4′-[[2,3-Dimethyl-5-[[[(1S)-1-(4-nitrophenyl)ethyl]amino]carbonyl]-1H-indol-1-yl]methyl]- [1,1′-Biphenyl]-2-carboxylic acid

Product Name: 4′-[[2,3-Dimethyl-5-[[[(1S)-1-(4-nitrophenyl)ethyl]amino]carbonyl]-1H-indol-1-yl]methyl]- [1,1′-Biphenyl]-2-carboxylic acid
CAS No.: 1338259-05-4
Chemical Name: 4′-[[2,3-Dimethyl-5-[[[(1S)-1-(4-nitrophenyl)ethyl]amino]carbonyl]-1H-indol-1-yl]methyl]- [1,1′-Biphenyl]-2-carboxylic acid
Synonyms: SR1664;SR1664 >=98% (HPLC);SR1664, 10 mM in DMSO;IIJDFXNUWZTHIM-NRFANRHFSA-N;4′-[[2,3-Dimethyl-5-[[[(1S)-1-(4-nitrophenyl)ethyl]amino]carbonyl]-1H-indol-1-yl]methyl]- [1,1′-Biphenyl]-2-carboxylic acid;[1,1'-Biphenyl]-2-carboxylic acid, 4'-[[2,3-dimethyl-5-[[[(1S)-1-(4-nitrophenyl)ethyl]amino]carbonyl]-1H-indol-1-yl]methyl]-;Inhibitor,inhibit,HEK293T,F282,clash,SR1664,stereospecificity,PPAR,dependent,phosphorylation,SR-1664,S273,Peroxisome proliferator-activated receptors
CBNumber: CB72750678
Molecular Formula: C33H29N3O5
Formula Weight: 547.6
MOL File: 1338259-05-4.mol

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4′-[[2,3-Dimethyl-5-[[[(1S)-1-(4-nitrophenyl)ethyl]amino]carbonyl]-1H-indol-1-yl]methyl]- [1,1′-Biphenyl]-2-carboxylic acid Property

Boiling point:: 828.8±65.0 °C(Predicted)
Density: 1.27±0.1 g/cm3(Predicted)
storage temp.: -20°C
solubility: DMSO: soluble15mg/mL, clear
pka: 3.87±0.36(Predicted)
form: powder
color: white to beige

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Safety

Risk Statements: 53
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0636
Product name: SR1664
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $201
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML0636
Product name: SR1664
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $247.6
Updated: 2024/03/01

Cayman Chemical

Product number: 11086
Product name: SR 1664
Purity: ≥98%
Packaging: 1mg
Price: $45
Updated: 2024/03/01

Cayman Chemical

Product number: 11086
Product name: SR 1664
Purity: ≥98%
Packaging: 5mg
Price: $166
Updated: 2024/03/01

Cayman Chemical

Product number: 11086
Product name: SR 1664
Purity: ≥98%
Packaging: 10mg
Price: $220
Updated: 2024/03/01

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4′-[[2,3-Dimethyl-5-[[[(1S)-1-(4-nitrophenyl)ethyl]amino]carbonyl]-1H-indol-1-yl]methyl]- [1,1′-Biphenyl]-2-carboxylic acid Chemical Properties,Usage,Production

Uses

SR 1664 is a PPARγ non-agonist, which blocks Cdk5-mediated phosphorylation.

Definition

ChEBI: [1,1'-biphenyl]-2-carboxylic acid, 4'-[[2,3-dimethyl-5-[[[(1s)-1-(4-nitrophenyl)ethyl]amino]carbonyl]-1h-indol-1-yl]methyl]- is an indolecarboxamide.

Biological Activity

SR1664 is a non-agonist PPARγ ligand and an inhibitor of Cdk5-mediated PPARγ phosphorylation. It has strong antidiabetic activity in two murine models of diabetes without the side effects normally asociated with the thiazolidinedione (TZD) antidiabetic PPARγ agonists. The TZD antidiabetics such as rosiglitazone and pioglitazone are full PPARγ agonists, but recent data have suggested th at their separate activity, inhibition of the the obesity-linked PPARγ phosphorylation by Cdk5, is likely the more important activity for antidiabetic action. SR1664 has an IC50 of 80 nM in a competitive binding assay, blocked the Cdk5-mediated phosphorylation of PPARγ in vitro with IC50 between 20 and 200 nM and exhibited no PPARγ agonist activity.

4′-[[2,3-Dimethyl-5-[[[(1S)-1-(4-nitrophenyl)ethyl]amino]carbonyl]-1H-indol-1-yl]methyl]- [1,1′-Biphenyl]-2-carboxylic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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4′-[[2,3-Dimethyl-5-[[[(1S)-1-(4-nitrophenyl)ethyl]amino]carbonyl]-1H-indol-1-yl]methyl]- [1,1′-Biphenyl]-2-carboxylic acid Suppliers

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1338259-05-4, 4′-[[2,3-Dimethyl-5-[[[(1S)-1-(4-nitrophenyl)ethyl]amino]carbonyl]-1H-indol-1-yl]methyl]- [1,1′-Biphenyl]-2-carboxylic acidRelated Search:

4′-[[2,3-Dimethyl-5-[[[(1S)-1-(4-nitrophenyl)ethyl]amino]carbonyl]-1H-indol-1-yl]methyl]- [1,1′-Biphenyl]-2-carboxylic acid

SR1664

IIJDFXNUWZTHIM-NRFANRHFSA-N

[1,1'-Biphenyl]-2-carboxylic acid, 4'-[[2,3-dimethyl-5-[[[(1S)-1-(4-nitrophenyl)ethyl]amino]carbonyl]-1H-indol-1-yl]methyl]-

SR1664 >=98% (HPLC)

Inhibitor,inhibit,HEK293T,F282,clash,SR1664,stereospecificity,PPAR,dependent,phosphorylation,SR-1664,S273,Peroxisome proliferator-activated receptors

SR1664, 10 mM in DMSO

1338259-05-4