Pharmacological effects Indications
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Fenspiride hydrochloride

Pharmacological effects Indications
Product Name
Fenspiride hydrochloride
CAS No.
5053-08-7
Chemical Name
Fenspiride hydrochloride
Synonyms
jp428;Erespal;NAT 333;espiran;fluiden;Tegencia;Decaspir;pneumorel;Viarespan;NDR 5998A
CBNumber
CB7295887
Molecular Formula
C15H21ClN2O2
Formula Weight
296.8
MOL File
5053-08-7.mol
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Fenspiride hydrochloride Property

Melting point:
235-238°C (dec.)
storage temp. 
Refrigerator
solubility 
DMSO (Slightly), Methanol (Slightly), Water (Slightly)
form 
powder
color 
white
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Safety

Hazard Codes 
Xn
Risk Statements 
20/21/22
Safety Statements 
36
WGK Germany 
3
RTECS 
RO0375000
HS Code 
2934.99.3000
Toxicity
LD50 i.v. in mice: 106 mg/kg; orally in rats: 437 mg/kg (LeDouarec)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H332Harmful if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P322Specific measures (see …on this label).

P330Rinse mouth.

P363Wash contaminated clothing before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical
Product number
F1211
Product name
Fenspiride Hydrochloride
Packaging
1G
Price
$61
Updated
2024/03/01
TCI Chemical
Product number
F1211
Product name
Fenspiride Hydrochloride
Packaging
5G
Price
$171
Updated
2024/03/01
Cayman Chemical
Product number
25512
Product name
Fenspiride (hydrochloride)
Purity
≥95%
Packaging
5g
Price
$56
Updated
2024/03/01
Cayman Chemical
Product number
25512
Product name
Fenspiride (hydrochloride)
Purity
≥95%
Packaging
10g
Price
$97
Updated
2024/03/01
Cayman Chemical
Product number
25512
Product name
Fenspiride (hydrochloride)
Purity
≥95%
Packaging
25g
Price
$216
Updated
2024/03/01
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Fenspiride hydrochloride Chemical Properties,Usage,Production

Pharmacological effects

As an α adrenergic and H1 histamine receptor antagonist, Fenspiride has been shown to be antiinflammatory, anti-allergic and antioxidant. Fenspiride inhibited SO2-induced goblet cell hyperplasia in rats, with concomitant inhibition of increased hexose and fucose, indicative of mucus hypersecretion, in lavage fluid. Fenspiride also exhibits neuronal inhibitory activity. For example, in guinea pigs, it reverses capsaicin-induced and citric acid-induced bronchoconstriction and cough, and inhibits cholinergic and non-adrenergic, non-cholinergic (NANC) neural contraction of isolated bronchi.

Indications

Fenspiride hydrochloride is a bronchodilator, which was used as a drug in the treatment of certain respiratory diseases. Finsecbili hydrochloride against serotonin, dilating bronchial smooth muscle, the intensity of action is between isoproterenol and theophylline, in addition to reducing the resistance of air movement in the lungs, experiments have shown that this product has dilated bronchial smooth muscle, antitussive, antipyretic and analgesic effects. Suitable for chronic bronchitis, bronchial asthma and chronic respiratory insufficiency.  In Russia it was approved for the treatment of acute and chronic inflammatory diseases of ENT organs and the respiratory tract, as well as for maintenance treatment of asthma (like rhinopharyngitis, laryngitis, tracheobronchitis, otitis and sinusitis).

Chemical Properties

Pale Yellow Solid

Originator

Viarespan,Servier,France,1969

Uses

Antiinflammatory;Bradykinin antagonist

Uses

Bronchodilator with anti-inflammatory properties. Inhibits mucus secretion and reduces the release of tachykinins at a prejunctional level by its anti-muscarinic action. It also may be an antagonist at α adrenergic and H1 histamine receptors.

Manufacturing Process

A solution of 192 g of 1-phenethyl-4-hydroxy-4-aminomethyl piperidine in 800 cc of diethylcarbonate is heated for 2? hours to reflux at about 80°C in the presence of sodium methylate (prepared for immediate use from 2 g of sodium). After this time, the ethyl alcohol formed during the reaction is slowly distilled while the maximum temperature is reached. The excess ethyl carbonate is distilled under reduced pressure. A crystallized residue is then obtained, which is stirred with 400 cc of water and 400 cc of ether. The solution is filtered and 125 g (77.6%) of practically pure product melting at 232°C to 233°C, are obtained.
The starting material was prepared in a yield of 58% by reduction of the corresponding cyanohydrin. It in turn was prepared from 1-(2-phenylethyl)-4- piperidone and potassium cyanide to give the cyanohydrin which was reduced by lithium aluminum hydride.

Therapeutic Function

Bronchodilator

Fenspiride hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Fenspiride hydrochloride Suppliers

J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
Tianjin heowns Biochemical Technology Co., Ltd.
Tel
400 638 7771
Email
sales@heowns.com
Country
China
ProdList
14435
Advantage
57
Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
sales@meilune.com
Country
China
ProdList
4727
Advantage
58
Tianjin Branch Chong pharmaceutical intermediates Co., Ltd.
Tel
022-60116533 13207668525
Fax
022-60979672
Email
saleskc@scipharmacn.com
Country
China
ProdList
683
Advantage
58
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7552
Advantage
61
TOKYO CHEMICAL INDUSTRY CO., LTD.
Tel
03-36680489
Fax
03-3668-0520
Email
Sales-JP@TCIchemicals.com
Country
Japan
ProdList
28387
Advantage
80
TCI Europe
Tel
320-37350700
Fax
+32 (0)37350701
Email
sales@tcieurope.eu
Country
Europe
ProdList
23671
Advantage
75
TCI AMERICA
Tel
800-4238616
Fax
+1-888-520-1075 / +1-503-283-1987
Email
sales@tciamerica.com
Country
Americas
ProdList
23653
Advantage
75
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4861
Advantage
58
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View Lastest Price from Fenspiride hydrochloride manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
Fenspiride Hydrochloride
Price
US $0.01-1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50 tons
Release date
2020-04-24
Shanghai CRM New Material Technology Co., LTD
Product
fenspiride hydrochloride 5053-08-7
Price
US $10.00-15.00/g
Min. Order
10g
Purity
99%
Supply Ability
2546245
Release date
2022-11-04
Hebei Binshare New Material Co. Ltd
Product
Fenspiride hydrochloride 5053-08-7
Price
US $1.00/g
Min. Order
1g
Purity
99%
Supply Ability
10tons
Release date
2020-09-03

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