N-[5-(2-Furanyl)-1,3,4-oxadiazol-2-yl]-N′-(2-pyridinylmethyl)-urea

Product Name: N-[5-(2-Furanyl)-1,3,4-oxadiazol-2-yl]-N′-(2-pyridinylmethyl)-urea
CAS No.: 1414963-82-8
Chemical Name: N-[5-(2-Furanyl)-1,3,4-oxadiazol-2-yl]-N′-(2-pyridinylmethyl)-urea
Synonyms: NK 252;NK252;NK-252 >=98% (HPLC);NK-252,NK252,NK 252,inhibit,Inhibitor,Keap1-Nrf2;1-(5-(Furan-2-yl)-1,3,4-oxadiazol-2-yl)-3-(pyridin-2-ylmethyl)urea;N-[5-(2-Furanyl)-1,3,4-oxadiazol-2-yl]-N′-(2-pyridinylmethyl)-urea;Urea, N-[5-(2-furanyl)-1,3,4-oxadiazol-2-yl]-N'-(2-pyridinylmethyl)-
CBNumber: CB72750704
Molecular Formula: C13H11N5O3
Formula Weight: 285.26
MOL File: 1414963-82-8.mol

More

Less

N-[5-(2-Furanyl)-1,3,4-oxadiazol-2-yl]-N′-(2-pyridinylmethyl)-urea Property

Density: 1.408±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: soluble20mg/mL, clear
pka: 11.50±0.70(Predicted)
form: powder
color: white to beige

More

Less

Safety

Hazard Codes: Xn
Risk Statements: 22
WGK Germany: 3

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0944
Product name: NK-252
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $85.3
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML0944
Product name: NK-252
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $335
Updated: 2024/03/01

Cayman Chemical

Product number: 19131
Product name: NK 252
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 19131
Product name: NK 252
Purity: ≥98%
Packaging: 5mg
Price: $86
Updated: 2024/03/01

Cayman Chemical

Product number: 19131
Product name: NK 252
Purity: ≥98%
Packaging: 10mg
Price: $153
Updated: 2024/03/01

More

Less

N-[5-(2-Furanyl)-1,3,4-oxadiazol-2-yl]-N′-(2-pyridinylmethyl)-urea Chemical Properties,Usage,Production

Description

NK 252 is a Nrf2 activator that interacts directly with the domain containing the Nrf2-binding site of Keap1. At 1.36 μM, it is reported to activate the NQO1-antioxidant response element in a luciferase reporter gene assay two-fold above background. NK 252 has been shown to downregulate the expression of fibrogenic genes, producing antifibrotic effects in a rat model of non-alcoholic steatohepatitis.

Uses

NK 252 is a Nrf2-activator. It exhibits a greater Nrf2-activating potential than OPZ.

storage

Store at +4°C

References

[1]. shimozono r, asaoka y, yoshizawa y, et al. nrf2 activators attenuate the progression of nonalcoholic steatohepatitis-related fibrosis in a dietary rat model. mol pharmacol. 2013 jul;84(1):62-70.
[2]. kiue a, sano t, naito a, et al. reversal by two dihydropyridine compounds of resistance to multiple anticancer agents in mouse p388 leukemia in vivo and in vitro. jpn j cancer res. 1990 oct;81(10):1057-64.

N-[5-(2-Furanyl)-1,3,4-oxadiazol-2-yl]-N′-(2-pyridinylmethyl)-urea Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

N-[5-(2-Furanyl)-1,3,4-oxadiazol-2-yl]-N′-(2-pyridinylmethyl)-urea Suppliers

China 34 United Kingdom 1 United States 9 Global 44

ShangHai Caerulum Pharma Discovery Co., Ltd.

Tel: 18149758185
Email: sales-cpd@caerulumpharma.com
Country: China
ProdList: 3423
Advantage: 58

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9709
Advantage: 58

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 27322
Advantage: 60

ShangHai Biochempartner Co.,Ltd

Tel: 17754423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 8011
Advantage: 62

Shanghai Chaolan Chemical Technology Center

Tel: QQ:65489617 15618227136
Fax: 21-5161 9052
Email: info@SuperLan-chem.com
Country: China
ProdList: 9756
Advantage: 58

Twochem Co.Ltd.

Tel: 021-58111628 15800915896
Fax: QQ 3285589261
Country: China
ProdList: 1988
Advantage: 58

Shanghai Yu Ben Biotechnology Co., Ltd.

Tel: 15502154572
Fax: -
Email: yuben012@sina.com
Country: China
ProdList: 503
Advantage: 58

Angel Pharmatech, Ltd.

Tel: 17317130613
Fax: QQ3358272972
Email: 3358272972@qq.com
Country: China
ProdList: 3244
Advantage: 58

Tianjin Kaifu Pharmaceutical Technology Co., Ltd.

Tel: 18081075745
Email: chemflowtech@sina.com
Country: China
ProdList: 1886
Advantage: 58

Career Henan Chemica Co

Tel: +86-0371-86658258 15093356674;
Fax: 0371-86658258
Email: laboratory@coreychem.com
Country: China
ProdList: 30255
Advantage: 58

Shanghai Dongyang Biotechnology Co., Ltd.

Tel: 0512-0512-13601744364 13601744364
Email: chemsharker@126.com
Country: China
ProdList: 879
Advantage: 58

DC Chemicals

Tel: 021-58447131 13564518121
Email: sales@dcchemicals.com
Country: China
ProdList: 9414
Advantage: 58

Absin Bioscience Inc.

Tel: 021-38015121 15000105423
Email: chenjw@absin.cn
Country: China
ProdList: 24734
Advantage: 58

ShangHai ChuanQian Chemcial Technique Centre

Tel: 15869524721
Email: 3525679403@qq.com
Country: China
ProdList: 3689
Advantage: 58

Henan Weitesi Chemical Technology Co. LTD

Tel: 0371-0371-55135753 18003832934
Fax: QQ：2853979818
Email: 2853979818@qq.com
Country: China
ProdList: 9992
Advantage: 58

Chunchuang (Wuhan) Technology Co., Ltd

Tel: 15342225168
Email: yutianchun2007@126.com
Country: China
ProdList: 10004
Advantage: 58

Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing1@energy-chemical.com
Country: China
ProdList: 44843
Advantage: 58

MedBioPharmaceutical Technology Inc

Tel: 021-69568360 18916172912
Email: order@med-bio.cn
Country: China
ProdList: 8141
Advantage: 58

Nantong Hi-Future Biotechnology Co., Ltd

Tel: 18051384581
Email: sales@chemhifuture.com
Country: China
ProdList: 3061
Advantage: 58

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840
Email: psaitong@jm-bio.com
Country: China
ProdList: 29778
Advantage: 58

Guangzhou Yunmen Biotechnology Co., Ltd

Tel: 18902340307 18902340307
Fax: 0751-2819901
Email: 3356812514@qq.com
Country: China
ProdList: 9242
Advantage: 58

ChemeGen 中国

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
ProdList: 6975
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-1647117 15221909166
Email: product02@bidepharm.com
Country: China
ProdList: 63720
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24018
Advantage: 58

Suzhou Zhixin Biotechnology Co., Ltd.

Tel: 0512-65118909 15162312715
Email: sales@szzxbio.com
Country: China
ProdList: 2985
Advantage: 58

Beijing Solarbio Science & Tecnology Co., Ltd.

Tel: 010-50973130 17801761073
Email: Gsiyu@solarbio.com
Country: China
ProdList: 50471
Advantage: 58

Nanjing Tengyi Biotechnology Co., Ltd

Tel: 025-58851786 17714337195
Email: sales@tybiochem.com
Country: China
ProdList: 5060
Advantage: 58

https://hanhongsci.com/

Tel: 021-54306202 18917919676
Email: info@hanhongsci.com
Country: China
ProdList: 29989
Advantage: 58

Shanghai?Medlife?Pharm-Tech?Co.,?Ltd

Tel: 021-59167510 18117107507
Email: vip@med-life.cn
Country: China
ProdList: 5019
Advantage: 58

Nanjing Shizhou Biology Technology Co.,Ltd

Tel: 025-85560043 15850508050
Fax: 025-85563444
Email: cindy.huang@synzest.com
Country: China
ProdList: 12007
Advantage: 58

RD International Technology Co., Limited

Tel: 18024082417
Email: market@ubiochem.com
Country: China
ProdList: 9180
Advantage: 58

ATK CHEMICAL COMPANY LIMITED

Tel: +undefined-21-51877795
Fax: +86 21 5161 9052/ 5187 7796
Email: ivan@atkchemical.com
Country: China
ProdList: 32686
Advantage: 60

Nantong HI-FUTURE Biology Co., Ltd.

Tel: +undefined18051384581
Email: sales@chemhifuture.com
Country: China
ProdList: 3136
Advantage: 58

Shanghai Hao Zhun Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: info@zzsrm.com
Country: CHINA
ProdList: 6846
Advantage: 58

1414963-82-8, N-[5-(2-Furanyl)-1,3,4-oxadiazol-2-yl]-N′-(2-pyridinylmethyl)-ureaRelated Search:

N-[5-(2-Furanyl)-1,3,4-oxadiazol-2-yl]-N′-(2-pyridinylmethyl)-urea

NK 252;NK252

Urea, N-[5-(2-furanyl)-1,3,4-oxadiazol-2-yl]-N'-(2-pyridinylmethyl)-

NK-252 >=98% (HPLC)

NK-252,NK252,NK 252,inhibit,Inhibitor,Keap1-Nrf2

1-(5-(Furan-2-yl)-1,3,4-oxadiazol-2-yl)-3-(pyridin-2-ylmethyl)urea

1414963-82-8