.7669832
- MOL File
- 917497-70-2.mol
2-(7-Fluoropyrrolo[1,2-a]quinoxalin-4-yl)hydrazide-2-pyrazinecarboxylic acid hydrochloride Property
- Melting point:
- 282 °C (decomp)(Solv: methanol (67-56-1))
- storage temp.
- -20°C
- solubility
- DMSO: soluble5mg/mL, clear (warmed)
- form
- powder
- color
- white to light brown
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- SML0763
- Product name
- SC144 hydrochloride
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $85.4
- Updated
- 2025/07/31
- Product number
- SML0763
- Product name
- SC144 hydrochloride
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $364
- Updated
- 2025/07/31
- Product number
- 29714
- Product name
- SC144 (hydrochloride)
- Packaging
- 5mg
- Price
- $116
- Updated
- 2024/03/01
- Product number
- 29714
- Product name
- SC144 (hydrochloride)
- Packaging
- 25mg
- Price
- $456
- Updated
- 2024/03/01
- Product number
- 29714
- Product name
- SC144 (hydrochloride)
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
2-(7-Fluoropyrrolo[1,2-a]quinoxalin-4-yl)hydrazide-2-pyrazinecarboxylic acid hydrochloride Chemical Properties,Usage,Production
Description
SC144 is an orally bioavailable gp130 inhibitor. It inhibits phosphorylation of STAT1, STAT3, and Akt induced by leukemia inhibitory factor (LIF) and IL-6, but not IFN-γ, in OVCAR-8 ovarian cancer cells when used at a concentration of 20 μM. SC144 induces cell cycle arrest at the G0/G1 phase in MDA-MB-435 breast and HT-29 colorectal cancer cells and inhibits proliferation of 14 cancer cell lines, including prostate, ovarian, lung, breast, and colorectal cancer cells, with IC50 values ranging from 0.4 to 4 μM. It reduces tumor growth in OVCAR-8 and MDA-MB-435 mouse xenograft models.
Uses
SC144 hydrochloride has been used:
- as a glycoprotein 130 (gp130) inhibitor to evaluate the effect of bazedoxifene on interleukin (IL-6) mediated cell viability in pancreatic cancer cells
- as a gp130 inhibitor to study its effects on signal transducer and activator of transcription 3 (STAT3) activation in mesenchymal precursor?cells?(KMM)?cells
- as an interleukin 6 signal transducer (IL-6ST) inhibitor in media to test its ability to block serum-induced migration/invasion
Uses
SC 144 Hydrochloride has been shown to have antitumor properties.
Biochem/physiol Actions
SC144 is a potent inhibitor of glycoprotein 130 (gp130). SC144 binds to gp130 and blocks STAT3 phosphorylation, nuclear translocation and expression of STAT3 responsive genes. SC144 inhibits the growth of several tumor cell lines, independent of p53 or hormone receptor levels, and inhibits growth of ovarain tumor xenografts in mice.
in vivo
SC144 (10 mg/kg; i.p.; daily for 58 days) suppresses tumor growth in human ovariancancer xenografts[1].
SC144 (100 mg/kg; p.o.; daily for 35 days) treatment shows the average tumor volume in mice 82% smaller than that in the control group[1].
| Animal Model: | Athymic mice (human ovarian cancer xenograft)[1] |
| Dosage: | I.p; daily for 58 days |
| Administration: | 10 mg/kg |
| Result: | Significantly inhibited tumor growth by about 73%. |
IC 50
IL6-beta
storage
Store at -20°C
References
[1] SHILI XU. Discovery of a novel orally active small-molecule gp130 inhibitor for the treatment of ovarian cancer.[J]. Molecular Cancer Therapeutics, 2013: 937-949. DOI: 10.1158/1535-7163.mct-12-1082
[2] CARMEN PLASENCIA. Discovery of a novel quinoxalinhydrazide with a broad-spectrum anticancer activity.[J]. Cancer Biology & Therapy, 2009, 8 5: 458-465. DOI: 10.4161/cbt.8.5.7741
2-(7-Fluoropyrrolo[1,2-a]quinoxalin-4-yl)hydrazide-2-pyrazinecarboxylic acid hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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