(R)-5-Amino-1-(1-cyanopiperidin-3-yl)-3-(4-[2,4-difluorophenoxy]phenyl)-1H-pyrazole-4-carboxamide

Product Name: (R)-5-Amino-1-(1-cyanopiperidin-3-yl)-3-(4-[2,4-difluorophenoxy]phenyl)-1H-pyrazole-4-carboxamide
CAS No.: 1609465-89-5
Chemical Name: (R)-5-Amino-1-(1-cyanopiperidin-3-yl)-3-(4-[2,4-difluorophenoxy]phenyl)-1H-pyrazole-4-carboxamide
Synonyms: PF-06250112;PF06250112,PF 06250112;(R)-5-Amino-1-(1-cyanopiperidin-3-yl)-3-(4-[2,4-difluorophenoxy]phenyl)-1H-pyrazole-4-carboxamide;1H-Pyrazole-4-carboxamide, 5-amino-1-[(3S)-1-cyano-3-piperidinyl]-3-[4-(2,4-difluorophenoxy)phenyl]-
CBNumber: CB72891555
Molecular Formula: C22H20F2N6O2
Formula Weight: 438.43
MOL File: 1609465-89-5.mol

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(R)-5-Amino-1-(1-cyanopiperidin-3-yl)-3-(4-[2,4-difluorophenoxy]phenyl)-1H-pyrazole-4-carboxamide Property

Boiling point:: 643.6±55.0 °C(Predicted)
Density: 1.46±0.1 g/cm3(Predicted)
storage temp.: -20°C
solubility: Soluble in DMSO
form: powder
pka: 14.99±0.50(Predicted)
color: white to beige

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26

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Hazard and Precautionary Statements (GHS)

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(R)-5-Amino-1-(1-cyanopiperidin-3-yl)-3-(4-[2,4-difluorophenoxy]phenyl)-1H-pyrazole-4-carboxamide Chemical Properties,Usage,Production

Biological Activity

PF-06250112 is a potent inhibitor of Brutonμs tyrosine kinase (BTK). PF-06250112 blocks both B-cell receptor and FcR-mediated signaling, and prevents FcR-dependent, Antibody-mediated proteinuria in a mouse glomerulonephritis model.

(R)-5-Amino-1-(1-cyanopiperidin-3-yl)-3-(4-[2,4-difluorophenoxy]phenyl)-1H-pyrazole-4-carboxamide Preparation Products And Raw materials

Raw materials

Preparation Products

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(R)-5-Amino-1-(1-cyanopiperidin-3-yl)-3-(4-[2,4-difluorophenoxy]phenyl)-1H-pyrazole-4-carboxamide Suppliers

China 2 United States 5 Global 7

Sichuan Wei Keqi Biological Technology Co., Ltd.

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TargetMol Chemicals Inc.

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TargetMol Chemicals Inc.

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TargetMol Chemicals Inc.

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TargetMol Chemicals Inc.

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1609465-89-5, (R)-5-Amino-1-(1-cyanopiperidin-3-yl)-3-(4-[2,4-difluorophenoxy]phenyl)-1H-pyrazole-4-carboxamideRelated Search:

(R)-5-Amino-1-(1-cyanopiperidin-3-yl)-3-(4-[2,4-difluorophenoxy]phenyl)-1H-pyrazole-4-carboxamide

PF-06250112

1H-Pyrazole-4-carboxamide, 5-amino-1-[(3S)-1-cyano-3-piperidinyl]-3-[4-(2,4-difluorophenoxy)phenyl]-

PF06250112,PF 06250112

1609465-89-5