ChemicalBook > CAS DataBase List > Pyr10

Pyr10

Product Name: Pyr10
CAS No.: 1315323-00-2
Chemical Name: Pyr10
Synonyms: Pyr10;PYR-10;PYR 10;Pyr10 >=98% (HPLC);Pyr10, 10 mM in DMSO;TRPC3 Channel Inhibitor III, Pyr10;N-{4-[3,5-Bis(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}-4-methylbenzenesulfonamide;Benzenesulfonamide, N-[4-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]-4-methyl-;l-NAME,pyrazole,SOCE,Inhibitor,TRPC3,fibroblast,cardiac,ROCE,inhibit,Orai,STIM1,Pyr 10,Transient receptor potential channels,Ca2+,TRP Channel,Pyr10,Pyr-10
CBNumber: CB73040228
Molecular Formula: C18H13F6N3O2S
Formula Weight: 449.37
MOL File: 1315323-00-2.mol

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Pyr10 Property

Melting point:: 105-107 °C
Boiling point:: 470.1±55.0 °C(Predicted)
Density: 1.47±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : 100 mg/mL (222.53 mM);Water : < 0.1 mg/mL (insoluble)
form: Solid
pka: 6.98±0.10(Predicted)
color: White to light yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1243
Product name: Pyr10
Purity: ≥98% (HPLC)
Packaging: 5 mg
Price: $121
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML1243
Product name: Pyr10
Purity: ≥98% (HPLC)
Packaging: 25 mg
Price: $324
Updated: 2025/07/31

Sigma-Aldrich

Product number: 648494
Product name: TRPC3 Channel Inhibitor III, Pyr10
Packaging: 10 mg
Price: $209
Updated: 2025/07/31

Tocris

Product number: 6941
Product name: Pyr10
Purity: ≥98%(HPLC)
Packaging: 50
Price: $545
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb611723
Product name: Pyr10
Packaging: 50mg
Price: $584.8
Updated: 2021/12/16

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Pyr10 Chemical Properties,Usage,Production

Uses

Pyr10 is a pyrazole derivative and a selective TRP cation 3 (TRPC3) inhibitor. Pyr10 inhibits Ca2+ influx in carbachol-stimulated TRPC3-transfected HEK293 cells with an IC50 of 0.72 μM (IC50 of 13.08 μM for store operated Ca2+ entry in BRL-2H3 cells). Pyr10 has the ability to distinguish between receptor-operated TRPC3 and native stromal interaction molecule 1 (STIM1)/Orai1 channels[1].

Biological Activity

Pyr10 is a novel, selective inhibitor of the transient receptor potential channel TRPC3. Pyr10 blocks carbachol-induced calcium entry into TRPC3-transfected HEK293 cells (IC50 = 0.72 μM), with significantly lower activity against STIM1/Orai1 mediated release of calcium from endoplasmic reticulum (store operated calcium entry) in BRL-2H3 cells (IC50 = 13.08 μM).

in vivo

Genetic deletion (TRPC3^-/-) and pharmacological channel blockade with Pyr10 blunts ventricular cardiac fibroblast activation and myocardial fibrosis in N(ω)-nitro-l-arginine methyl ester (l-NAME) hypertensive mice^[2].

IC 50

TRPC3: 0.72 μM (IC₅₀)

storage

Store at -20°C

References

[1] Schleifer H, et al. Novel pyrazole compounds for pharmacological discrimination between receptor-operated and store-operated Ca(2+) entry pathways. Br J Pharmacol. 2012 Dec;167(8):1712-1722. DOI:10.1111/j.1476-5381.2012.02126.x
[2] Saliba Y, et al. Transient Receptor Potential Canonical 3 and Nuclear Factor of Activated T Cells C3 Signaling Pathway Critically Regulates Myocardial Fibrosis. Antioxid Redox Signal. 2019 Jun 1;30(16):1851-1879. DOI:10.1089/ars.2018.7545

Pyr10 Preparation Products And Raw materials

Raw materials

Preparation Products

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1315323-00-2, Pyr10Related Search:

Pyr10

N-{4-[3,5-Bis(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}-4-methylbenzenesulfonamide

PYR-10;PYR 10

Benzenesulfonamide, N-[4-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]-4-methyl-

Pyr10 >=98% (HPLC)

l-NAME,pyrazole,SOCE,Inhibitor,TRPC3,fibroblast,cardiac,ROCE,inhibit,Orai,STIM1,Pyr 10,Transient receptor potential channels,Ca2+,TRP Channel,Pyr10,Pyr-10

Pyr10, 10 mM in DMSO

TRPC3 Channel Inhibitor III, Pyr10

1315323-00-2