ChemicalBook > CAS DataBase List > A-1210477

A-1210477

Product Name
A-1210477
CAS No.
1668553-26-1
Chemical Name
A-1210477
Synonyms
CS-2151;CS-2202;A-1210477;A-1210477 ，S7790;A-1210477 (A1210477);Abbvie Mcl-1 Inhibitor;A-1210477;A 1210477;A1210477;A-1210477,inhibit,Inhibitor,A 1210477,Bcl-2 Family,A1210477,Apoptosis;7-(5-((4-(4-(N,N-dimethylsulfamoyl)piperazin-1-yl)phenoxy)methyl)-1,3-dimethyl-1H-pyrazol-4-yl)-1-(2-morpholinoethyl)-3-(3-(naphthalen-1-yloxy)propyl)-1H-indole-2-carboxylic acid;7-[5-[[4-[4-[(Dimethylamino)sulfonyl]-1-piperazinyl]phenoxy]methyl]-1,3-dimethyl-1H-pyrazol-4-yl]-1-[2-(4-morpholinyl)ethyl]-3-[3-(1-naphthalenyloxy)propyl]-1H-indole-2-carboxylic acid
CBNumber
CB73040415
Molecular Formula
C46H55N7O7S
Formula Weight
850.04
MOL File
1668553-26-1.mol
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A-1210477 Property

Boiling point:
1027.4±65.0 °C(Predicted)
Density 
1.32±0.1 g/cm3(Predicted)
storage temp. 
Sealed in dry,Store in freezer, under -20°C
solubility 
insoluble in DMSO; insoluble in H2O; insoluble in EtOH
form 
Powder
pka
4.43±0.30(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H400Very toxic to aquatic life

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P273Avoid release to the environment.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P391Collect spillage. Hazardous to the aquatic environment

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML1932
Product name
A-1210477
Purity
≥98% (HPLC)
Packaging
5 mg
Price
$108
Updated
2025/07/31
Sigma-Aldrich
Product number
SML1932
Product name
A-1210477
Purity
≥98% (HPLC)
Packaging
25 mg
Price
$436
Updated
2025/07/31
Cayman Chemical
Product number
21113
Product name
A-1210477
Purity
≥98%
Packaging
1mg
Price
$38
Updated
2024/03/01
Cayman Chemical
Product number
21113
Product name
A-1210477
Purity
≥98%
Packaging
5mg
Price
$166
Updated
2024/03/01
Cayman Chemical
Product number
21113
Product name
A-1210477
Purity
≥98%
Packaging
10mg
Price
$292
Updated
2024/03/01
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A-1210477 Chemical Properties,Usage,Production

Description

A-1210477 is an inhibitor of the antiapoptotic Bcl-2 family protein myeloid cell leukemia-1 (Mcl-1; Ki = 0.43 nM and IC50 = 26.2 nM) that demonstrates >100-fold selectivity over other Bcl-2 family members (Kis > 0.66 μM for Bcl-2, Bcl-XL, Bcl-W, and Bfl-1). It has been shown to disrupt the interaction between Mcl-1 and pro-apoptotic BIM, inducing the hallmarks of apoptosis in Mcl-1-dependent multiple myeloma and non-small cell lung cancer cell lines.

Uses

Abbvie Mcl-1 Inhibitor is an inhibitor of Mcl-1 where Mcl-1 is an anti-apoptotic.

IC 50

Mcl-1: 0.45 nM (Ki); Bcl-2: 132 nM (Ki); Bfl-1: 660 nM (Ki); Bcl-W: 2280 nM (Ki); Apoptosis

References

[1]. lopez j, bessou m, riley js, et al. mito-priming as a method to engineer bcl-2 addiction. nature communications, 2016, 7:10538.
[2]. besbes s, mirshahi m, pocard m, et al. new dimension in therapeutic targeting of bcl-2 family proteins. oncotarget, 2015, 6(15): 12862.
[3]. leverson jd, zhang h, chen j, et al. potent and selective small-molecule mcl-1 inhibitors demonstrate on-target cancer cell killing activity as single agents and in combination with abt-263 (navitoclax). cell death & disease, 2015, 6(1): e1590.
[4]. mott jl, kobayashi s, bronk sf, et al. mir-29 regulates mcl-1 protein expression and apoptosis. oncogene, 2007, 26(42): 6133-6140.
[5]. opferman jt. attacking cancer's achilles heel: antagonism of anti-apoptotic bcl-2 family members. febs journal, 2015.

A-1210477 Preparation Products And Raw materials

Raw materials

Preparation Products

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A-1210477 Suppliers

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1668553-26-1, A-1210477Related Search:


  • A-1210477
  • 7-(5-((4-(4-(N,N-dimethylsulfamoyl)piperazin-1-yl)phenoxy)methyl)-1,3-dimethyl-1H-pyrazol-4-yl)-1-(2-morpholinoethyl)-3-(3-(naphthalen-1-yloxy)propyl)-1H-indole-2-carboxylic acid
  • Abbvie Mcl-1 Inhibitor
  • 7-[5-[[4-[4-[(Dimethylamino)sulfonyl]-1-piperazinyl]phenoxy]methyl]-1,3-dimethyl-1H-pyrazol-4-yl]-1-[2-(4-morpholinyl)ethyl]-3-[3-(1-naphthalenyloxy)propyl]-1H-indole-2-carboxylic acid
  • CS-2202
  • CS-2151
  • A-1210477;A 1210477;A1210477
  • 1H-Indole-2-carboxylic acid, 7-[5-[[4-[4-[(dimethylamino)sulfonyl]-1-piperazinyl]phenoxy]methyl]-1,3-dimethyl-1H-pyrazol-4-yl]-1-[2-(4-morpholinyl)ethyl]-3-[3-(1-naphthalenyloxy)propyl]-
  • A-1210477,inhibit,Inhibitor,A 1210477,Bcl-2 Family,A1210477,Apoptosis
  • A-1210477 (A1210477)
  • A-1210477 ，S7790
  • 1668553-26-1
  • C46H55N7O7S
  • Inhibitors