(T-4)-[(1E,6E)-1,7-bis[4-(Dimethylamino)phenyl]-1,6-heptadiene-3,5-dionato-O3,O5]difluoroboron

Product Name: (T-4)-[(1E,6E)-1,7-bis[4-(Dimethylamino)phenyl]-1,6-heptadiene-3,5-dionato-O3,O5]difluoroboron
CAS No.: 1193447-34-5
Chemical Name: (T-4)-[(1E,6E)-1,7-bis[4-(Dimethylamino)phenyl]-1,6-heptadiene-3,5-dionato-O3,O5]difluoroboron
Synonyms: CRANAD 2;CRANAD 2[SML0842];CRANAD-2, Near-infrared Amyloid-beta fluorescent probe;inhibit,CRANAD-2,CRANAD 2,CRANAD2,Abeta,Amyloid-β,β-amyloid peptide,Inhibitor;4,6-bis(4-dimethylaminophenyl styryl)- 2,2-difluoro-(1,3,2) dioxaborinin-4-ene-1-ium-2-uide;(T-4)-[(1E,6E)-1,7-bis[4-(Dimethylamino)phenyl]-1,6-heptadiene-3,5-dionato-?O3,?O5]difluoroboron;(T-4)-[(1E,6E)-1,7-Bis[4-(dimethylamino)phenyl]-1,6-heptadiene-3,5-dionato-kO3,kO5]difluoroboron;(T -4)-[(1E ,6E )-1,7-Bis[4-(dimethylamino) phenyl]-1,6-heptadiene-3,5-dionato-κO ,κO ] difluoroboron;Boron, [(1E,6E)-1,7-bis[4-(dimethylamino)phenyl]-1,6-heptadiene-3,5-dionato-κO3,κO5]difluoro-, (T-4)- (ACI)
CBNumber: CB72750603
Molecular Formula: C23H25BF2N2O2
Formula Weight: 410.2646064
MOL File: 1193447-34-5.mol

More

Less

(T-4)-[(1E,6E)-1,7-bis[4-(Dimethylamino)phenyl]-1,6-heptadiene-3,5-dionato-O3,O5]difluoroboron Property

storage temp.: 2-8°C
solubility: DMSO: soluble0.2mg/mL, clear (warmed)
form: powder
color: dark blue to black
InChI: 1S/C23H25BF2N2O2/c1-27(2)20-11-5-18(6-12-20)9-15-22-17-23(30-24(25,26)29-22)16-10-19-7-13-21(14-8-19)28(3)4/h5-17H,1-4H3/b15-9+,16-10+
InChIKey: PVXQJYXODFZTBR-KAVGSWPWSA-N
SMILES: [B-]1([O+]=C(C=C(O1)\C=C\c3ccc(cc3)N(C)C)\C=C\c2ccc(cc2)N(C)C)(F)F

More

Less

Safety

Hazard Codes: Xi
Risk Statements: 36/38
Safety Statements: 26
WGK Germany: 3
Storage Class: 11 - Combustible Solids
Hazard Classifications: Eye Irrit. 2
Skin Irrit. 2

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0842
Product name: CRANAD 2
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $135
Updated: 2026/03/19

Sigma-Aldrich

Product number: SML0842
Product name: CRANAD 2
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $527
Updated: 2026/03/19

Cayman Chemical

Product number: 19814
Product name: CRANAD 2
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 19814
Product name: CRANAD 2
Purity: ≥98%
Packaging: 5mg
Price: $93
Updated: 2024/03/01

Cayman Chemical

Product number: 19814
Product name: CRANAD 2
Purity: ≥98%
Packaging: 10mg
Price: $153
Updated: 2024/03/01

More

Less

(T-4)-[(1E,6E)-1,7-bis[4-(Dimethylamino)phenyl]-1,6-heptadiene-3,5-dionato-O3,O5]difluoroboron Chemical Properties,Usage,Production

Uses

CRANAD 2 is a near-infrared probe that binds to Aβ40 aggregates and elicits an emission blue shift. It was shown to bind to plaques in APP-PS1 transgenic mice, in vitro.

Biological Activity

CRANAD 2 is a near-infrared (NIR) Aβ plaque-specific fluorescent probe. CRANAD 2 penetrates the blood brain barrier and has a high affinity for Aβ aggregates with a Kd of 38 nM. Upon interacting with Aβ aggregates, CRANAD 2 exhibits a 70-fold increase in fluorescence intensity accompanied by a 90 nm blue shift from 805 to 715 nm and a large increase in quantum yield. CRANAD 2 has been used to detect Aβ deposits noninvasively in vivo in transgenic Tg2576 mice.

storage

Store at -20°C

(T-4)-[(1E,6E)-1,7-bis[4-(Dimethylamino)phenyl]-1,6-heptadiene-3,5-dionato-O3,O5]difluoroboron Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

(T-4)-[(1E,6E)-1,7-bis[4-(Dimethylamino)phenyl]-1,6-heptadiene-3,5-dionato-O3,O5]difluoroboron Suppliers

CHINA 80 India 1 United Kingdom 2 United States 7 Global 90

Olix (Shanghai) Pharmaceutical Technology Co., Ltd

Tel: 17316404525 17316404525
Email: 209533805@qq.com
Country: China
ProdList: 9804
Advantage: 58

Spectrum Chemical Manufacturing Corp.

Tel: 021-021-021-67601398-809-809-809 15221380277
Fax: 021-57711696
Email: marketing_china@spectrumchemical.com
Country: China
ProdList: 9658
Advantage: 60

Shanghai KaiYuLin pharmaceutical technology co., LTD

Tel: 021-18721936-595 18721936595
Fax: -
Email: shkylpharma@126.com
Country: China
ProdList: 747
Advantage: 55

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4827
Advantage: 55

Nanjing XiZe Biotechnology CO., Ltd.

Tel: 025-66023220 15250997978
Fax: 025-58362220
Email: 1511893459@qq.com
Country: China
ProdList: 4876
Advantage: 55

Pharmacodia (Beijing) Co.,Ltd

Tel: +86-400-851-9921
Fax: +86-10-82826195
Email: sales@pharmacodia.com
Country: China
ProdList: 2317
Advantage: 55

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9803
Advantage: 58

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 86249
Advantage: 60

ShangHai Biochempartner Co.,Ltd

Tel: 177-54423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 8000
Advantage: 62

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

1193447-34-5, (T-4)-[(1E,6E)-1,7-bis[4-(Dimethylamino)phenyl]-1,6-heptadiene-3,5-dionato-O3,O5]difluoroboronRelated Search:

(T-4)-[(1E,6E)-1,7-Bis[4-(dimethylamino)phenyl]-1,6-heptadiene-3,5-dionato-kO3,kO5]difluoroboron

(T-4)-[(1E,6E)-1,7-bis[4-(Dimethylamino)phenyl]-1,6-heptadiene-3,5-dionato-?O3,?O5]difluoroboron

CRANAD 2

4,6-bis(4-dimethylaminophenyl styryl)- 2,2-difluoro-(1,3,2) dioxaborinin-4-ene-1-ium-2-uide

Boron, [(1E,6E)-1,7-bis[4-(dimethylamino)phenyl]-1,6-heptadiene-3,5-dionato-κO3,κO5]difluoro-, (T-4)- (ACI)

inhibit,CRANAD-2,CRANAD 2,CRANAD2,Abeta,Amyloid-β,β-amyloid peptide,Inhibitor

(T -4)-[(1E ,6E )-1,7-Bis[4-(dimethylamino) phenyl]-1,6-heptadiene-3,5-dionato-κO ,κO ] difluoroboron

CRANAD-2, Near-infrared Amyloid-beta fluorescent probe

CRANAD 2[SML0842]

1193447-34-5

C23H25BF2N2O2