4-AMINO-3-HYDROXY PYRIDINE

Product Name: 4-AMINO-3-HYDROXY PYRIDINE
CAS No.: 52334-53-9
Chemical Name: 4-AMINO-3-HYDROXY PYRIDINE
Synonyms: 4-AMino-3-pyridinol;4-AMINO-PYRIDIN-3-OL;3-Pyridinol, 4-amino-;Hydroxy Dalfampridine;4-Amino-pyridin-3-ol HBr;3-HYDROXY-4-AMINOPYRIDINE;4-AMINO-3-HYDROXY PYRIDINE;4-Amino-3-hydroxypyridine 97%;4-amino-3-pyridinol hydrobromide;4-Aminopyridin-3-ol hydrochloride
CBNumber: CB7286124
Molecular Formula: C5H6N2O
Formula Weight: 110.11
MOL File: 52334-53-9.mol

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4-AMINO-3-HYDROXY PYRIDINE Property

Melting point:: 222-223°C
Boiling point:: 447.4±30.0 °C(Predicted)
Density: 1.320±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
pka: 10.78±0.12(Predicted)
form: Solid
color: White to light brown
CAS DataBase Reference: 52334-53-9(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,T,Xn
Risk Statements: 36/37/38-22
Safety Statements: 26-36/37/39
Hazard Note: Irritant
HazardClass: IRRITANT, TOXIC
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: ADE000632
Product name: 4-Aminopyridin-3-ol hydrochloride
Purity: Aldrich
Packaging: 1g
Price: $817
Updated: 2025/07/31

TRC

Product number: A611605
Product name: 4-Amino-3-hydroxypyridine
Packaging: 250mg
Price: $160
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA46174
Product name: 4-Amino-3-hydroxypyridine
Packaging: 100mg
Price: $50
Updated: 2021/12/16

ChemScene

Product number: CS-W008188
Product name: 3-Hydroxy-4-aminopyridine
Packaging: 250mg
Price: $62
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA46174
Product name: 4-Amino-3-hydroxypyridine
Packaging: 250mg
Price: $82.5
Updated: 2021/12/16

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4-AMINO-3-HYDROXY PYRIDINE Chemical Properties,Usage,Production

Uses

4-Amino-3-hydroxypyridine is a hydroxylated impurity as well as a metabolite of the potassium channel blocker Fampridine (D113500).

Definition

ChEBI: 3-Hydroxy-4-aminopyridine is an aminopyridine.

Synthesis

52334-90-4

52334-53-9

Example 5 Synthesis of 4-amino-3-hydroxypyridine: 3-methoxy-4-aminopyridine (200 mg, 1.6 mmol) was dissolved in dichloromethane (15 mL) under argon protection and stirred at -70°C. Boron tribromide (10 mL, 1 M solution in dichloromethane, 6 eq.) was added slowly over 10 min. After stirring under cooling conditions for 15 minutes, the reaction mixture was gradually warmed to room temperature and continued to stir overnight. After completion of the reaction, the solvent was removed by distillation under reduced pressure. The residue was mixed with methanol and saturated sodium bicarbonate solution and stirred for 25 minutes. The mixture was filtered and the filtrate was evaporated. The residue was stirred with a solvent mixture of dichloromethane/methanol/ammonia (75/25/2, v/v/v), filtered, and purified by silica gel column chromatography using the same solvent mixture as eluent to give 145 mg (81% yield) of the target product 4-amino-3-hydroxypyridine with a melting point of 205°C (literature value: 188°-191°C). The structure of the product was confirmed by proton NMR spectroscopy. Elemental analysis results: Calculated values (C5H6N2O-0.2H2O): C, 52.81; H, 5.67; N, 24.63. Measured values: C, 53.02; H, 5.63; N, 24.40.

References

[1] Patent: US5652363, 1997, A

4-AMINO-3-HYDROXY PYRIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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4-AMINO-3-HYDROXY PYRIDINE Suppliers

Canada 1 China 120 Germany 3 India 8 United Kingdom 6 United States 20 Global 158

J & K SCIENTIFIC LTD.

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View Lastest Price from 4-AMINO-3-HYDROXY PYRIDINE manufacturers

Dideu Industries Group Limited

Product: 4-AMINO-3-HYDROXY PYRIDINE 52334-53-9
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons Min
Release date: 2021-09-24

Career Henan Chemical Co

Product: 4-AMINO-3-HYDROXY PYRIDINE 52334-53-9
Price: US $1.00/g
Min. Order: 1g
Purity: 98%
Supply Ability: 100KG
Release date: 2020-01-12

52334-53-9, 4-AMINO-3-HYDROXY PYRIDINERelated Search:

N-(2-CHLORO-3-HYDROXYPYRIDIN-4-YL)PIVALAMIDE 3-HYDROXY-4-NITROPYRIDINE 5-Amino-2-hydroxypyridine 4-AMINO-PYRIDIN-2-OL 4-AMINO-3-HYDROXY PYRIDINE N-(3-HYDROXY-PYRIDIN-4-YL)-2,2-DIMETHYL-PROPIONAMIDE 5-Amino-2-pyridinol 1-oxide 2-Amino-3-hydroxypyridine 3-Amino-2(1H)-pyridinone SALOR-INT L211184-1EA 4-Amino-3-methoxypyridine 4-Amino-3-methoxy-5-nitropyridine 2-CHLORO-3-HYDROXY-4-NITRO-6-METHYLPYRIDINE 4-phenoxypyridin-3-amine 1H-PYRIDO[3,4-B][1,4]OXAZIN-2(3H)-ONE, 7-CHLORO- 1-(3-([3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]OXY)-2-METHYL-4-PYRIDINYL)-4-METHYLPIPERAZINE 4-AMINO-3,5-DIMETHOXYPYRIDINE 3-ETHOXY-4-NITROPYRIDINE

4-AMINO-PYRIDIN-3-OL

4-AMINO-3-HYDROXY PYRIDINE

4-AMINO-3-HYDROXYPYRIDINE HYDROCHLORIDE

4-Amino-3-pyridinol hydrochloride

3-HYDROXY-4-AMINOPYRIDINE

4-Amino-pyridin-3-ol HBr

4-Aminopyridin-3-ol hydrochloride

3-Pyridinol, 4-amino-

4-Aminopyridin-3-ol hydrochloride, 3-Hydroxypyridin-4-amine hydrochloride

4-AMino-3-pyridinol

4-amino-3-pyridinol hydrobromide

4-Amino-3-hydroxypyridine 97%

Fampridine Impurity 5（4-Amino-3-Hydroxy-Pyridine）

4-AMINO-3-HYDROXY PYRIDINE ISO 9001：2015 REACH

3-Hydroxy-4-aminopyridine HydrochlorideQ: What is 3-Hydroxy-4-aminopyridine Hydrochloride Q: What is the CAS Number of 3-Hydroxy-4-aminopyridine Hydrochloride Q: What is the storage condition of 3-Hydroxy-4-aminopyridine Hydrochloride Q: What are the applications of 3-Hydroxy-4-aminopyridine Hydrochloride

Hydroxy Dalfampridine

52334-53-9

52334-43-9

Pyridines, Pyrimidines, Purines and Pteredines

pharmacetical

Pyridine series

Amines

Pyridines

Pyridine

Building Blocks

Aromatics

Heterocycles

Metabolites & Impurities