2'-O-Propygylguanosine
- Product Name
- 2'-O-Propygylguanosine
- CAS No.
- 206552-86-5
- Chemical Name
- 2'-O-Propygylguanosine
- Synonyms
- 2'-O-propargyl-rG;2'-O-Propygylguanosine;2’-O-Propygylguanosine;2’-O-Propargylguanosine;2’-O-(2-Propyn-1-yl)guanosine;Guanosine, 2'-O-2-propyn-1-yl-
- CBNumber
- CB73035240
- Molecular Formula
- C13H15N5O5
- Formula Weight
- 321.29
- MOL File
- 206552-86-5.mol
2'-O-Propygylguanosine Property
- Density
- 1.76±0.1 g/cm3(Predicted)
- pka
- 9?+-.0.20(Predicted)
- InChI
- InChI=1S/C13H15N5O5/c1-2-3-22-9-8(20)6(4-19)23-12(9)18-5-15-7-10(18)16-13(14)17-11(7)21/h1,5-6,8-9,12,19-20H,3-4H2,(H3,14,16,17,21)/t6-,8-,9-,12-/m1/s1
- InChIKey
- VBIXIAQUDWOPDT-WOUKDFQISA-N
- SMILES
- OC[C@H]1O[C@@H](N2C3=C(C(NC(=N3)N)=O)N=C2)[C@H](OCC#C)[C@@H]1O
N-Bromosuccinimide Price
- Product number
- NP06253
- Product name
- 2'-O-Propargylguanosine
- Packaging
- 5mg
- Price
- $68.3
- Updated
- 2021/12/16
- Product number
- NP06253
- Product name
- 2'-O-Propargylguanosine
- Packaging
- 10mg
- Price
- $115.5
- Updated
- 2021/12/16
- Product number
- 1455EM
- Product name
- 2-Amino-9-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-prop-2-ynoxyoxolan-2-yl]-1H-purin-6-one
- Packaging
- 10mg
- Price
- $205
- Updated
- 2021/12/16
- Product number
- NP06253
- Product name
- 2'-O-Propargylguanosine
- Packaging
- 25mg
- Price
- $236.5
- Updated
- 2021/12/16
- Product number
- 1455EM
- Product name
- 2-Amino-9-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-prop-2-ynoxyoxolan-2-yl]-1H-purin-6-one
- Packaging
- 25mg
- Price
- $369
- Updated
- 2021/12/16
2'-O-Propygylguanosine Chemical Properties,Usage,Production
Description
2′-O-2-Propyn-1-ylguanosine (2'-O-Propygylguanosine) is a guanosine analogue. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7). 2′-O-2-Propyn-1-ylguanosine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Uses
2′-O-2-Propyn-1-ylguanosine is a guanosine analogue. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7)[1]. 2′-O-2-Propyn-1-ylguanosine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Solubility in organics
10 mM in DMSO
References
[1] Lee J, et al. Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: activation of Toll-like receptor 7. Proc Natl Acad Sci U S A. 2003 May 27;100(11):6646-51. DOI:10.1073/pnas.0631696100
2'-O-Propygylguanosine Preparation Products And Raw materials
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