ChemicalBook > CAS DataBase List > PH002

PH002

Product Name: PH002
CAS No.: 1311174-68-1
Chemical Name: PH002
Synonyms: PH002;PH 002;PH-002;PH-002 ，S0082;PH002;PH-002;PH 002;PH-002 >=98% (HPLC);PH-002, 10 mM in DMSO;ApoE4 Modulator, PH002;inhibit,PH 002,PH-002,Inhibitor,PH002;tert-butyl 4-({4-[2-(3-methyl-4-oxophthalazin-1-yl)acetamido]phenyl}methyl)piperazine-1-carboxylate - [AC77729]
CBNumber: CB72751059
Molecular Formula: C27H33N5O4
Formula Weight: 491.58
MOL File: 1311174-68-1.mol

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PH002 Property

storage temp.: Keep in dark place,Sealed in dry,2-8°C
solubility: DMSO: soluble10mg/mL (clear solution)
form: powder
color: white to beige

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0461
Product name: PH-002
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $152
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML0461
Product name: PH-002
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $605
Updated: 2025/07/31

Sigma-Aldrich

Product number: 178477
Product name: ApoE4 Modulator, PH002
Purity: A phthalazinone derived compound that directly binds to the 22-kDa amino-terminal region of apolipoprotein E4 (ApoE4) and blocks its intramolecular domain interactions in neuronal cells thereby rever
Packaging: 10 mg
Price: $269
Updated: 2025/07/31

Cayman Chemical

Product number: 27739
Product name: PH-002
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 27739
Product name: PH-002
Packaging: 25mg
Price: $533
Updated: 2024/03/01

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PH002 Chemical Properties,Usage,Production

Uses

PH-002 is an inhibitor of apolipoprotein (apo) E4 intramolecular domain interaction in neuronal cells that could rescue impairments of mitochondrial motility and neurite outgrowth.

Biological Activity

PH-002 is an inhibitor of apolipoprotein (apo) E4 intramolecular domain interaction in neuronal cells th at restores mitochondrial cytochrome c oxidase subunit 1 levels, rescues impairments of mitochondrial motility and neurite outgrowth. PH-002 is an apoE4 structure corrector th at reverses the apoE4 detrimental effects.

in vivo

PH-002 is also shown to increase COX1 levels in primary neurons from NSE-apoE4 transgenic mouse cortex and hippocampus. After 4 days of treatment with PH-002 (200 nM), COX1 levels are increased by ~60%. PH-002 (100 nM) increases dendritic spine development in primary neurons from NSE-apoE4 transgenic mice to levels comparable with those in NSE-apoE3 primary neurons (apoE3-expressing primary neurons treated with PH-002 gave results identical to untreated primary neurons)^[2].

IC 50

apoE

References

[1] Brodbeck J, et al. Structure-dependent impairment of intracellular apolipoprotein E4 trafficking and its detrimental effects are rescued by small-molecule structure correctors. J Biol Chem. 2011 May 13;286(19):17217-26. DOI:10.1074/jbc.M110.217380
[2] Chen HK, et al. Small molecule structure correctors abolish detrimental effects of apolipoprotein E4 in cultured neurons. J Biol Chem. 2012 Feb 17;287(8):5253-66. DOI:10.1074/jbc.M111.276162

PH002 Preparation Products And Raw materials

Raw materials

Preparation Products

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1311174-68-1, PH002Related Search:

4-[[4-[[2-(3,4-Dihydro-3-methyl-4-oxo-1-phthalazinyl)acetyl]amino]phenyl]methyl]-1-piperazinecarboxylic acid 1,1-dimethylethyl ester

PH 002

PH002

PH-002

PH002;PH-002;PH 002

1-Piperazinecarboxylic acid, 4-[[4-[[2-(3,4-dihydro-3-methyl-4-oxo-1-phthalazinyl)acetyl]amino]phenyl]methyl]-, 1,1-dimethylethyl ester

PH-002 >=98% (HPLC)

inhibit,PH 002,PH-002,Inhibitor,PH002

PH-002, 10 mM in DMSO

ApoE4 Modulator, PH002

PH-002 ，S0082

tert-butyl 4-({4-[2-(3-methyl-4-oxophthalazin-1-yl)acetamido]phenyl}methyl)piperazine-1-carboxylate - [AC77729]

1311174-68-1